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Lawrence Steinman Info

Lawrence Steinman

Email:
Profile: http://med.stanford.edu/profiles/Lawrence_Steinman/
Academic Appointments
Appointment
Organization
Professor
Neurology & Neurological Sciences
Professor
Pediatrics
Professor (By courtesy)
Genetics
Graduate & Fellowship Program Affiliations
Immunology ; Neurosciences ;
 
Honors & Awards
Title
Organization
Date(s)
Friedrich Sasse Prize
Free Univ.of Berlin
1994
Sen. Jacob Javits Award
US Congress
1988-2002
John M. Dystel Prize
American Academy of Neurology and National MS Society
2004
Administrative Appointments
Title
Organization
Start Year
End Year
Chairman, Interdepartmental Program in Immunology
Interdepartmental Program in Immunology, Stanford University
2002
2005
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
MD
Harvard University
Neurochemistry
1973
Research Interests

Our laboratory is dedicated to understanding the pathogenesis of autoimmune diseases, particularly multiple sclerosis. We have developed several new therapies for autoimmunity, including some in Phase 2 clinical trials, as well as one approved drug, natalizumab. We have developed microarray technology for detecting autoantibodies to myelin proteins and lipids. We employ a diverse range of molecular and celluar approaches to trying to understand multiple sclerosis.

Publications
  • Dunn SE, Ousman SS, Sobel RA, Zuniga L, Baranzini SE, Youssef S, Crowell A, Loh J, Oksenberg J, Steinman L "Peroxisome proliferator-activated receptor (PPAR){alpha} expression in T cells mediates gender differences in development of T cell-mediated autoimmunity." J Exp Med 2007; More »
  • Steinman L, "A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage." Nat Med 2007; 13: 2: 139-45 More »
  • Ousman SS, Tomooka BH, van Noort JM, Wawrousek EF, O'Conner K, Hafler DA, Sobel RA, Robinson WH, Steinman L "Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination." Nature 2007; 448: 7152: 474-9 More »
  • Kanter JL, Narayana S, Ho PP, Catz I, Warren KG, Sobel RA, Steinman L, Robinson WH "Lipid microarrays identify key mediators of autoimmune brain inflammation." Nat Med 2006; 12: 1: 138-143 More »
  • Dunn SE, Youssef S, Goldstein MJ, Prod'homme T, Weber MS, Zamvil SS, Steinman L "Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin." J Exp Med 2006; 203: 2: 401-12 More »
187 publications:   view full list