National Institute of Health (NIH)
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Core Centers for Musculoskeletal Biology and Medicine (P30)
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Program announcement: NIH website
# of applicants permitted: 1
This is a reissuance of a program announced in Nov. 2004.
Internal Deadline: May 12, 2008 (see internal submission guidelines below)
Letters of Intent Receipt Date: June 30, 2008
Application Receipt Date: July 30, 2008
Amount of funding:
Approximately $1.8 million in total costs (Direct costs plus Facilities and Administrative costs) may be awarded in support of this solicitation. Three new and/or renewal (competing continuation) grants are anticipated. Direct costs of up to $400,000 per year may be requested, with a total project period of 5 years. (This includes up to $100,000 yearly in direct costs for pilot and feasibility studies.)
Eligibility:
Stanford faculty with PI eligibility.
Purpose:
The Core Centers for Musculoskeletal Biology and Medicine (CCMBMs) will provide shared facilities and services to groups of established, currently funded investigators addressing scientific problems in musculoskeletal biology and medicine, in order to improve efficiency, accelerate the pace of research, and ensure greater productivity. Core Centers also support pilot and feasibility studies and program enrichment activities.
Research Core Centers could potentially facilitate projects in many areas of musculoskeletal biology and medicine: the skeleton, muscles, connective tissues such as tendon and ligament, cartilage surfaces of joints and the intervertebral discs of the spine.
The Division of Musculoskeletal Diseases of the NIAMS supports research aimed at improving the diagnosis, treatment, and prevention of diseases and injuries of the musculoskeletal system and its component tissues. Key public health problems addressed by this research include osteoporosis, osteoarthritis, and muscular dystrophy. Core Centers for Musculoskeletal Biology and Medicine are intended to combine and provide additional resources for research into these areas of human health.
An Administrative Core should be proposed to coordinate the Center and administer the program enrichment activities. CCMBM Directors are encouraged to propose a broad research base that includes multiple disciplines, departments, and institutions.
Two or more research cores must be proposed.
A research core is a facility shared by two or more Center investigators that enables them to conduct their independently funded individual research projects more efficiently and/or more effectively.
Cores generally fall into one of four categories:
(1) provision of a technology that lends itself to automation or preparation in large batches (e.g., histology, tissue culture, high throughput sequencing, and genotyping);
(2) complex instrumentation (e.g., electron microscopy, flow cytometry, confocal microscopy, whole animal imaging, microarray scanning, and mass spectrometry);
(3) animal preparation (including transgenic and knockout) and care; and
(4) methodology cores (e.g., molecular biology, systems biology, bioinformatics, biostatistics, and clinical).
CCMBM Directors are encouraged to leverage existing resources, such as registries, tissue banks and cohorts, and to coordinate with NIAMS-funded Skin and Rheumatic Disease Cores at the same and/or other institutions, particularly if they provide similar or overlapping technologies and services.
A pilot and feasibility study program provides modest research support ($20,000 - $50,000 direct costs yearly) for a limited time (1 to 3 years) to enable eligible investigators to explore the feasibility of a musculoskeletal-related concept and amass sufficient data to pursue it through other funding mechanisms. The initial set of pilot and feasibility studies must be part of the application. In addition, a plan for program management of the pilot and feasibility program will also be reviewed. The plan must include review of future pilot and feasibility applications during the tenure of the Core Center.
Internal submission guidelines:
By Monday, May 12, 2008, please submit the following one page document electronically via email attachment to Jeanne Heschele at jheschele@stanford.edu:
One page document which includes:
- Descriptive title of proposed research
- Principal Investigator(s)
(Title, department, address, email, phone numbers)
- Description of the two or more Research Cores you wish to propose.
- Key public health problems addressed by your proposal and how your Core Centers will provide additional resources for research into these areas.
Selection Process
Your proposals will be reviewed by Dr. Harry Greenberg, Senior Associate Dean for Research. The applicant selected to represent the School of Medicine will be notified so that he/she will be able to submit a letter of intent to the NIH by June 30, 2008 and a complete application by July 30, 2008.
