Zijie Sun

Postdoctoral Advisees

Mi Kyung Kwak , Yue Peng , Der Thor

Graduate & Fellowship Program Affiliations

• Cancer Biology
• Genetics
• Urology

Research Interests

Transcriptional control is a key step in the regulation of eukaryotic gene expression. My laboratory focuses on understanding the molecular mechanism of transcription factors that govern the transformation of normal mammalian cells to neoplastic state. We are particularly interested in the action of nuclear hormone receptors and the interactions between the receptors and other signaling pathways during tumor development and progression. Our long-term goal is to identify new diagnostic and therapeutic strategies for human cancers.

Clinical Trials

• Identification and Characterization of Novel Proteins in Head and Neck Cancer Recruiting

Publications

• The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development. Beliakoff J, Lee J, Ueno H, Aiyer A, Weissman IL, Barsh GS, Cardiff RD, Sun Z. Mol Cell Biol. 2008; 28 (1): 282-92
• The novel PIAS-like protein hZimp10 is a transcriptional co-activator of the p53 tumor suppressor. Lee J, Beliakoff J, Sun Z. Nucleic Acids Res. 2007; 35 (13): 4523-34
• A promoting role of androgen receptor in androgen-sensitive and -insensitive prostate cancer cells. Li TH, Zhao H, Peng Y, Beliakoff J, Brooks JD, Sun Z. Nucleic Acids Res. 2007; 35 (8): 2767-76
• The androgen receptor negatively regulates the expression of c-Met: implications for a novel mechanism of prostate cancer progression. Verras M, Lee J, Xue H, Li TH, Wang Y, Sun Z. Cancer Res. 2007; 67 (3): 967-75
• Roles and regulation of Wnt signaling and beta-catenin in prostate cancer. Verras M, Sun Z. Cancer Lett. 2006; 237 (1): 22-32