Doris Duke Charitable Foundation (DDCF)
Innovations in Clinical Research Award (sickle-cell research)
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**New $486K funding opportunity for Stanford faculty with PI eligibility who propose clinical research studies of sickle-cell disease. See eligibility, research studies of interest, and definition of clinical research below.***
Unlimited letters of intent are permitted.
Timeline:
Letters of intent deadline (required): March 14, 2013, 3 p.m. EDT
Investigators who submitted LOIs will be sent instructions by March 20th regarding how to submit a full proposal.
Full proposal deadline: May 13, 2013, 3 p.m. EDT
Institutional representative: you do not have to submit your letter of intent through your institutional representative. However, you must submit your full proposal through your institutional representative.
Guidelines >>
**Note: please read the Stanford clarification in the eligibility criteria below first.**
Amount of funding:
$150,000 per year for 3 yrs to support direct research expenses including salary support, plus $12,000 (8%) for indirect costs. $450,000 total direct costs plus $36,000 total indirects= $486,000 total costs
Up to 10 awards to be made.
Purpose:
The ICRA invites clinical research proposal that have the potential to catalyze innovative breakthroughs in sickle cell disease. Proposals may be for exploratory projects that do not have extensive preliminary data but have potential for high impact. Recent advances in stem cell research, genetics and genomics, pharmacogenetics, and medicinal chemistry offer promise to further our understanding of the mechanism of disease, genetic variability of disease symptoms and new drug targets.
- Faculty with PI eligibility.
- Applicants must hold an advanced doctoral degree (M.D., Ph.D., M.D./Ph.D., DO or equivalent)
- Stanford clarification: Instructors are not eligible. Although the guidelines state "full-time faculty-level Instructors are eligible", here at Stanford, Instructors are not faculty level positions. Also, this is a research grant and not a mentored career development award, so Instructors would not be eligible to request a Career Development PI waiver in order to apply.
- Applicants must propose a research project that meets the DDCF's definition of clinical research (see below)
- Applicants can only submit one proposal as PI (or co-PI if applying as a team*)
- *Application from teams: A team application is not required. When a project has more than one principal investigator who will share the responsibility for leading and directing the research, an application can be submitted for up to two co-PIs. However, the letter of intent must be submitted by the PI who would administer the grant if awarded and that meets all of the eligibility criteria above.
ANIMAL RESEARCH RESTRICTIONS:
Important Note--Experiments that utilize animals or primary tissues derived from animals will not be supported by this program.FAQ clarification: My preliminary research has included research in animal models. Can I include this in my proposal? Yes. Preliminary research in animal models may be included in your application. However, no DDCF funds may be used for experiments that utilize animals or primary tissues derived from animals. If you are planning animal studies concurrent to your proposed ICRA research and mention these in your proposal, you must clearly state that these will be supported by other funds and include the source of these funds.
Definition of Clinical Research:
Clinical research involves the scientific investigation of the etiology, prevention, diagnosis, or treatment of human disease using human subjects, human populations or materials of human origin. Included in the definition are studies that utilize tissues or pathogens only if they can be linked to a patient.
Research studies of interest:
Research Studies of interest to the foundation include, but are not limited to, the following investigations of sickle cell disease:
- Novel strategies to better understand the biology and mechanism of disease
- Drug discovery and development of new therapeutics
- Disease heterogeneity
- Corrective approaches such as gene therapy and transplantation of blood-forming cells
- Identification and clinical validation of new risks for disease complications
- Development or improvement of validated endpoints ("gold standards") for clinical studies
- Prevention or reversal of organ damage
- New approaches to improve blood transfusion
- Stroke prevention
- Diagnosistic and treatments for use in low-resource settings
They strongly encourage the following cross-disciplinary work:
- Development of new treatments or approaches drawing from innovations in other fields
- Crossover of researchers from other disciplines and specialties to work on sickle cell disease
Funding Information Resources for the Stanford community:
Includes links to webpages created for this and other announcements; searchable funding databases, limited submission programs, internal Stanford funding opportunities, NIH and NSF resource links, etc.
http://med.stanford.edu/rmg/funding/
Institutional Representatives
You do not have to submit your letters of intent via your RPM or OSR representative. However, you must submit your application materials and your completed PDRF forms to your institutional representative at least 5 working days prior to the application deadline. You are strongly encouraged to let your RPM know as soon as possible that you are planning to submit an application so they can help with your budget preparation, etc.
*Medicine: RPM Assignments by department: http://med.stanford.edu/rmg/rpmmaster.html
*Other schools: OSR assignments: http://ora.stanford.edu/ora/osr/contact.asp
Foundation Relations: MCD and LPFCH
The Foundation Relations team in the Medical Center Development office is available to assist School of Medicine faculty with a review and editing of your proposal. This office facilitates mutually beneficial relationships between faculty and private and philanthropic organizations. Please contact Joy Morimoto at 650-736-9749, joym@stanford.edu, or Michelle Heeseman at 650-736-8968, Heeseman@stanford.edu, for assistance.For assistance with proposals in children’s health research, please contact Ann Rose ann.rose@lpfch.org 650-497-8444 or Edna Neivert Edna.Neivert@LPFCH.ORG 650-724-2783 in Foundation Relations at Lucile Packard Foundation for Children’s Health.
Shared Facility/Service Center Resource
You are encouraged to discuss shared facility, service center, core facility resources with Bruce Koch, Senior Director, Discovery and Technological Service Centers, Office of the Senior Associate Dean for Research at bruce.koch@stanford.edu.
