Research Management Group (RMG)

Paul G. Allen Family Foundation
Allen Distinguished Investigators Program

This webpage contains the university-wide internal submission guidelines for the Allen Distinguished Investigators program.

The internal deadline has passed- this is for your reference only.

2014 Life Science Focus: Basic insights into neuronal maturation


# of applicants permitted:
2 (see internal submission guidelines at the end of this message)

Timeline:
Internal Stanford Neuroscience Institute deadline: Monday, Oct. 6, 2014, 5 p.m. (see internal submission guidelines below)
Sponsor’s deadline: Oct. 31, 2014

Guidelines
This RFP is not posted on the foundation’s website.
Download a PDF file of the guidelines >> pdf

Amount of funding: up to $1.5M total direct costs per project over 3 years
The foundation has a 0% indirect cost policy.

Eligibility:


Program/Description:


We seek proposals whose focus would provide insights into neuronal maturation in vitro, with an emphasis on human models (e.g. iPSCs, ESCs).

While in vitro systems are instrumental in revealing processes in healthy and disease states, currently the ability to fully understand and recapitulate neuronal cell maturation is inadequate (ex. neocortical development, disease). Recent studies reveal that cells can fail to maintain age-associated markers during reprogramming and differentiation, and be arrested or delayed at an immature developmental state. A variety of approaches have been used to induce cellular maturation (ex. stress, progerin), but it is unclear how closely these models mimic the normal maturation process.

While the focus here is on neuronal maturation, other relevant model systems will be considered if they have the potential to surface general underlying mechanisms, profiles or pathways. We are not interested in proposals that will result in incremental changes to existing technologies and methodologies.


Lines of Inquiry include (but are not limited to):

Methodological and technological advances are often necessary complements to scientific advance and yet these are often difficult to fund through traditional sources. The ADI Program encourages and supports researchers including novel methodological, theoretical and technological elements in their proposals. Supported projects are expected to have interim milestones and clearly described anticipated outcomes. Scientific goals in the topic area should be achievable within the award period.

NOTE: Applications must include a description of the proposed project, an explanation of how the proposed project fits in the research agenda focused on a topic area and why it has significant potential to ‘move the needle’ towards answering a broad scientific question posed for the cohort. Any interdisciplinary elements of the project should be described. The proposal should also include an explanation of why the proposed project is unlikely to receive funding through traditional sources.

INTERNAL SUBMISSION GUIDELINES

By Monday, Oct. 6, 2014, 5 p.m., please submit one PDF file containing the following in the order listed below to

Tanya Raschke
Associate Director for Planning and Operations
Stanford Neurosciences Institute (SNI)
raschke@stanford.edu
650-725-5926

File name: Last name_ADI_2014.pdf

1) Title Page
Paul G. Allen Family Foundation
Allen Distinguished Investigator Program
Project title:
PI name, title, department, address, phone and email
Co-PI name, title, department, address, phone and email

2) Proposal format (based on page 2 of the sponsor’s guidelines**)
We request that all submissions be on 8 . x 11 paper, using Times New Roman, a font size of 12 points, single spaced, and utilize 1” margins top, bottom, left and right.
Submissions will have the following proposal sections and associated length limits:
a. Technical project summary Short paragraph – (200 word limit)
b. Lay project summary and big picture impact Short paragraph – (200 word limit)
c. Project description* 5 pages [references are not included in the page count of the project description. Up to 10 figures are permitted. The figures must be included in an appendix, and will not count towards the page count]
d. Biographical sketch 3 pages (for each PI and co-PI)
h. Related prior and current grants 1 page
i. Collaboration 2 pages

(**Note: items e, f, g, and j will only need to be completed as part of the two final applicant’s full proposal.)


Selection process

Your proposals will be reviewed by the Stanford Neuroscience Institute internal review committee. That committee will select the two proposals to represent Stanford.

 

 

 

 

 

 

 

 

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