Research Management Group (RMG)

NIH Office of Research Infrastructure Programs
High-End Instrumentation Grant Program (S10) PAR-15-118

**A university-wide internal vetting process is required for all applications**
This program accepts applications from groups of NIH-supported investigators to purchase or upgrade a single item of expensive, specialized, commercially available instruments or integrated systems that cost at least $600,000. The maximum award is $2,000,000.See the special note below.

[See the separate internal vetting process required for the NIH Shared Instrumentation Grant program ($50K-$600K)-March 16th deadline-more >> ]

**New this year: the NIH requires for both the High End Instrumentation and Shared Instrumentation Grants that the PD/PI chosen for this application should have documented (in the biographical sketch) technical expertise directly related to the type of the chosen instrument. The PD/PI does not need to have an NIH research grant or any other research support but is expected to be an expert on the requested instrument. The PD/PI may be a Core director or non-tenured faculty member of the applicant organization. See eligibility.


Rare Exception-PI waiver request packet* deadline for Core Directors: March 16, 2015
*contact Jeanne Heschele at for the waiver request packe tinstructions.
University-wide internal deadline: Monday, March 23, 2015, 5 p.m. (see internal proposal guidelines below)
The following deadlines will only apply to "vetted"/approved proposals:
Application Due Date(s): May 29, 2015
Earliest Anticipated Start Date(s): Feb. 1, 2016

Program guidelines:
(see Stanford's eligibility requirement and internal vetting process below)


Amount of funding:
Applications will be accepted that request a single, commercially available instrument or integrated system which costs at least $600,000. There is no upper limit on the cost of the instrument, but the maximum award is $2,000,000. Since the cost of the various instruments will vary, it is anticipated that the size of the award also will vary.
Awards are for one year and for direct costs only. 10-15 awards will be made


The ORIP High-End Shared Instrument Grant (HEI) program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of expensive, specialized, commercially available instruments or integrated systems that cost at least $600,000. The maximum award is $2,000,000.


Types of instruments supported include, but are not limited to, X-ray diffraction systems, nuclear magnetic resonance (NMR) and mass spectrometers, DNA sequencers, biosensors, electron and confocal microscopes, cell-sorters, and biomedical Imagers.

Foreign made equipment is allowable.

The HEI program supports instruments for research purposes only.


# of applicants:


Eligibility criteria:


NEW this year** Special Use Instrument (SUI)
In rare special circumstances, to extend the outreach of the HEI Program to cases when an Institution cannot justify sole use of the high-end instrument for NIH-supported and other biomedical research, the Institution may contribute a portion of the cost of the requested instrument commensurate with the proposed use of the instrument for other than biomedical research. This rare request will be designated as a Special Use Instrument (SUI). In such situations:


The HEI program will not support requests for:


University-wide Internal Vetting Process Submission Guidelines

If you plan on submitting a proposal-please send a brief email alerting Jeanne Heschele about your instrument. Please also note if it is a "SUI-Special Use Instrument" request.

By Monday, March 23, 2015, 5 p.m. all faculty from all schools must send the following, in the order listed below, in one PDF file via email attachment to:

Jeanne Heschele
Research Management Group

File name: Last name_NIH_HEI_2015.pdf

Proposal format: single-spaced, 1/2 inch margins, Arial or Helvetica size 11 font or larger

1) Proposal (4 pages):
Name of the RFA: NIH High-End Instrumentation Grant Program (S10) PAR-15-118
PI name, title, department, address, email address
Proposal Title
Type of Instrument (make, model)
Estimated total cost (reminder: the base cost of the instrument should be at least $600,000)
Indicate if the instrument is a “SUI-Special Use Instrument"
Location of instrument (name of core facility, building location)
Major user groups, names, titles, departments (see eligibility: a major user group of three or more investigators who are Principal Investigators on active NIH research grants with the following activity codes, P01, R01, U01, R35, R37, DPI and DP2 must be identified.
Projects supported by NIH research grants should together require at least 75 percent of the Biomedical Research Time (BRT). The Major Users supported by NIH grants should require at least 35 percent of the BRT.

2) Letter of support from your department chair addressed to the NIH High End Instrumentation Internal Vetting Process Committee

3) Biosketch for the PI.
This biosketch should document the required technical expertise for the proposed instrument.

4) Copy of the approved "Rare Exception PI waiver request packet" - this applies only If the PI is the Core (Service Center/Shared Facility) Director is the PI for the proposal because he/she has the required, documented technical expertise for the proposed instrument and a faculty member does not)
If you are a Core Director and will be the PI for the NIH SIG proposal because a faculty member does not meet the criteria, please contact Jeanne Heschele at for instructions on obtaining a Rare Exception PI waiver so that you have time to request and obtain approval for the waiver so a copy of the request can be attached to your proposal. (The procedure varies.)

5) For Resubmissions ONLY.
Please see the “resubmission” policy in the guidelines (about checking with your program officer and discussing the new requirement that this year, the PI must have documented evidence in your attached biosketch that you have the technical expertise that is directly related to the type of instrument chosen, and if, you’ll have to have someone who meets the criteria be the PI. If that PI is a Core Director, then that Core Director will need to contact me to obtain instructions for obtaining a “Rare Exception PI waiver” request. If you have the required expertise and want to “resubmit” your HEI proposal- for this internal vetting process you will:

  • include an Introduction describing the changes that have been made in response to comments in the previous review.
  • obtain new letter of support per instructions (#2 above)
  • attach the previous internal vetting process proposal


Selection Process

Jeanne Heschele will be the point person for ALL HEI internal proposals from ALL schools.
She will compile master lists of instruments, including separate lists for each school, and identify any duplicate instrumentation requests. Jeanne will distribute the proposals to: School of Medicine's, Humanities and Sciences', and the School of Engineering Dean's Offices'. Each school will have it's own respective internal review "vetting" committee. Each school's Dean's office will inform their respective PIs if their proposal is approved or not.

Duplicate proposals: If any of the proposals are duplicates, each school will then send ONLY the "vetted" duplicate proposals to the Dean of Research Office internal review committee. The DoR internal review committee will determine which of the duplicate instrumentation proposals is the strongest.

Only proposals which are approved by the vetting process will be able to submit their full applications.

Stanford Resources:

Shared Facility/Core Facility Resource
You are encouraged to discuss shared facility, service center, core facility resources with Bruce Koch, Senior Director, Discovery and Technological Services Centers, Office of the Senior Associate Dean for Research in the School of Medicine at

Property Management Office (PMO) as a resource:
You are also encouraged to use your Department Property Administrator (DPA) or Property Service Representative in the Property Management Office (PMO) as resources. They can generate an inventory list of existing instruments similar to the one you are proposing that includes locations, and "stewards". To find your DPA or PMO Property Service Representative contacts:

DoResearch Shared Facility webpage:

School of Medicine/Spectrum webpage "Enabling Technologies" (includes links to shared facilities):

School of Medicine Service Centers links:




Stanford Medicine Resources:

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