Amato J. Giaccia

Publication Details

• The roles of Chk 1 and Chk 2 in hypoxia and reoxygenation.

  Hammond EM, Freiberg RA, Giaccia AJ. Cancer Lett. 2006; 238 (2): 161-7

  Both Chk 1 and Chk 2 are critically important checkpoint kinases. Chk 1 is an essential gene that is required for normal cell division and Chk 2 has been found to be mutated in an ever-growing list of human malignancies. Our recent studies indicate that both Chk 1 and Chk 2 have roles to play in the physiological stress of hypoxia/reoxygenation. Loss or inhibition of either kinase sensitizes cells to hypoxia/reoxygenation indicating that either or both could represent significant therapeutic targets.

  PubMedID: 16085356