E. John Harris Jr.

Clinical Focus

• Vascular Surgery

Administrative Appointments

• President, Northern California Vascular Society (2003 - 2005)
• President-Elect, Norther California Vascular Society (2001 - 2003)

Professional Education

Graduate & Fellowship Program Affiliations

• Surgery

Industry Relationships

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Research Interests

I am interested in the role of thrombosis in stimulating venous wall morphologic change. Our preliminary data suggests thrombin, which is biologically active and intercalated in the thrombus, stimulates thrombin receptors in the venous wall leading to wall thickening. We have a model of DVT in the rat we are investigating and we are using a similar model in mice, some of which are knockouts and transgenics with various risk factors for thrombosis deleted or overexpressed. We are looking to develop new ways to prevent chronic venous wall thickening following DVT, which we see with ultrasound studies in patients with post-thrombotic venous insufficiency.I also have an interest in non-invasive vascular imaging. Current projects include the development of a 3-D color Duplex ultrasound and evaluation of differential arterial blood flow during moderate exercise using real time MRI and a special visualizer software program. We are evaluating and comparing differential flow increases in normal volunteers and patients with intermittent claudication. Such a tool could then be used to evaluate the efficacy of certain treatments for claudication.

Clinical Trials

• Endovascular repair of abdominal aortic aneurysm with angled aorta, angled aneurysmal body or both. Recruiting
• Study of Zenith® Low Profile AAA Endovascular Graft to treat abdominla aortic aneurysm Recruiting
• Compare the outcome of bypass surgery and plaque excision for treatment of critical limb ischemia in the lower limbs Completed
• Endovascular Repair of Abdominal Aortic Aneurysms Completed
• Safety and efficacy study of a 31mm bifurcated endoprosthesis system in the treatment of infrarenal abdominal aortic aneurysms No longer recruiting

Publications

• Major blood vessel reconstruction during sarcoma surgery. Song TK, Harris EJ, Raghavan S, Norton JA. Arch Surg. 2009; 144 (9): 817-22
• Simulation-based endovascular skills assessment: the future of credentialing? Tedesco MM, Pak JJ, Harris EJ, Krummel TM, Dalman RL, Lee JT. J Vasc Surg. 2008; 47 (5): 1008-1; discussion 1014
• Anatomic suitability of ruptured abdominal aortic aneurysms for endovascular repair. Slater BJ, Harris EJ, Lee JT. Ann Vasc Surg. 2008; 22 (6): 716-22
• Intraoperative monitoring of elephant trunk kinking with transesophageal echocardiography. Oakes DA, Sze DY, Frisoli JK, Mitchell RS, Harris EJ, Thu C, van der Starre PJ. J Cardiothorac Vasc Anesth. 2007; 21 (4): 584-6
• Long-term thrombotic recurrence after nonoperative management of Paget-Schroetter syndrome. Lee JT, Karwowski JK, Harris EJ, Haukoos JS, Olcott C. J Vasc Surg. 2006; 43 (6): 1236-43