Trisha Suppes, MD, PhD

Publication Details

• Valproate is associated with new-onset oligoamenorrhea with hyperandrogenism in women with bipolar disorder.

  Joffe H, Cohen LS, Suppes T, McLaughlin WL, Lavori P, Adams JM, Hwang CH, Hall JE, Sachs GS. Biol Psychiatry. 2006; 59 (11): 1078-86

  Preliminary evidence suggests that valproate is associated with isolated features of polycystic ovarian syndrome (PCOS), while contradictory data support an association between epilepsy and PCOS. The development of PCOS features after initiation of valproate was therefore examined in women with bipolar disorder using a standardized definition of PCOS.

  PubMedID: 16448626