Christian Guilleminault

Publication Details

• Baclofen trial in six myotonic dystrophy patients.

  Guilleminault C, Flagg WH, Coburn SC, Dement WC. Acta Neurol Scand. 1978; 57 (3): 232-8

  Six young adult patients with grade I myotonic dystrophy and a complaint of daytime somnolence underwent 36-hour polygraphic monitoring, dynamometric and electromyographic studies before and under baclofen (60 mg/daily). Patients with the most severe daytime sleepiness had pathologic Sleep Apnea Indexes. After 6 weeks' ingestion of baclofen, no subjective or objective effect on patient symptomatology was found.

  PubMedID: 352086