Matthew Scott

Administrative Appointments

• Associate Chair, Developmental Biology (1999 - 2002)
• Chair, Developmental Biology (1996 - 1998)
• Co-Chair, Center for Children's Brain Tumors (2005 - present)
• Chair, Bio-X Program (2001 - 2007)

Professional Education

Postdoctoral Advisees

Jian Cao, Thomas Hartl, Andres Klein, Eunice Lee

Graduate & Fellowship Program Affiliations

• Cancer Biology
• Developmental Biology
• Genetics
• Neurosciences
• Bioengineering

Web Site Links

• Scott Lab Home Page

Industry Relationships

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Research Interests

Early embryonic development is governed by an exquisite interplay of genes that organizes cells as they proliferate. Signals flow between cells to control their fates; information inherited by the cells influences their responses to the signals. Transcription factors necessary for forming particular parts of the body—such as head-to-tail differences, heart, eyes, or nervous system—have remained dedicated to those tasks through evolution. Similarly, the genes and proteins that code for signals, signal receptors, and information transfer within the cell have been preserved. We study evolutionarily conserved regulators in flies and in mice to learn how the embryo is constructed and how pattern-organizing genetic programs arose, function, and change. Genetic damage to developmental regulators can lead to cancer, birth defects, and neurodegeneration; we study all of these processes in the mammalian cerebellum.

The Hedgehog Signaling System in Development and Cancer

The Hedgehog (Hh) signaling system is used in most animals to control the embryonic development of numerous tissues, such as brain and spinal cord, limbs, skeleton, and skin. We have asked three questions about Hh signaling: (1) Where does the signal go from and to? (2) What information does it carry? (3) How is the signal received, transduced, and interpreted? Mutations in human PATCHED (PTCH) cause birth defects and medulloblastoma of the cerebellum, the most common childhood malignant brain tumor, and basal cell carcinoma of the skin, the most common human cancer. We are using mutant ptc mouse models to investigate how normal cerebellum cells become tumor cells. We are studying detailed mechanisms of Hh signal transduction including sterol effects. We are also investigating genetic control of normal cerebellum development in mice and zebrafish.

Molecular of the Niemann-Pick type C syndrome, a neurodegenerative disorder

Publications

• Tail wags dog: primary cilia and tumorigenesis. Barakat MT, Scott MP. Cancer Cell. 2009; 16 (4): 276-7
• Manipulation of an innate escape response in Drosophila: photoexcitation of acj6 neurons induces the escape response. Zimmermann G, Wang LP, Vaughan AG, Manoli DS, Zhang F, Deisseroth K, Baker BS, Scott MP. PLoS One. 2009; 4 (4): e5100
• Rab35 controls actin bundling by recruiting fascin as an effector protein. Zhang J, Fonovic M, Suyama K, Bogyo M, Scott MP. Science. 2009; 325 (5945): 1250-4
• Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Rohatgi R, Milenkovic L, Corcoran RB, Scott MP. Proc Natl Acad Sci U S A. 2009; 106 (9): 3196-201
• A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. Kaplan DD, Zimmermann G, Suyama K, Meyer T, Scott MP. Genes Dev. 2008; 22 (14): 1877-93