Keith Humphreys

Publication Details

• Determining effective methadone doses for individual opioid-dependent patients.

  Trafton JA, Minkel J, Humphreys K. PLoS Med. 2006; 3 (3): e80

  Randomized clinical trials of methadone maintenance have found that on average high daily doses are more effective for reducing heroin use, and clinical practice guidelines recommend 60 mg/d as a minimum dosage. Nevertheless, many clinicians report that some patients can be stably maintained on lower methadone dosages to optimal effect, and clinic dosing practices vary substantially. Studies of individual responses to methadone treatment may be more easily translated into clinical practice.

  PubMedID: 16448216