Tony Wyss-Coray

Honors and Awards

• Senior Research Career Scientist, Veterans Administration (2012)
• Zenith Award, Alzheimer's Association (2005)
• Distinguished Scholar Award, The John Douglas French Alzheimer’s Foundation (2005)
• Editor, Journal of Neuroinflammation (2004)
• Medical and Scientific Advisory Council, Alzheimer's Association of Northern California & Northern Nevada (2004)

Professional Education

Postdoctoral Advisees

Joseph Castellano,  Eva Czirr,  Yingbo He,  Kurt Lucin,  Vidhu Mathur,  Jinte Middeldorp,  Saul Villeda

Graduate & Fellowship Program Affiliations

• Immunology
• Neurosciences

Internet Links

• Lab Website

Current Research Interests

Our laboratory studies the role of immune and injury responses in neurodegeneration and Alzheimer’s disease. We seek to understand how immune responses and injury pathways may modulate neurodegeneration and age-related changes in the brain. We study these pathways in vivo and in cell culture using a number of genetic and proteomic tools. We have been particularly interested in the TGF-beta signaling pathway as a major regulator of biological processes and we are developing genetic and pharmacological agents to manipulate this pathway.

Publications

• The immunology of neurodegeneration. Czirr E, Wyss-Coray T. J Clin Invest. 2012; 122 (4): 1156-63
• Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis. Moriyama M, Fukuhara T, Britschgi M, He Y, Narasimhan R, Villeda S, Molina H, Huber BT, Holers M, Wyss-Coray T. J Neurosci. 2011; 31 (11): 3981-9
• Modeling of pathological traits in Alzheimer's disease based on systemic extracellular signaling proteome. Britschgi M, Rufibach K, Huang SL, Clark CM, Kaye JA, Li G, Peskind ER, Quinn JF, Galasko DR, Wyss-Coray T. Mol Cell Proteomics. 2011; 10 (10): M111.008862
• The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Després S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T. Nature. 2011; 477 (7362): 90-4
• Regulation of amyloid precursor protein processing by the Beclin 1 complex. Jaeger PA, Pickford F, Sun CH, Lucin KM, Masliah E, Wyss-Coray T. PLoS One. 2010; 5 (6): e11102