Mark Nicolls

Clinical Focus

• Pulmonary Critical Care
• Pulmonary Medicine
• Lung Transplantation
• Heart-Lung Transplantation
• Transplantation Immunology

Administrative Appointments

• Program Director, Pulmonary and Critical Care Fellowship (2009 - present)
• Faculty, Vera Moulton Wall Center For Pulmonary Vascular Disease (2007 - present)
• Member, Stanford Cardiovascular Institute (2007 - present)
• Director, Lung Immunology (2007 - present)
• Joint Appointment, Immunology & Rheumatology (2007 - present)
View All 6administrative appointments of Mark Nicolls

Professional Education

Postdoctoral Advisees

Xinguo Jiang , Mohammad Khan , Wen Tian

Graduate & Fellowship Program Affiliations

• Immunology

Research Interests

Our lab focuses primarily on the contribution of the immune response to lung disease. We are specifically examining the contribution of inflammation to the development of pulmonary hypertension. We also study how airway remodeling occurs in transplantation with specific respect to the microvascular circulation and to the initiation of fibroproliferation.

Publications

• Increased regulatory and decreased CD8+ cytotoxic T cells in the blood of patients with idiopathic pulmonary arterial hypertension. Ulrich S, Nicolls MR, Taraseviciene L, Speich R, Voelkel N. Respiration. 2008; 75 (3): 272-80
• Microvascular destruction identifies murine allografts that cannot be rescued from airway fibrosis. Babu AN, Murakawa T, Thurman JM, Miller EJ, Henson PM, Zamora MR, Voelkel NF, Nicolls MR. J Clin Invest. 2007; 117 (12): 3774-85
• Oxidant stress, immune dysregulation, and vascular function in type I diabetes. Nicolls MR, Haskins K, Flores SC. Antioxid Redox Signal. 2007; 9 (7): 879-89
• Transfer of allograft specific tolerance requires CD4+CD25+T cells but not interleukin-4 or transforming growth factor-beta and cannot induce tolerance to linked antigens. Hall BM, Plain KM, Verma ND, Tran GT, Boyd R, Robinson CM, Nicolls MR, Berger ME, Nomura M, Hodgkinson SJ. Transplantation. 2007; 83 (8): 1075-84
• The matrix comes to lung transplantation. Babu AN, Nicolls MR. Transplantation. 2007; 83 (6): 683-4