Imaging of cerebrovascular reserve and oxygenation in Moyamoya disease

Imaging of cerebrovascular reserve and oxygenation in Moyamoya disease

Cerebrovascular perfusion reserve, measured with a physiologic challenge such as the injection of acetazolamide, is a valuable tool in informing clinical decision-making in cerebrovascular diseases such as Moyamoya disease. In this study, we explore the use of spin relaxation rates including R2’, which provides tissue oxygenation information, in evaluating brain tissue function in Moyamoya disease. We found that, unlike baseline perfusion, baseline R2’ measurements can distinguish between angiographically normal and abnormal regions. This is a promising result for further development of oxygenation measurement in cerebrovascular diseases.

 

 

Ni WW, Christen T, Rosenberg J, Zun Z, Moseley ME, Zaharchuk G. Imaging of cerebrovascular reserve and oxygenation in Moyamoya disease. J. Cereb. Blood Flow Metab. 2016: in press.