Philip Beachy

Administrative Appointments

• Member, Institute for Stem Cell Biology and Regenerative Medicine (2006 - present)
• Member, Stanford Cancer Center (2006 - present)

Honors and Awards

• March of Dimes Prize in Developmental Biology, March of Dimes Birth Defects Foundation (2008)
• Fellow, American Academy of Arts and Sciences (2003)
• Member, National Academy of Sciences (2002)
• National Academy of Sciences Award in Molecular Biology, National Academy of Sciences (1998)
• Outstanding Young Scientist Award, Maryland Academy of Sciences (1997)

Professional Education

Postdoctoral Advisees

Benjamin Myers , Chen Zhao

Graduate & Fellowship Program Affiliations

• Developmental Biology

Industry Relationships

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Research Interests

My lab studies the function of Hedgehog proteins and other extracellular signals in morphogenesis (pattern formation) and in injury repair and regeneration (pattern maintenance). We study how the distribution of such signals is regulated in tissues, how cells perceive and respond to distinct concentrations of signals, and how such signaling pathways arose in evolution. We also study the normal roles of such signals in stem-cell physiology and their abnormal roles in the formation and expansion of cancer stem cells.

Publications

• Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Peacock, C.D., Wang, Q., Gesell, G.S., Corcoran-Schwartz, I.M., Jones, E., Kim, J., Devereux, W.L., Rhodes, J.T., Huff, C.A., Beachy, P.A., Watkins, D.N., Matsui, W.. Proc. Natl. Acad. Sci. U.S.A.. 2007: 104 4048-4053
• Prevalence of off-target effects in Drosophila RNA interference screens. Ma, Y., Creanga, A., Lum, L., Beachy, P.A.. Nature. 2006: 443 359-363
• Structure of a heparin-dependent complex of Hedgehog and Ihog. McLellan, J.S., Yao, S., Zheng, X., Geisbrecht, B.V., Ghirlando, R., Beachy, P.A., Leahy, D.J.. Proc. Natl. Acad. Sci. U.S.A.. 2006: 103 17208-17213
• The ihog cell-surface proteins bind Hedgehog and mediate pathway activation Yao, S., Lum, L., Beachy, P.A.. Cell. 2006: 125 343-357
• Defective cerebellar response to mitogenic Hedgehog signaling in Down syndrome mice. Roper, R.J., Baxter, L.L., Saran, N.G., Klinedinst, D.K., Beachy, P.A., Reeves, R.H.. Proc. Natl. Acad. Sci. U.S.A.. 2006: 103 1452-1456