Jared Churko

Publication Details

• Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant.

  Manias JL, Plante I, Gong XQ, Shao Q, Churko J, Bai D, Laird DW. Cardiovasc Res. 2008; 80 (3): 385-95

  More than 40 mutations in the GJA1 gene encoding connexin43 (Cx43) have been linked to oculodentodigital dysplasia (ODDD), a pleiotropic, autosomal dominant disorder. We hypothesized that even with a significant reduction in the levels of Cx43 in a mutant mouse model of ODDD (Gja1(Jrt/+)) harbouring a G60S mutation (Cx43(G60S)), cardiomyocyte function may only be moderately compromised given that a majority of mutant mice typically survive.

  PubMedID: 18678643