Characterizing Signals Within Lesions and Mapping Brain Network Connectivity After Traumatic Axonal Injury: A 7 Tesla Resting-State FMRI Study

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Description: Resting-state functional magnetic resonance imaging (RS-FMRI) has been widely used to map brain functional connectivity, but it is unclear how to probe connectivity within and around lesions. In this study, we characterize RS-FMRI signal time course properties and evaluate different seed placements within and around hemorrhagic traumatic axonal injury (hTAI) lesions. RS-FMRI was performed on a 7 Tesla scanner in a patient who recovered consciousness after traumatic coma and in three healthy controls. Eleven lesions in the patient were characterized in terms of temporal signal-to-noise ratio (tSNR), physiological noise and seed-based functional connectivity. We showed that resting-state network has been changed in the brain after recovery from traumatic coma and that seed placement within a lesion’s periphery or in the contralesional hemisphere may be necessary for network identification in patients with hTAI.

Lee Seul, Polimeni Jonathan R., Price Collin M., Edlow Brian L., and McNab Jennifer A..Characterizing Signals Within Lesions and Mapping Brain Network Connectivity After Traumatic Axonal Injury: A 7 Tesla Resting-State FMRI Study. Brain Connectivity.Jun 2018.DOI: 10.1089/brain.2017.0499

link: https://doi.org/10.1089/brain.2017.0499