Jerome Yesavage

Publication Details

• Ethanol pharmacokinetics in white women: nonlinear model fitting versus zero-order elimination analyses.

  Mumenthaler MS, Taylor JL, Yesavage JA. Alcohol Clin Exp Res. 2000; 24 (9): 1353-62

  Studies have shown repeatedly that ethanol pharmacokinetics are not linear, yet most researchers still determine ethanol elimination by linear, zero-order kinetics. The goals of the present work were to: (1) fit four nonlinear pharmacokinetic models to mean breath alcohol concentration (BrAC)-time data of 27 women and determine the best-fit model; (2) fit the determined best-fit model to individual BrAC data and estimate the pharmacokinetic parameters; and (3) compare the method of nonlinear model fitting with the classical zero-order elimination method and determine in which cases the classical approach is justified.

  PubMedID: 11003200