Movies of Narcolepsy/Cataplexy
Find out how Bear, a dog that naps hundreds of times a day due to narcolepsy, may just help solve the mystery of the disease's cause in humans (courtesy of the Discovery Channel show: "Is It Possible?") MOVIE
- Zebrafish. While not narcoleptic, we are using the zebrafish as a genetic model to dissect the hypocretin system. Do fish sleep? Check out the MOVIE
One of the ways that we can examine if the neurobiology of sleep is similar in fish and humans is to examine how how fish respond to hypnotic drugs. Here is a MOVIE showing the effects of a blocker of a histamine H1 receptor (mepyramine, Left panel) versus untreated fish (Right panel). Here is another MOVIE showing the effects of a GABA-B receptor agonist (R-baclofen, Left panel) versus untreated fish (Right panel). Both of these drugs cause sleepiness in humans. The video speed is 100x.
Various narcoleptic episodes in dogs. Sporadic cases of narcolepsy in dogs is due to hypocretin peptide deficiency while the familial form is due to mutations in one of the two hypocretin receptor genes (hcrtr2). Various dogs are shown here in a clip narrated by Dr. Mignot. MOVIE
A 3 year old narcoleptic weimaraner with hypocretin deficiency. The dog is doing the "Food-Elicited Cataplexy Test" that we use to quantify cataplexy in dogs MOVIE
Narcoleptic mice. This mouse model is a preprohypocretin knockout and exhibits both cataplexy and fragmented sleep wake, as in human narcolepsy (courtesy of Dr. Yanagisawa, Texas) MOVIE
- 9 year old child. Note that narcolepsy-cataplexy started when this child was 6 months old. This case is the only known child with a mutation in the preprohypocretin gene (courtesy of Dr. Nevsimalova, Prague, Czech Republic) MOVIE