Edda Spiekerkoetter

Publications

• Loss of adenomatous poliposis coli-α3 integrin interaction promotes endothelial apoptosis in mice and humans. de Jesus Perez VA, Yuan K, Orcholski ME, Sawada H, Zhao M, Li CG, Tojais NF, Nickel N, Rajagopalan V, Spiekerkoetter E, Wang L, Dutta R, Bernstein D, Rabinovitch M. Circ Res. 2012; 111 (12): 1551-64
• Safety and efficacy of transition from systemic prostanoids to inhaled treprostinil in pulmonary arterial hypertension. de Jesus Perez VA, Rosenzweig E, Rubin LJ, Poch D, Bajwa A, Park M, Jain M, Bourge RC, Kudelko K, Spiekerkoetter E, Liu J, Hsi A, Zamanian RT. Am J Cardiol. 2012; 110 (10): 1546-50
• BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways. Perez VA, Ali Z, Alastalo TP, Ikeno F, Sawada H, Lai YJ, Kleisli T, Spiekerkoetter E, Qu X, Rubinos LH, Ashley E, Amieva M, Dedhar S, Rabinovitch M. J Cell Biol. 2011; 192 (1): 171-88
• Neutrophil elastase is produced by pulmonary artery smooth muscle cells and is linked to neointimal lesions. Kim YM, Haghighat L, Spiekerkoetter E, Sawada H, Alvira CM, Wang L, Acharya S, Rodriguez-Colon G, Orton A, Zhao M, Rabinovitch M. Am J Pathol. 2011; 179 (3): 1560-72
• S100A4 and bone morphogenetic protein-2 codependently induce vascular smooth muscle cell migration via phospho-extracellular signal-regulated kinase and chloride intracellular channel 4. Spiekerkoetter E, Guignabert C, de Jesus Perez V, Alastalo TP, Powers JM, Wang L, Lawrie A, Ambartsumian N, Schmidt AM, Berryman M, Ashley RH, Rabinovitch M. Circ Res. 2009; 105 (7): 639-47, 13 p following 647
• Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin. Spiekerkoetter E, Alvira CM, Kim YM, Bruneau A, Pricola KL, Wang L, Ambartsumian N, Rabinovitch M. Am J Physiol Lung Cell Mol Physiol. 2008; 294 (2): L276-89
• Experience with inhaled iloprost and bosentan in portopulmonary hypertension. Hoeper MM, Seyfarth HJ, Hoeffken G, Wirtz H, Spiekerkoetter E, Pletz MW, Welte T, Halank M. Eur Respir J. 2007; 30 (6): 1096-102
• Goal-oriented treatment and combination therapy for pulmonary arterial hypertension. Hoeper MM, Markevych I, Spiekerkoetter E, Welte T, Niedermeyer J. Eur Respir J. 2005; 26 (5): 858-63
• Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension. Merklinger SL, Wagner RA, Spiekerkoetter E, Hinek A, Knutsen RH, Kabir MG, Desai K, Hacker S, Wang L, Cann GM, Ambartsumian NS, Lukanidin E, Bernstein D, Husain M, Mecham RP, Starcher B, Yanagisawa H, Rabinovitch M. Circ Res. 2005; 97 (6): 596-604
• Interdependent serotonin transporter and receptor pathways regulate S100A4/Mts1, a gene associated with pulmonary vascular disease. Lawrie A, Spiekerkoetter E, Martinez EC, Ambartsumian N, Sheward WJ, MacLean MR, Harmar AJ, Schmidt AM, Lukanidin E, Rabinovitch M. Circ Res. 2005; 97 (3): 227-35
• Mts1/S100A4 stimulates human pulmonary artery smooth muscle cell migration through multiple signaling pathways. Spiekerkoetter E, Lawrie A, Merklinger S, Ambartsumian N, Lukanidin E, Schmidt AM, Rabinovitch M. Chest. 2005; 128 (6 Suppl): 577S
• Bosentan treatment in patients with primary pulmonary hypertension receiving nonparenteral prostanoids. Hoeper MM, Taha N, Bekjarova A, Gatzke R, Spiekerkoetter E. Eur Respir J. 2003; 22 (2): 330-4
• Effects of inhaled salbutamol in primary pulmonary hypertension. Spiekerkoetter E, Fabel H, Hoeper MM. Eur Respir J. 2002; 20 (3): 524-8
• Intravenous iloprost for treatment failure of aerosolised iloprost in pulmonary arterial hypertension. Hoeper MM, Spiekerkoetter E, Westerkamp V, Gatzke R, Fabel H. Eur Respir J. 2002; 20 (2): 339-43
• [Long-term treatment of primary pulmonary hypertension with inhaled iloprost]. Hoeper MM, Schwarze M, Ehlerding S, Adler-Schuermeyer A, Spiekerkoetter E, Niedermeyer J, Hamm M, Fabel H. Pneumologie. 2001; 55 (1): 38-43
• Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue. Hoeper MM, Schwarze M, Ehlerding S, Adler-Schuermeyer A, Spiekerkoetter E, Niedermeyer J, Hamm M, Fabel H. N Engl J Med. 2000; 342 (25): 1866-70
• Prevalence of malignancies after lung transplantation. Spiekerkoetter E, Krug N, Hoeper M, Wiebe K, Hamm M, Harringer W, Haverich A, Fabel H. Transplant Proc. 1998; 30 (4): 1523-4