Publications
-
Tail wags dog: primary cilia and tumorigenesis.
Barakat MT,
Scott MP.
Cancer Cell.
2009;
16
(4):
276-7
-
Manipulation of an innate escape response in Drosophila: photoexcitation of acj6 neurons induces the escape response.
Zimmermann G,
Wang LP, Vaughan AG, Manoli DS, Zhang F, Deisseroth K, Baker BS, Scott MP.
PLoS One.
2009;
4
(4):
e5100
-
Rab35 controls actin bundling by recruiting fascin as an effector protein.
Zhang J,
Fonovic M, Suyama K, Bogyo M, Scott MP.
Science.
2009;
325
(5945):
1250-4
-
Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process.
Rohatgi R,
Milenkovic L, Corcoran RB, Scott MP.
Proc Natl Acad Sci U S A.
2009;
106
(9):
3196-201
-
A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size.
Kaplan DD,
Zimmermann G, Suyama K, Meyer T, Scott MP.
Genes Dev.
2008;
22
(14):
1877-93
-
Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice.
Corcoran RB,
Bachar Raveh T, Barakat MT, Lee EY, Scott MP.
Cancer Res.
2008;
68
(21):
8788-95
-
Cell biology. Arrestin' movement in cilia.
Rohatgi R,
Scott MP.
Science.
2008;
320
(5884):
1726-7
-
Drosophila Niemann-Pick type C-2 genes control sterol homeostasis and steroid biosynthesis: a model of human neurodegenerative disease.
Huang X,
Warren JT, Buchanan J, Gilbert LI, Scott MP.
Development.
2007;
134
(20):
3733-42
-
Developmental genomics of the most dangerous animal.
Scott MP,
Proc Natl Acad Sci U S A.
2007;
104
(29):
11865-6
-
Patched1 regulates hedgehog signaling at the primary cilium.
Rohatgi R,
Milenkovic L, Scott MP.
Science.
2007;
317
(5836):
372-6
-
Thirty-one flavors of Drosophila rab proteins.
Zhang J,
Schulze KL, Hiesinger PR, Suyama K, Wang S, Fish M, Acar M, Hoskins RA, Bellen HJ, Scott MP.
Genetics.
2007;
176
(2):
1307-22
-
Patching the gaps in Hedgehog signalling.
Rohatgi R,
Scott MP.
Nat Cell Biol.
2007;
9
(9):
1005-9
-
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells.
Corcoran RB,
Scott MP.
Proc Natl Acad Sci U S A.
2006;
103
(22):
8408-13
-
Mes2, a MADF-containing transcription factor essential for Drosophila development.
Zimmermann G,
Furlong EE, Suyama K, Scott MP.
Dev Dyn.
2006;
235
(12):
3387-95
-
Automated MEMS-based Drosophila embryo injection system for high-throughput RNAi screens.
Zappe S,
Fish M, Scott MP, Solgaard O.
Lab Chip.
2006;
6
(8):
1012-9
-
Cell-autonomous death of cerebellar purkinje neurons with autophagy in Niemann-Pick type C disease.
Ko DC,
Milenkovic L, Beier SM, Manuel H, Buchanan J, Scott MP.
PLoS Genet.
2005;
1
(1):
81-95
-
Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused.
Ho KS,
Suyama K, Fish M, Scott MP.
Development.
2005;
132
(6):
1401-12
-
A Drosophila model of the Niemann-Pick type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasis.
Huang X,
Suyama K, Buchanan J, Zhu AJ, Scott MP.
Development.
2005;
132
(22):
5115-24
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Obituary: Edward B. Lewis (1918-2004).
Scott MP,
Lawrence PA.
Nature.
2004;
431
(7005):
143
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Drosophila Costal1 mutations are alleles of protein kinase A that modulate hedgehog signaling.
Collier LS,
Suyama K, Anderson JH, Scott MP.
Genetics.
2004;
167
(2):
783-96
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A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo.
Wang QT,
Piotrowska K, Ciemerych MA, Milenkovic L, Scott MP, Davis RW, Zernicka-Goetz M.
Dev Cell.
2004;
6
(1):
133-44
-
Incredible journey: how do developmental signals travel through tissue?
Zhu AJ,
Scott MP.
Genes Dev.
2004;
18
(24):
2985-97
-
Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction.
Zhu AJ,
Zheng L, Suyama K, Scott MP.
Genes Dev.
2003;
17
(10):
1240-52
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The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels.
Ko DC,
Binkley J, Sidow A, Scott MP.
Proc Natl Acad Sci U S A.
2003;
100
(5):
2518-25
-
Sonic hedgehog in the nervous system: functions, modifications and mechanisms.
Ho KS,
Scott MP.
Curr Opin Neurobiol.
2002;
12
(1):
57-63
-
Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle.
Rousset R,
Wharton KA, Zimmermann G, Scott MP.
J Biol Chem.
2002;
277
(50):
49019-26
-
Gene expression during the life cycle of Drosophila melanogaster.
Arbeitman MN,
Furlong EE, Imam F, Johnson E, Null BH, Baker BS, Krasnow MA, Scott MP, Davis RW, White KP.
Science.
2002;
297
(5590):
2270-5
-
Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling.
Tree DR,
Shulman JM, Rousset R, Scott MP, Gubb D, Axelrod JD.
Cell.
2002;
109
(3):
371-81
-
Dynamics of the NPC1 protein in the organelles of living cells
M.P. Scott,
Ko, D.C., M.D. Gordon, J.S. Jin,.
Molec. Biol. Cell.
2001:
12
601-614.
-
Automated sorting of live transgenic embryos.
Furlong EE,
Profitt D, Scott MP.
Nat Biotechnol.
2001;
19
(2):
153-6
-
Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events.
Ko DC,
Gordon MD, Jin JY, Scott MP.
Mol Biol Cell.
2001;
12
(3):
601-14
-
Naked cuticle targets dishevelled to antagonize Wnt signal transduction.
Rousset R,
Mack JA, Wharton KA, Axelrod JD, Cadigan KM, Fish MP, Nusse R, Scott MP.
Genes Dev.
2001;
15
(6):
658-71
-
The developmental biology of brain tumors.
Wechsler-Reya R,
Scott MP.
Annu Rev Neurosci.
2001:
24
385-428
-
Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling.
Wharton KA,
Zimmermann G, Rousset R, Scott MP.
Dev Biol.
2001;
234
(1):
93-106
-
A mouse model for medulloblastoma and basal cell nevus syndrome.
Corcoran RB,
Scott MP.
J Neurooncol.
2001;
53
(3):
307-18
-
Jelly belly: a Drosophila LDL receptor repeat-containing signal required for mesoderm migration and differentiation.
Weiss JB,
Suyama KL, Lee HH, Scott MP.
Cell.
2001;
107
(3):
387-98
-
Patterns of gene expression during Drosophila mesoderm development.
Furlong EE,
Andersen EC, Null B, White KP, Scott MP.
Science.
2001;
293
(5535):
1629-33
-
Signalling and endocytosis: Wnt breaks down on back roads.
Scott M,
Nat Cell Biol.
2001;
3
(8):
E185-6
-
naked cuticle encodes an inducible antagonist of Wnt signalling.
Zeng W,
Wharton KA, Mack JA, Wang K, Gadbaw M, Suyama K, Klein PS, Scott MP.
Nature.
2000;
403
(6771):
789-95
-
Development: the natural history of genes.
Scott MP,
Cell.
2000;
100
(1):
27-40
-
Overexpression of ptc1 inhibits induction of Shh target genes and prevents normal patterning in the neural tube.
Goodrich LV,
Jung D, Higgins KM, Scott MP.
Dev Biol.
1999;
211
(2):
323-34
-
A putative Drosophila homolog of the Huntington's disease gene.
Li Z,
Karlovich CA, Fish MP, Scott MP, Myers RM.
Hum Mol Genet.
1999;
8
(9):
1807-15
-
Mouse patched1 controls body size determination and limb patterning.
Milenkovic L,
Goodrich LV, Higgins KM, Scott MP.
Development.
1999;
126
(20):
4431-40
-
Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog.
Wechsler-Reya RJ,
Scott MP.
Neuron.
1999;
22
(1):
103-14
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Splitting hairs: dissecting roles of signaling systems in epidermal development.
Oro AE,
Scott MP.
Cell.
1998;
95
(5):
575-8
-
Hedgehog and patched in neural development and disease.
Goodrich LV,
Scott MP.
Neuron.
1998;
21
(6):
1243-57
-
Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity.
Weiss JB,
Von Ohlen T, Mellerick DM, Dressler G, Doe CQ, Scott MP.
Genes Dev.
1998;
12
(22):
3591-602
-
Wnt and TGFbeta signals subdivide the AbdA Hox domain during Drosophila mesoderm patterning.
Bilder D,
Graba Y, Scott MP.
Development.
1998;
125
(9):
1781-90
-
New players and puzzles in the Hedgehog signaling pathway.
Johnson RL,
Scott MP.
Curr Opin Genet Dev.
1998;
8
(4):
450-6
-
Hedgehog and wingless induce metameric pattern in the Drosophila visceral mesoderm.
Bilder D,
Scott MP.
Dev Biol.
1998;
201
(1):
43-56
-
Progressive ataxia, myoclonic epilepsy and cerebellar apoptosis in cystatin B-deficient mice.
Pennacchio LA,
Bouley DM, Higgins KM, Scott MP, Noebels JL, Myers RM.
Nat Genet.
1998;
20
(3):
251-8
-
Altered neural cell fates and medulloblastoma in mouse patched mutants.
Goodrich LV,
Milenkovi? L, Higgins KM, Scott MP.
Science.
1997;
277
(5329):
1109-13
-
Control of cell growth and fate by patched genes.
Johnson RL,
Scott MP.
Cold Spring Harb Symp Quant Biol.
1997:
62
205-15
-
Summary: a common language.
Scott MP,
Cold Spring Harb Symp Quant Biol.
1997:
62
555-62
-
Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway.
Sisson JC,
Ho KS, Suyama K, Scott MP.
Cell.
1997;
90
(2):
235-45
-
Basal cell carcinomas in mice overexpressing sonic hedgehog.
Oro AE,
Higgins KM, Hu Z, Bonifas JM, Epstein EH, Scott MP.
Science.
1997;
276
(5313):
817-21
-
Human homolog of patched, a candidate gene for the basal cell nevus syndrome.
Johnson RL,
Rothman AL, Xie J, Goodrich LV, Bare JW, Bonifas JM, Quinn AG, Myers RM, Cox DR, Epstein EH, Scott MP.
Science.
1996;
272
(5268):
1668-71
-
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.
Goodrich LV,
Johnson RL, Milenkovic L, McMahon JA, Scott MP.
Genes Dev.
1996;
10
(3):
301-12
-
Homeotic response elements are tightly linked to tissue-specific elements in a transcriptional enhancer of the teashirt gene.
McCormick A,
Coré N, Kerridge S, Scott MP.
Development.
1995;
121
(9):
2799-812
-
Genomic regions required for morphogenesis of the Drosophila embryonic midgut.
Bilder D,
Scott MP.
Genetics.
1995;
141
(3):
1087-100
-
patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets.
Johnson RL,
Grenier JK, Scott MP.
Development.
1995;
121
(12):
4161-70
-
The Drosophila snr1 and brm proteins are related to yeast SWI/SNF proteins and are components of a large protein complex.
Dingwall AK,
Beek SJ, McCallum CM, Tamkun JW, Kalpana GV, Goff SP, Scott MP.
Mol Biol Cell.
1995;
6
(7):
777-91
-
Intimations of a creature.
Scott MP,
Cell.
1994;
79
(7):
1121-4
-
Regulation of a decapentaplegic midgut enhancer by homeotic proteins.
Manak JR,
Mathies LD, Scott MP.
Development.
1994;
120
(12):
3605-19
-
Role of the teashirt gene in Drosophila midgut morphogenesis: secreted proteins mediate the action of homeotic genes.
Mathies LD,
Kerridge S, Scott MP.
Development.
1994;
120
(10):
2799-809
-
patched overexpression causes loss of wingless expression in Drosophila embryos.
Schuske K,
Hooper JE, Scott MP.
Dev Biol.
1994;
164
(1):
300-11
-
Setting limits on homeotic gene function: restraint of Sex combs reduced activity by teashirt and other homeotic genes.
Andrew DJ,
Horner MA, Petitt MG, Smolik SM, Scott MP.
EMBO J.
1994;
13
(5):
1132-44
-
A class act: conservation of homeodomain protein functions.
Manak JR,
Scott MP.
Dev Suppl.
1994:
61-77
-
A rational nomenclature for vertebrate homeobox (HOX) genes.
Scott MP,
Nucleic Acids Res.
1993;
21
(8):
1687-8
-
Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity.
Zeng W,
Andrew DJ, Mathies LD, Horner MA, Scott MP.
Development.
1993;
118
(2):
339-52
-
Gene regulation: able assistants for homeodomain proteins.
Robert Manak J,
Scott MP.
Curr Biol.
1993;
3
(5):
318-20
-
Downstream of the homeotic genes.
Andrew DJ,
Scott MP.
New Biol.
1992;
4
(1):
5-15
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