Jamie Zeitzer

Publication Details

• Lesions of the suprachiasmatic nucleus eliminate the daily rhythm of hypocretin-1 release.

  Zhang S, Zeitzer JM, Yoshida Y, Wisor JP, Nishino S, Edgar DM, Mignot E. Sleep. 2004; 27 (4): 619-27

  Hypocretins (orexins) are involved in the sleep disorder narcolepsy. While hypocretin-1 has a daily oscillation, little is known regarding the relative contribution of circadian and homeostatic components on hypocretin release. The effect of lesions of the suprachiasmatic nucleus (SCN) on hypocretin-1 in the cerebrospinal fluid (CSF) was examined.

  PubMedID: 15282996