{"result":[{"lastName":"Ruoss","clinicalFocus":[{"focus":"Critical Care Medicine"},{"focus":"Pulmonary Disease"},{"focus":"Pulmonology (Lung) and Critical Care "}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Medicine - Pulmonary & Critical Care Med"}],"primaryAppointment":"Associate Professor - Med Center Line,Medicine - Pulmonary & Critical Care Med","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4241&type=small&showNoImage","displayName":"Stephen Ruoss","firstName":"Stephen","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Stephen_Ruoss","researchInterest":"We have an active collaborative project examining basic and clinical aspects of non-tuberculous mycobacterial lung infection in non-immune compromised adults. Studies have examined possible cellular immune mechanisms for increased susceptibility to these infections, and are also investigating aspects of optimal diagnosis and treatment. In addition, a clinical and translational research program is investigating the causes and genetic factors underlying the evolution of bronchiectasis."},{"lastName":"Crabtree","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4283&type=small&showNoImage","displayName":"Gerald Crabtree","firstName":"Gerald","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Gerald_Crabtree","researchInterest":"The role of chromatin in stem cell formation and function.  Development of small molecule regulators as experimental probes and therapeutic leads.  Signaling through calcineurin  and NFAT in vertebrate development."},{"lastName":"Rosen","clinicalFocus":[{"focus":"Pulmonary Disease"},{"focus":"Pulmonology (Lung) and Critical Care "}],"appointments":[{"appointment":"Associate Professor,Medicine - Pulmonary & Critical Care Med"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Medicine - Pulmonary & Critical Care Med","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4245&type=small&showNoImage","displayName":"Glenn Rosen","firstName":"Glenn","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Glenn_Rosen","researchInterest":"Our laboratory examines apoptotic and cell cycle pathways in cancer and lung disease. We have identified a novel cell cycle protein which regulates cell cycle progression in immune cells and the lung.  We are also studying signaling pathways that regulate cancer cell growth and metastasis."},{"lastName":"Nolan","clinicalFocus":[],"appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","displayName":"Garry Nolan","firstName":"Garry","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Garry_Nolan","researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function.  Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level."},{"lastName":"Pearl","clinicalFocus":[{"focus":"Anesthesia"},{"focus":"Critical Care Medicine"}],"appointments":[{"appointment":"Professor,Anesthesia"}],"primaryAppointment":"Professor,Anesthesia","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4680&type=small&showNoImage","displayName":"Ronald Pearl","firstName":"Ronald","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Ronald_Pearl","researchInterest":"Mechanims (molecular and cellular) of pulmonary hypertension, treatment of pulmonary hypertension, treatment of respiratory failure, treatment of septic shock, hemodynamic monitoring"},{"lastName":"Quertermous","clinicalFocus":[],"appointments":[{"appointment":"Professor,Medicine - Cardiovascular Medicine"}],"primaryAppointment":"Professor,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4426&type=small&showNoImage","displayName":"Thomas Quertermous, MD","firstName":"Thomas","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Thomas_Quertermous","researchInterest":"Understanding genetic basis of cardiovascular function and disease."},{"lastName":"Graef","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Pathology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7247&type=small&showNoImage","displayName":"Isabella Graef","firstName":"Isabella","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Isabella_Graef","researchInterest":"We are interested in addressing questions in neuronal development and function by a combination of genetic, cell biological, biochemical and chemical approaches. \r\nThe main focus of our lab is centered around two topics: 1) the interface of signaling and gene regulation in neuronal development, with a focus on calcineurin-NFAT signaling; 2) the development of small molecules, which interfere with protein-protein interactions underlying neurodegenerative diseases."},{"lastName":"Rabinovitch","clinicalFocus":[{"focus":"Cardiology (Heart), Pediatric"},{"focus":"Pediatric Cardiology"}],"appointments":[{"appointment":"Professor,Pediatrics - Cardiology"},{"appointment":"Professor (By courtesy),Developmental Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Pediatrics - Cardiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3897&type=small&showNoImage","displayName":"Marlene Rabinovitch","firstName":"Marlene","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Marlene_Rabinovitch","researchInterest":"Our research focuses on understanding the regulation of genes associated with cardiovascular development and disease, through the use of cultured cells and tissues and genetically modified mouse models.   A variety of different aberrant pathways are being characterized, including those related to signaling through the bone morphogenetic proteins, serotonin and the S100 family of calcium binding proteins, and those defining how a microtubule associated protein regulates mRNA translation."},{"lastName":"Gardner","clinicalFocus":[{"focus":"Clinical Pharmacology"}],"appointments":[{"appointment":"Professor,Medicine - Clinical Pharmacology"}],"primaryAppointment":"Professor,Medicine - Clinical Pharmacology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4500&type=small&showNoImage","displayName":"Phyllis Gardner","firstName":"Phyllis","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Phyllis_Gardner","researchInterest":"Ion channels and signal transduction;  patch clamp and fluorometric analysis; cell and molecular biology; cystic fibrosis gene therapy."},{"lastName":"Berry","clinicalFocus":[{"focus":"Pathology and Laboratory Medicine"},{"focus":"Anatomic/Clinical Pathology"}],"appointments":[{"appointment":"Professor - Med Center Line,Pathology"}],"primaryAppointment":"Professor - Med Center Line,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4091&type=small&showNoImage","displayName":"Gerald Berry","firstName":"Gerald","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Gerald_Berry","researchInterest":"Cardiopulmonary and pulmonary transplant medicine; diagnostic surgical pathology"},{"lastName":"Utz","clinicalFocus":[{"focus":"Immunology and Rheumatology"},{"focus":"Rheumatology"}],"appointments":[{"appointment":"Associate Professor,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor,Medicine - Immunology & Rheumatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4001&type=small&showNoImage","displayName":"Paul Utz","firstName":"Paul","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Paul_Utz","researchInterest":"The long-term research goal of Dr. Utz\u0092s laboratory is (1) to develop a better understanding of the pathogenic mechanisms underlying systemic lupus erythematosus (SLE) and other autoimmune diseases by exploring signaling pathways that are activated during apoptosis; and (2) to better understand the complicated process of programmed cell death."},{"lastName":"Alastalo","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Pediatrics"}],"primaryAppointment":"Postdoctoral Research fellow, Pediatrics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9610&type=small&showNoImage","displayName":"Tero-Pekka Alastalo","firstName":"Tero-Pekka","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Tero-Pekka_Alastalo","researchInterest":""},{"lastName":"de Jesus Perez","clinicalFocus":[{"focus":"Pulmonary Disease"},{"focus":"Pulmonary Hypertension"}],"appointments":[{"appointment":"Instructor,Medicine - Pulmonary & Critical Care Med"}],"primaryAppointment":"Instructor,Medicine - Pulmonary & Critical Care Med","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7827&type=small&showNoImage","displayName":"Vinicio de Jesus Perez MD","firstName":"Vinicio","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Vinicio_de Jesus Perez","researchInterest":"My work is aimed at understanding the molecular mechanisms involved in the development and progression of pulmonary arterial hypertension (PAH).   I am interested in understanding the role that the BMP  and Wnt pathways play in regulating functions of pulmonary endothelial and smooth muscle cells both in health and disease."},{"lastName":"Chu","clinicalFocus":[{"focus":"Oncology"}],"appointments":[{"appointment":"Professor,Medicine - Oncology"},{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4149&type=small&showNoImage","displayName":"Gilbert Chu","firstName":"Gilbert","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Gilbert_Chu","researchInterest":"Our laboratory focuses on understanding how cells respond to DNA damage. Our research currently involves areas that interact with each other: repair of radiation damage, and transcriptional responses to DNA damage."},{"lastName":"Brown","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4284&type=small&showNoImage","displayName":"Patrick O. Brown","firstName":"Patrick","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Patrick_Brown","researchInterest":"Dr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program.  The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer."},{"lastName":"Alvira","clinicalFocus":[{"focus":"Intensive Care, Pediatric"},{"focus":"Pediatric Critical Care Medicine"}],"appointments":[{"appointment":"Instructor,Pediatrics - Intensive Care"}],"primaryAppointment":"Instructor,Pediatrics - Intensive Care","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6787&type=small&showNoImage","displayName":"Cristina M. Alvira","firstName":"Cristina","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Cristina_Alvira","researchInterest":""},{"lastName":"Chang","clinicalFocus":[{"focus":"Dermatology"}],"appointments":[{"appointment":"Associate Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Dermatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6089&type=small&showNoImage","displayName":"Howard Y. Chang","firstName":"Howard","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Howard_Chang","researchInterest":"The Chang group is focused on two fundamental questions in epithelial biology: (1) the basis of positional identities in epidermal structures throughout the body, and (2) how those signals and boundaries may be abrogated to allow cancer metastasis. We are investigating the roles of site-specific fibroblast differentiation in patterning the epidermis, and dissecting the mechanisms of wound healing programs in cancer metastasis."},{"lastName":"Sarnow","clinicalFocus":[],"appointments":[{"appointment":"Professor,Microbiology & Immunology"}],"primaryAppointment":"Professor,Microbiology & Immunology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4458&type=small&showNoImage","displayName":"Peter Sarnow","firstName":"Peter","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Peter_Sarnow","researchInterest":"Our laboratory studies virus-host interactions with an emphasis microRNA-mediated gene regulation and on translational control. The mechanism by which a liver-specific microRNA regulates hepatitis C virus genome replication is under intense scrutiny. In addition, the mechanism of internal ribosome entry in certain cellular and viral mRNAs and its biological role in growth and development is being investigated."},{"lastName":"Boxer","clinicalFocus":[{"focus":"Hematology"},{"focus":"Multiple Myeloma"},{"focus":"Multiple Myeloma - Medical Oncology"},{"focus":"Plasmacytoma"},{"focus":"Plasmacytoma - Hematology"},{"focus":"Plasmacytoma - Medical Oncology"}],"appointments":[{"appointment":"Professor,Medicine - Hematology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Medicine - Hematology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4658&type=small&showNoImage","displayName":"Linda Boxer","firstName":"Linda","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Linda_Boxer","researchInterest":"Regulation of expression of oncogenes in normal and malignant hematologic cells."},{"lastName":"Giaccia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Professor (By courtesy),Obstetrics & Gynecology"},{"appointment":"Professor (By courtesy),Surgery"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4141&type=small&showNoImage","displayName":"Amato Giaccia","firstName":"Amato","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Amato_Giaccia","researchInterest":"Cellular response to hypoxia and ionizing radiation; cell-cycle control, apoptosis and angiogenesis in transformed cells."},{"lastName":"Stankunas","clinicalFocus":[],"appointments":[{"appointment":"Instructor,Medicine - Cardiovascular Medicine"}],"primaryAppointment":"Instructor,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9759&type=small&showNoImage","displayName":"Kryn Stankunas","firstName":"Kryn","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Kryn_Stankunas","researchInterest":""},{"lastName":"Brunet","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6012&type=small&showNoImage","displayName":"Anne Brunet","firstName":"Anne","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Anne_Brunet","researchInterest":"Our lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri."},{"lastName":"Dolmetsch","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Neurobiology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Neurobiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4040&type=small&showNoImage","displayName":"Ricardo Dolmetsch","firstName":"Ricardo","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Ricardo_Dolmetsch","researchInterest":"Our lab studies the underlying neurobiology of autism and other neuro-developmental disorders.  We are particularly interested in understanding how electrical activity and calcium signals control the development of the brain and how this is altered in children with autism spectrum disorders. We are also developing new tools to study and repair the developing brain."},{"lastName":"Lewis","clinicalFocus":[{"focus":"Infectious Diseases, Pediatric"},{"focus":"Pediatric Infectious Disease"}],"appointments":[{"appointment":"Professor - Med Center Line,Pediatrics - Immunology & Transplant Biology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor - Med Center Line,Pediatrics - Immunology & Transplant Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4439&type=small&showNoImage","displayName":"David B. Lewis","firstName":"David","href":"http://med.stanford.edu/profiles/pulmonary/researcher/David_Lewis","researchInterest":"My laboratory has two major research interests.  First, to define cellular and molecular mechanisms that limit T cell responses to vaccines and pathogens during normal early postnatal development and in cases of inherited genetic immunodeficiencies.  Second, to determine how these limitations in immunity can be overcome by using novel approaches for vaccine adjuvants, with a particular focus on anti-viral vaccines."},{"lastName":"Upadhyay","clinicalFocus":[{"focus":"Lung Cancer, Solitary Pulmonary Nodule"},{"focus":"Asthma, Adult"},{"focus":"Pulmonology (Lung) and Critical Care "},{"focus":"Pulmonary Medicine"}],"appointments":[{"appointment":"Assistant Professor - Med Center Line,Medicine - Pulmonary & Critical Care Med"}],"primaryAppointment":"Assistant Professor - Med Center Line,Medicine - Pulmonary & Critical Care Med","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6147&type=small&showNoImage","displayName":"Daya Upadhyay","firstName":"Daya","href":"http://med.stanford.edu/profiles/pulmonary/researcher/Daya_Upadhyay","researchInterest":"Dr. Upadhyay examines the molecular link between \u0091Airway Inflammation and Lung Cancer\u0092. We study nicotine stimulation-induced genes that cause escape from oxidative stress mediated Lung Senescence and development of lung cancer and cancer stem cells, and utilizes microRNA analysis for early diagnose of lung cancer in COPD/ smokers. By using exhaled breath condensates and human airway tissue, we examine the genes regulating airway inflammation in a complex duo of \u0091Asthma and obesity\u0092."}]}