Research Management Group (RMG)

NIH Office of Research Infrastructure Programs
National Institute of General Medical Sciences (NIGMS)
High-End Instrumentation Grant Program (S10) PAR-18-598

**A university-wide internal vetting process is required for all applications**
This program accepts applications from groups of NIH-supported investigators to purchase or upgrade a single item of expensive, specialized, commercially available instruments or integrated systems that cost at least $600,001. The maximum award is $2,000,000. See the eligiblity section below >>.


Internal vetting process for other S10 programs:

Timeline:

Program guidelines:
Important: please see Stanford's eligibility requirements and internal vetting process guidelines below.
Program announcement:
https://grants.nih.gov/grants/guide/pa-files/PAR-18-598.html


HEI award recipients (FY2006-2016)

http://dpcpsi.nih.gov/orip/dicc/fy_hei_awards

 

Amount of funding:
Applications will be accepted that request a single, commercially available instrument or integrated system which costs at least $600,001. There is no upper limit on the cost of the instrument, but the maximum award is $2,000,000. Since the cost of the various instruments will vary, it is anticipated that the size of the award also will vary.   Awards are for one year and for direct costs only.
ORIP intends to commit about $30 million in FY 2018 to fund an estimate of 25 awards.


Number of applicants:
Even though the program announcement indicates unlimited applications are permitted (no duplicate instruments), the university is requiring a vetting process.

Only internal "vetted" proposals approved by internal review committee(s) will be able to submit a subsequent full application.


Why the vetting process is necessary:

There is no restriction on the number of applications an institution can submit to the SIFAR, SIG or HEI Programs each year provided the applications request different types of equipment. However, concurrent SIFAR, SIG and/or HEI applications for the same instrument (or the same type of instrument with added special accessories to meet the HEI budget requirement) are not allowed, in general. If two or more S10 (either SIFAR, S IG or HEI) applications are submitted for similar equipment from the same institution, documentation from a high level institutional official must be provided stating that this is not an unintended duplication, but part of a campus wide instrumentation plan. [Jeanne Heschele will assist PIs with obtaining a letter of support from Dr. Arvin justifying any similar instrument requests.] The vetting process will also confirm the PI for the proposed instrumentation has the documented technical expertise related to the proposed instrument.


Purpose:

The ORIP High-End Shared Instrument Grant (HEI) program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of expensive, specialized, commercially available instruments or integrated systems that cost at least $600,001. The maximum award is $2,000,000.

The objective of the Program is to make available to institutions expensive research instruments that can only be justified on a shared-use basis and that are needed for NIH-supported projects in basic, translational or clinical areas of biomedical/behavioral research. The HEI Program provides funds to purchase or upgrade a single item of expensive, specialized, commercially available instrument or an integrated instrumentation system. An integrated instrumentation system is one in which the components, when used in conjunction with one another, perform a function that no single component could provide. The components must be dedicated to the system and not used independently.

 

Types of instruments supported include, but are not limited to:

Applicants are advised to discuss with the HEI Scientific/Research Contact (see the guidelines) any questions about appropriate types of equipment, eligibility, and Program requirements, prior to submitting an application.


Eligibility criteria:

 

Special Use Instrument (SUI)
In rare special circumstances, to extend the outreach of the HEI Program to cases when an Institution cannot justify sole use of the high-end instrument for NIH-supported and other biomedical research, the Institution may contribute a portion of the cost of the requested instrument commensurate with the proposed use of the instrument for other than biomedical research. This rare request will be designated as a Special Use Instrument (SUI). In such situations, the instrument’s Biomedical Research Time (BRT) must be at least 50% of the Accessible User Time (AUT) or the portion of the NIH funds of the cost of the instrument, whichever is larger. Definitions of how to calculate BRT and AUT appear in Section IV in the "Justification of Need" Section of the Instrumentation Plan. If an Institution makes a request for SUI, the non-NIH funds must not be less than 25% of the total instrument price. All other requirements outlined in this FOA still apply.

The non-biomedical research activities supported by the instrument may include research in other fields, curricular instructions, and billable clinical care. The Institution must provide specific long term plans to secure and protect access to the instrument for biomedical researchers, as detailed in Section IV.2 under "SUI Request".

If an Institution is considering a SUI request, the applicant is strongly advised to consult with Scientific/Research Contact(s) and Financial/Grants Management Contact(s) (see Section VII) before submitting an application as it is likely that special administrative procedures will have to be followed.

If an Institution is considering a SUI request, the applicant is strongly advised to consult with Scientific/Research Contact(s) and Financial/Grants Management Contact(s) before submitting an application as it is likely that special administrative procedures will have to be followed.

 

The HEI program will not support requests for:

 

INTERNAL VETTING PROCESS GUIDELINES

If you plan on submitting a proposal-please send a brief email alerting Jeanne Heschele about your instrument. Please also note if it is a "SUI-Special Use Instrument" request.

By Tuesday, March 20, 2018, all faculty from all schools must send the following, in the order listed below, in one PDF file via email attachment to:

Jeanne Heschele
Research Management Group
jheschele@stanford.edu
650-245-2351

File name: Last name_NIH_HEI_2018.pdf

Proposal format: single-spaced, 1/2 inch margins, Arial or Helvetica size 11 font or larger

1) Proposal (up to 5 pages):
Name of the RFA: NIH High-End Instrumentation Grant Program (S10) PAR-18-598
PI name, title, department, address, email address
Proposal Title
Type of Instrument (make, model)
Estimated total cost (reminder: the base cost of the instrument should be at least $600,001)
Indicate if the instrument is a “SUI-Special Use Instrument"
Location of instrument (name of core facility, building location)
Proposal should also include a narrative: introduction, scientific purpose, justification of the need.
Major user groups, names, titles, departments (see eligibility: a major user group of three or more investigators who are Principal Investigators on active NIH research grants must be identified.
To demonstrate the clear need for the requested instrument, the projects supported by NIH research grants should together require at least 75 percent of the Accessible User Time (AUT). Major Users supported by NIH grants should together require at least 35 percent of the AUT.

2) Letter of support from your department chair addressed to the NIH High End Instrumentation Internal Vetting Process Committee


3) Biosketch for the PI.
This biosketch should document the required technical expertise for the proposed instrument.
Reminder- multiple PIs are not permitted.


4) List of similar instruments:
Instructions for obtaining the list:  by March 12, 2018, PIs should contact Stan Dunn in the Property Management Office at standunn@stanford.edu (see the timeline above) and request that he generates a list of similar instruments for you. Please provide the specific manufacture/model of the instrument. If examples of similar instruments can also be provided, that is very helpful. Stan will provide you with a memo containing the search terms and results that must be included with your internal vetting process proposal. (You are encouraged to obtain this early on in the process but please request no later than March 12.)

NOTE: This list is requested because the "Justification of need" section of the application, which requires that PIs "provide an inventory of similar instruments existing at your institution, neighboring research institutions, or otherwise accessible; describe why each similar instrument is unavailable or inappropriate for the proposed research.” If similar instruments are listed as 'unavailable', PIs will need to include in their final applications (see the Letters of Support section in the guidelines) from each instrument manager (core director) explaining why the instrument is not available to your user group.

5) Copy of the approved "Rare Exception PI waiver request packet" - this applies only If the PI is the Core (Service Center/Shared Facility) Director is the PI for the proposal because he/she has the required, documented technical expertise for the proposed instrument and a faculty member does not). Core Directors-download the Rare Exception PI waiver-Core Director HEI instructions >>.   pdf

6) For Resubmissions ONLY.
Please see the “resubmission” policy in the guidelines (about checking with your program officer and discussing the new requirement that this year, the PI must have documented evidence in your attached biosketch that you have the technical expertise that is directly related to the type of instrument chosen, and if, you’ll have to have someone who meets the criteria be the PI. If that PI is a Core Director, then that Core Director will need to contact me to obtain instructions for obtaining a “Rare Exception PI waiver” request. If you have the required expertise and want to “resubmit” your HEI proposal- for this internal vetting process you will:

  • include an Introduction describing the changes that have been made in response to comments in the previous review.
  • obtain new letter of support per instructions (#2 above)
  • Request a list of similar instruments: (per the instruction for # 4 above >>) by March 12th, PIs should contact Stan Dunn in the Property Management Office at and request that he generates a list of similar instruments.
  • attach the previous internal vetting process proposal
  • attach the previous approved "Rare Exception PI waiver" request, if applicable

 


Selection Process
All of the Stanford University SIFAR, SIG and HEI proposals will be reviewed and vetted and will be notified about the status of the proposals as soon as possible after the internal vetting deadline.  Only proposals which are approved by the vetting process will be able to submit their full applications.

 

Stanford Resources:

Institutional Representatives:
You are encouraged to notify your RPM as soon as possible that you will be submitting a proposal so he/she can begin to generate your budget and assist with other aspects of your application.
SoM Internal proposal submission policy change webpage >>
Research Process Manager (RPM) department assignment webpage >>

Faculty in other schools: Download the Pre-award OSR department assignments on this DoResearch webpage >>

Shared Facility/Core Facility Resource
You are encouraged to discuss shared facility, service center, core facility resources with Bruce Koch, Senior Director, Discovery and Technological Services Centers, Office of the Senior Associate Dean for Research in the School of Medicine at bruce.koch@stanford.edu.

Property Management Office (PMO) as a resource:
Per #4 above >>, contact Stan Dunn in the Property Management Office asap to generate a list of similar instruments for you.

DoResearch Shared Facility webpage:
http://doresearch.stanford.edu/research-scholarship/shared-facilities

School of Medicine/Spectrum webpage "Enabling Technologies" (includes links to shared facilities): http://spectrum.stanford.edu/page_listings/enabling-technologies

School of Medicine Service Centers links: http://corefacilities.stanford.edu/

 

 

 

 



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