Research Management Group (RMG)

2013-2014 Spectrum Innovation Accelerator Seed Grants Program
Request for Proposals

Spectrum, the Stanford Center for Clinical and Translational Research and Education, is a Stanford independent center supported, in part, by a National Institutes of Health Clinical and Translational Science Award (CTSA), under the direction of the National Center for Advancing Translational Sciences (NCATS). For more information on Spectrum, please visit: spectrum.stanford.edu

Download the RFP (updated 09/05/13) >>  PDF file

Introduction
The Stanford CTSA/Spectrum Innovation Accelerator Seed Grant Program has two major goals: to stimulate innovative clinical and translational research and to encourage collaborative, transdisciplinary work within each of the aforementioned areas. The primary expectation is that these early-stage translational projects will lead to additional research, external support, information dissemination and most importantly, will develop into longer term, comprehensive projects. While we encourage transdisciplinary collaborations, it is not a requirement for funding. Please refer to Page 5 of the program guidelines for detailed policies and procedures.  

Award Process:
Proposals will be reviewed by independent faculty review committees within each of the four themes and will be based on individual selection criteria and scoring systems. In general, reviewers will support applications that have made convincing arguments that the investigator(s) is proposing a bold idea or approach that can have a major translational impact in biomedical or behavioral research or is building a community partnership that can lead to a sustained collaboration for community-based research. We expect to invite finalists for oral presentations before December 2013 and to notify awardees by January 2014
.

 

 

#1- Spectrum Innovation Accelerator Seed Grants in Medtech (Biodesign), Therapeutics (SPARK) and Diagnostics


Therapeutics (SPARK) deadline: Friday, Oct. 18, 2013:
Medtech (Biodesign) deadline: Wed., Oct. 30, 2013:
Diagnostics and Predictive Medicine deadline: Wed., Oct. 30, 2013:
See proposal submission guidelines below >>

Amount and Period of Funding
Typical grants vary between $15,000-50,000/year and depend on the specific program and the individual proposal. See each section below for amounts of grants by theme. Awards will be granted for the period from January 1, 2014 through December 31, 2014 and MUST be completed in that timeframe.  All unexpended funds will be returned to the CTSA after the 12-month award period.

Eligibility (for all categories): 
Open to all Stanford faculty with PI-eligibility (with UTL, MCL and NTL-Research appointments). Graduate students, clinical and non-clinical postdoctoral fellows are encouraged to apply with the leadership of a Stanford-affiliated faculty mentor.

Program
The Stanford CTSA/Spectrum Innovation Accelerator Seed Grant Program has two major goals: to stimulate innovative clinical and translational research and to encourage collaborative, transdisciplinary work within each of the aforementioned areas. The primary expectation is that these early-stage translational projects will lead to additional research, external support, information dissemination and most importantly, will develop into longer term, comprehensive projects. While we encourage transdisciplinary collaborations, it is not a requirement for funding. Please refer to Page 5 of the program guidelines for detailed policies and procedures.

Proposed projects within the thematic areas of Medtech (Biodesign), Therapeutics (SPARK) or Diagnostics must have the objective of translating discoveries into novel medtech, biopharma, or diagnostic products that address unmet medical needs.  Emphasis will be placed on technologies that have the potential to advance rapidly into clinical care through commercialization or other pathways. Funds must be applied to specific tasks that advance the technology toward the clinic. Some examples include prototype device development, performance of high throughput screens for bioactive compounds, preclinical safety testing, and investigator-initiated pilot clinical studies.

Thematic Areas

    • The defined scope of the Medtech (Biodesign) component is to support projects that apply a systematic approach to clinical needs finding and the invention and implementation of novel biomedical technologies into patient care.  Some illustrative examples of past Medtech Accelerator seed grant support include: a $800 12V portable ventilator, and a novel catheter treatment for deep venous insufficiency.
    • The defined scope of the Therapeutics (SPARK) component is to support projects that apply innovative, cost-effective means toward translating academic discoveries into drugs and therapeutics that address a clinical need. Some illustrative examples of the Therapeutics Accelerator seed grant support include: a repurposed Drug for Basal Cell Carcinoma and a novel GABA-antagonist for Down Syndrome.
    • The defined scope of the new Diagnostics and Predictive Medicine component is on projects with a goal of predicting the onset, course, worsening, or complications of disease, and prolonging health. Some potential examples under the Diagnostics Accelerator include: the development of mobile apps to promote healthy behavior, the development of serum tests to screen for cancer, the combination and development of genetic sequencing and computational tools to diagnose rare diseases.


Proposal Requirements/Submission:

Please submit your application materials electronically as A SINGLE PDF file to the respective program managers:

Friday, Oct. 18, 2013: Therapeutics (SPARK): Kanad Das, Ph.D.  kanaddas@stanford.edu
Wed., Oct. 30, 2013: Medtech (Biodesign): Gordon Saul, MBA gsaul@stanford.edu and
Wed., Oct. 30, 2013: Diagnostics and Predictive Medicine: Anandi Krishnan, Ph.D., anandi.krishnan@stanford.edu
Please contact the individual program managers for any questions on scope, criteria or the review process.

All Medtech, Therapeutics or Diagnostics seed grant proposals must include the following sections:

    • Title Page (Spectrum Innovation Accelerator Seed Grant Program)
      • Title of Proposal
      • Type of Proposal (Medtech, Biopharma, Diagnostic)
      • PI Name, Title, Department, Contact
      • Mentor Name, Title, Department, Contact*
        * for Graduate Students and Postdoctoral Fellows
    • Research Plan/Description of Proposed Product or Platform
      Limit the total of the subsections (a-f) to 3 pages including any figures or tables; and excluding references
      • a. Description of Underlying Technology
      • b. Clinical Indication/Need and Brief Scope of Market
      • c. Comparison to Current Standard of Care (in effectiveness and cost)
      • d. Translational Objectives (what will be achieved with this funding)
      • e. Preliminary Data (if any)
      • f. Development Plan
    • Detailed Budget, Budget Justification and Contact for Dept/Divisional Financial Manager (1/2-1pg)
    • NIH Biosketches (4 page version) for PI and Co-Investigators

 

 


#2- Spectrum Innovation Accelerator Seed Grants in Population Health Sciences, including Community Engagement


Proposal Deadline: Wed., Oct. 30, 2013

See proposal submission guidelines below >>

Amount and Period of Funding

Typical grants vary between $15,000-50,000/year and depend on the specific program and the individual proposal. See each section below for amounts of grants by theme. Awards will be granted for the period from January 1, 2014 through December 31, 2014 and MUST be completed in that timeframe.  All unexpended funds will be returned to the CTSA after the 12-month award period.

Eligibility (for all categories): 
Open to all Stanford faculty with PI-eligibility (with UTL, MCL and NTL-Research appointments). Stanford Graduate students, clinical and non-clinical postdoctoral fellows are encouraged to apply with the leadership of a Stanford-affiliated faculty mentor. Clinician Educators are eligible through the CE Faculty PI waiver process >>.

Program
The Stanford CTSA/Spectrum Innovation Accelerator Seed Grant Program has two major goals: to stimulate innovative clinical and translational research and to encourage collaborative, transdisciplinary work within each of the aforementioned areas. The primary expectation is that these early-stage translational projects will lead to additional research, external support, information dissemination and most importantly, will develop into longer term, comprehensive projects. While we encourage transdisciplinary collaborations, it is not a requirement for funding. Please refer to Page 5 of the program guidelines for detailed policies and procedures.  

Thematic Areas

    • Proposed projects within Population Health Sciences, including Community Engagement, must have a clear focus on the health of populations. The Stanford Population Health Science Initiative aims to facilitate information exchange, collaboration and resource sharing among faculty, staff, students and community partners interested in population health. Organizers are also working to build interdisciplinary teams of biomedical researchers, information scientists, physicians, engineers, social scientists, regional healthcare experts and others to design and implement the learning health care systems of the future. These systems will draw on the day-to-day experiences of practicing doctors, as well as information extracted from clinical data warehouses as well as a variety of diagnostic assays and measurements to create new sources of practice-based evidence. Funds must be applied to specific tasks that address these goals. Some examples include research on health care delivery; physical and social environments; comparative effectiveness, health economics, cost effectiveness and effectiveness of community interventions. This list is meant to be illustrative, not inclusive. Projects involving multidisciplinary teams, particularly those that span schools, are highly encouraged.
    • The Community Engagement component seeks to encourage community based research through collaborative relationships with community agencies such as community health centers, schools, county health departments and/or hospital systems or other local nonprofit health organizations. Award recipients are encouraged to follow the principles of Community Engagement and include project expenses that support the community partner’s role in the proposed project. Funding must be used to form new community-based partnerships, enhance existing partnerships or support the development, implementation, or evaluation of a community-based research project involving local health issues. Community Engagement grantees are required to present their projects at two Fall events, the Community Health Symposium as well as the Spectrum Annual Research Symposium.


Proposal Requirements/Submission:

By Wed., Oct. 30, 2013, please submit your application materials electronically as A SINGLE PDF file to Kathy Gillam, Ph.D. (kathy.gillam@stanford.edu).  

All Population Health Sciences, incl. Community Engagement seed grant proposals must include the following sections:

    • Title Page (Spectrum Innovation Accelerator Seed Grant Program)
      • Title of Proposal
      • Type of Proposal (Population Health Sciences, incl. Community Engagement)
      • PI Name, Title, Department, Contact
      • Mentor Name, Title, Department, Contact*
        *for Graduate Students and Postdoctoral Fellows
    • Research Plan
      Limit the total of the subsections (a-f) to 3 pages including any figures or tables; and excluding references
      • a. Structured Abstract (aims, methods, innovation, research plan/timeline)
      • b. Description of potential impact and likelihood of transition to independent funding
      • c. Description of interdisciplinary collaborations (if any)
      • d. Description of plan for community engagement (for Community Engagement awards)
      • e. Preliminary Data (if any)
      • f. Development Plan
    • Detailed Budget, Budget Justification and Name(s) of Dept/Divisional Financial Manager (1/2-1pg)
    • NIH Biosketches (4 page version) for PI and Co-Investigators
    • Letter of Commitment from Community Partner (for Community Engagement)

For specific questions regarding Community Engagement proposals, please contact Jill Evans, MPH (jille@stanford.edu)

 


 


 


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