Research Management Group (RMG)

The Dana Foundation
David Mahoney Neuroimaging Program:
Using Brain and Immune Imaging to Improve Human Health

**Limited funding opportunity for Stanford assistant professors and associate professors (within the first few years of their appointment) with PI eligibility. Funds support pilot-testing by investigators who are early in their research careers of promising, high-risk, and innovative ideas with a direct clinical application. Investigations must be applicable to human brain or brain-immune functioning or malfunctioning to be considered for funding. **

This webpage contains the internal selection process held in early 2014 and is for your reference only. It will be updated when the 2015 program is announced.

Internal SINTIN deadline: Friday, January 31, 2014, 12 noon (see internal submission guidelines below)
Sponsor's preliminary application deadline: Feb. 25, 2014, 12 noon
Applicants will be informed within ten weeks of the preliminary proposal deadline on whether they are invited to prepare full proposals.
First awards announced in Sept. 2014

# of applicants: 1 applicant is permitted (see internal submission guidelines)
The applicant selected to represent Stanford can be from either of the following categories or both.



Amount of funding:
$200,000 payable over 3 yrs
The Foundation does not provide support for indirect costs. However, up to 10 percent of the total grant award may be used to purchase equipment for the study.

The Dana Foundation’s neuroimaging research program focuses on improving human brain and brain-immune functioning to promote health, and prevent and treat disease. Funds support pilot-testing by investigators who are early in their research careers of promising, high-risk, and innovative ideas with a direct clinical application.

The program is designed to enable investigators to obtain pilot data more quickly than is possible through other funding processes. Submitted proposals should focus on imaging in patients or patient tissues, and healthy volunteers.

Applications for animal model studies of brain conditions or injuries will be considered only if they relate directly to humans but cannot yet feasibly be undertaken in humans, and are anticipated to be translated into human research following the three-year grant period. Such studies include research on: 1) normal brain anatomy and physiology in the animal model that can help to better understand the roles of cells and networks in specific cognitive functions and how these are altered by disease and injury; and 2) animal models of human diseases either through transgenic methods or through naturally occurring or induced disease states that are directly related to the human condition.

Topics of interest
Previously funded studies under this Program have focused primarily on:
1) understanding normal brain functioning, how it is altered by disease or injury, and how it recovers or repairs;
2) assessing and improving diagnostic and therapeutic approaches; and
3) refining and advancing imaging technologies to address specific clinical questions.
In addition to these three general areas of continued interest, it is becoming increasingly apparent that neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, and mental illnesses such as schizophrenia and depression start long before they are clinically evident. The Foundation, therefore, encourages studies that seek to understand developmental processes of disease, surrogate measures of early disease existence, and measures of disease progression. Also, for chronic traumatic encephalopathy and Alzheimer's disease, the role of tau is becoming of increasing interest and the Foundation is receptive to considering studies on how to image tau.

Tips for applicants:

What they do not fund

Internal submission guidelines

By Friday, Jan. 31,, 2014, 12 noon., please submit one PDF file containing the following in the order listed below to:

Tanya Raschke
Stanford Neurosciences Institute
Associate Director for Planning and Operations

You do NOT have to prepare a budget, or generate a PDRF form, or work with your institutional representative (RPM). You can submit your internal proposal per these instructions.

Format: using at least 11-point font size (font sizes smaller than that will not be reviewed) and .5 inch margins in all directions with numbered pages

1) Title Page (page 1)
Title of this RFA: The Dana Foundation David Mahoney Neuroimaging Program
Project Title:
Imaging Category: structural/physiological or cellular/molecular, or a combination of both
Imaging technique: such as fMRI, two-photon, etc.
Investigator(s) name(s), title(s), department, phone and fax numbers, E-mail, and street address.

2) Proposal (pages 2-4)
Section I: A clearly and succintly stated hypothesis;
Section II: The aims of the proposed research project. What disease(s), disorder(s) or injuries would be better understood, diagnosed, or treated? Or, what normal brain function or brain-immune interaction would be better understood? Or, what imaging technology would be refined and for what specific purposes? Such technology development or modification aims need to be accompanied by initial evidence of the project’s feasibility.
Section III: The research significance and potential clinical application(s) of the research
Section IV: The methods. Please clearly describe the research design and specify tests and analyses proposed to develop the pilot data. If enrollment of human participatns is planned, please provide preliminary evidence that the number required can be recruited from the participating institution(s).
Section V: The qualifications of the primary investigator(s) for undertaking the proposed research. What facilities and resources at the applicant institution(s) would be used in the research? Please provide evidence that required technologies would be available for this project.

3) Additional pages
Appendix A: a list of all active grants and pending proposals by the applicant(s). Please include an abstract that specifies the aims for any existing or pending grants from these sources of support that are related to, or could potentially overlap with, the proposed Dana study.
Appendix B: Please provide a standard NIH four-page format CV for the primary investigator(s)
Appendix C: You may include up to two additional pages to list relevant references.
Appendix D of the preliminary proposal will permit glossy photos. However, those glossy photos are not required for the internal selection process.

Selection process

Your proposals will be reviewed by the Stanford Neuroscience Institute Advisory Committee. The sponsor's preliminary proposal guidelines request additional information from the applicant selected to represent Stanford. The final applicant selected will need to factor in time to prepare that additional information and obtain his/her RPM's signature and Dr. Minor's signature on his/her preliminary proposal.



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