Publications
-
A Tip leads cytotoxic T cells to the crime scene in neuroinflammation.
Steinman L,
Nat Immunol.
2013;
14
(3):
196-7
-
A writing-intensive course improves biology undergraduates' perception and confidence of their abilities to read scientific literature and communicate science.
Brownell SE,
Price JV, Steinman L.
Adv Physiol Educ.
2013;
37
(1):
70-9
-
Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.
Kurnellas MP,
Adams CM, Sobel RA, Steinman L, Rothbard JB.
Sci Transl Med.
2013;
5
(179):
179ra42
-
Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain.
Rafalski VA,
Ho PP, Brett JO, Ucar D, Dugas JC, Pollina EA, Chow LM, Ibrahim A, Baker SJ, Barres BA, Steinman L, Brunet A.
Nat Cell Biol.
2013
-
Inflammatory cytokines at the summits of pathological signal cascades in brain diseases.
Steinman L,
Sci Signal.
2013;
6
(258):
pe3
-
Piet Mondrian's trees and the evolution in understanding multiple sclerosis, Charcot Prize Lecture 2011.
Steinman L,
Axtell RC, Barbieri D, Bhat R, Brownell SE, de Jong BA, Dunn SE, Grant JL, Han MH, Ho PP, Kuipers HF, Kurnellas MP, Ousman SS, Rothbard JB.
Mult Scler.
2013;
19
(1):
5-14
-
Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing- remitting multiple sclerosis.
Van Haren K,
Tomooka BH, Kidd BA, Banwell B, Bar-Or A, Chitnis T, Tenembaum SN, Pohl D, Rostasy K, Dale RC, O'Connor KC, Hafler DA, Steinman L, Robinson WH.
Mult Scler.
2013
-
Type I interferons: beneficial in Th1 and detrimental in Th17 autoimmunity.
Axtell RC,
Raman C, Steinman L.
Clin Rev Allergy Immunol.
2013;
44
(2):
114-20
-
Weighing in on autoimmune disease: 'Hub-and-spoke' T cell traffic in autoimmunity.
Steinman L,
Nat Med.
2013;
19
(2):
139-41
-
Chaperone activity of small heat shock proteins underlies therapeutic efficacy in experimental autoimmune encephalomyelitis.
Kurnellas MP,
Brownell SE, Su L, Malkovskiy AV, Rajadas J, Dolganov G, Chopra S, Schoolnik GK, Sobel RA, Webster J, Ousman SS, Becker RA, Steinman L, Rothbard JB.
J Biol Chem.
2012;
287
(43):
36423-34
-
Identification of naturally occurring fatty acids of the myelin sheath that resolve neuroinflammation.
Ho PP,
Kanter JL, Johnson AM, Srinagesh HK, Chang EJ, Purdy TM, van Haren K, Wikoff WR, Kind T, Khademi M, Matloff LY, Narayana S, Hur EM, Lindstrom TM, He Z, Fiehn O, Olsson T, Han X, Han MH, Steinman L, Robinson WH.
Sci Transl Med.
2012;
4
(137):
137ra73
-
Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice.
Han MH,
Lundgren DH, Jaiswal S, Chao M, Graham KL, Garris CS, Axtell RC, Ho PP, Lock CB, Woodard JI, Brownell SE, Zoudilova M, Hunt JF, Baranzini SE, Butcher EC, Raine CS, Sobel RA, Han DK, Weissman I, Steinman L.
J Exp Med.
2012;
209
(7):
1325-34
-
Lessons learned at the intersection of immunology and neuroscience.
Steinman L,
J Clin Invest.
2012;
122
(4):
1146-8
-
Nostalgia: the similarities between immunological and neurological memory.
Steinman L,
Immunol Rev.
2012;
248
(1):
5-9
-
Optimization of current and future therapy for autoimmune diseases.
Steinman L,
Merrill JT, McInnes IB, Peakman M.
Nat Med.
2012;
18
(1):
59-65
-
Peroxisome proliferator-activated receptor (PPAR)α and -γ regulate IFNγ and IL-17A production by human T cells in a sex-specific way.
Zhang MA,
Rego D, Moshkova M, Kebir H, Chruscinski A, Nguyen H, Akkermann R, Stanczyk FZ, Prat A, Steinman L, Dunn SE.
Proc Natl Acad Sci U S A.
2012;
109
(24):
9505-10
-
Platelets provide a bounty of potential targets for therapy in multiple sclerosis.
Steinman L,
Circ Res.
2012;
110
(9):
1157-8
-
Protective effect of an elastase inhibitor in a neuromyelitis optica-like disease driven by a peptide of myelin oligodendroglial glycoprotein.
Herges K,
de Jong BA, Kolkowitz I, Dunn C, Mandelbaum G, Ko RM, Maini A, Han MH, Killestein J, Polman C, Goodyear AL, Dunn J, Steinman L, Axtell RC.
Mult Scler.
2012;
18
(4):
398-408
-
Re-engineering of pathogenic aquaporin 4-specific antibodies as molecular decoys to treat neuromyelitis optica.
Steinman L,
Zamvil SS.
Ann Neurol.
2012;
71
(3):
287-8
-
Reversal of paralysis and reduced inflammation from peripheral administration of β-amyloid in TH1 and TH17 versions of experimental autoimmune encephalomyelitis.
Grant JL,
Ghosn EE, Axtell RC, Herges K, Kuipers HF, Woodling NS, Andreasson K, Herzenberg LA, Herzenberg LA, Steinman L.
Sci Transl Med.
2012;
4
(145):
145ra105
-
Serum IL-17F does not predict poor response to IM IFNβ-1a in relapsing-remitting MS.
Bushnell SE,
Zhao Z, Stebbins CC, Cadavid D, Buko AM, Whalley ET, Davis JA, Versage EM, Richert JR, Axtell RC, Steinman L, Medori R.
Neurology.
2012;
79
(6):
531-7
-
The discovery of natalizumab, a potent therapeutic for multiple sclerosis.
Steinman L,
J Cell Biol.
2012;
199
(3):
413-6
-
The protective and therapeutic function of small heat shock proteins in neurological diseases.
Brownell SE,
Becker RA, Steinman L.
Front Immunol.
2012:
3
74
-
Therapeutic effects of systemic administration of chaperone αB-crystallin associated with binding proinflammatory plasma proteins.
Rothbard JB,
Kurnellas MP, Brownell S, Adams CM, Su L, Axtell RC, Chen R, Fathman CG, Robinson WH, Steinman L.
J Biol Chem.
2012;
287
(13):
9708-21
-
Chaperone activity of α B-crystallin is responsible for its incorrect assignment as an autoantigen in multiple sclerosis.
Rothbard JB,
Zhao X, Sharpe O, Strohman MJ, Kurnellas M, Mellins ED, Robinson WH, Steinman L.
J Immunol.
2011;
186
(7):
4263-8
-
Combining statins with interferon β in multiple sclerosis: think twice, it might not be all right.
Zamvil SS,
Steinman L.
Lancet Neurol.
2011;
10
(8):
672-3
-
Common variants in P2RY11 are associated with narcolepsy.
Kornum BR,
Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, Mignot E.
Nat Genet.
2011;
43
(1):
66-71
-
Functional rescue of experimental ischemic optic neuropathy with αB-crystallin.
Pangratz-Fuehrer S,
Kaur K, Ousman SS, Steinman L, Liao YJ.
Eye (Lond).
2011;
25
(6):
809-17
-
Human peptidome display.
Robinson WH,
Steinman L.
Nat Biotechnol.
2011;
29
(6):
500-2
-
Interferon-β exacerbates Th17-mediated inflammatory disease.
Axtell RC,
Raman C, Steinman L.
Trends Immunol.
2011;
32
(6):
272-7
-
Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion.
Itoh S,
Kimura N, Axtell RC, Velotta JB, Gong Y, Wang X, Kajiwara N, Nambu A, Shimura E, Adachi H, Iwakura Y, Saito H, Okumura K, Sudo K, Steinman L, Robbins RC, Nakae S, Fischbein MP.
Circulation.
2011;
124
(11 Suppl):
S187-96
-
Systemic augmentation of alphaB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation.
Arac A,
Brownell SE, Rothbard JB, Chen C, Ko RM, Pereira MP, Albers GW, Steinman L, Steinberg GK.
Proc Natl Acad Sci U S A.
2011;
108
(32):
13287-92
-
Tyrosine kinase inhibitors ameliorate autoimmune encephalomyelitis in a mouse model of multiple sclerosis.
Crespo O,
Kang SC, Daneman R, Lindstrom TM, Ho PP, Sobel RA, Steinman L, Robinson WH.
J Clin Immunol.
2011;
31
(6):
1010-20
-
Vitamin D, pregnancy, breastfeeding, and postpartum multiple sclerosis relapses.
Langer-Gould A,
Huang S, Van Den Eeden SK, Gupta R, Leimpeter AD, Albers KB, Horst R, Hollis B, Steinman L, Nelson LM.
Arch Neurol.
2011;
68
(3):
310-3
-
αB-crystallin improves murine cardiac function and attenuates apoptosis in human endothelial cells exposed to ischemia-reperfusion.
Velotta JB,
Kimura N, Chang SH, Chung J, Itoh S, Rothbard J, Yang PC, Steinman L, Robbins RC, Fischbein MP.
Ann Thorac Surg.
2011;
91
(6):
1907-13
-
Alphab-crystallin is a target for adaptive immune responses and a trigger of innate responses in preactive multiple sclerosis lesions.
van Noort JM,
Bsibsi M, Gerritsen WH, van der Valk P, Bajramovic JJ, Steinman L, Amor S.
J Neuropathol Exp Neurol.
2010;
69
(7):
694-703
-
Angiotensin II sustains brain inflammation in mice via TGF-beta.
Lanz TV,
Ding Z, Ho PP, Luo J, Agrawal AN, Srinagesh H, Axtell R, Zhang H, Platten M, Wyss-Coray T, Steinman L.
J Clin Invest.
2010;
120
(8):
2782-94
-
Autoimmunity against fibrinogen mediates inflammatory arthritis in mice.
Ho PP,
Lee LY, Zhao X, Tomooka BH, Paniagua RT, Sharpe O, BenBarak MJ, Chandra PE, Hueber W, Steinman L, Robinson WH.
J Immunol.
2010;
184
(1):
379-90
-
Delivery of myelin peptides through the first line of defense, skin, to counter autoimmunity in multiple sclerosis.
Steinman L,
Zamvil SS.
Ann Neurol.
2010;
68
(5):
567-9
-
IL-17 contributes to the development of chronic rejection in a murine heart transplant model.
Itoh S,
Nakae S, Axtell RC, Velotta JB, Kimura N, Kajiwara N, Iwakura Y, Saito H, Adachi H, Steinman L, Robbins RC, Fischbein MP.
J Clin Immunol.
2010;
30
(2):
235-40
-
Inhibitory role for GABA in autoimmune inflammation.
Bhat R,
Axtell R, Mitra A, Miranda M, Lock C, Tsien RW, Steinman L.
Proc Natl Acad Sci U S A.
2010;
107
(6):
2580-5
-
Interferon-gamma-producing T cells, pregnancy, and postpartum relapses of multiple sclerosis.
Langer-Gould A,
Gupta R, Huang S, Hagan A, Atkuri K, Leimpeter AD, Albers KB, Greenwood E, Van Den Eeden SK, Steinman L, Nelson LM.
Arch Neurol.
2010;
67
(1):
51-7
-
Inverse vaccination to silence immunity to myelin in multiple sclerosis.
Steinman L,
Can J Neurol Sci.
2010:
37 Suppl 2
S49-58
-
Inverse vaccination, the opposite of Jenner's concept, for therapy of autoimmunity.
Steinman L,
J Intern Med.
2010;
267
(5):
441-51
-
Mixed results with modulation of TH-17 cells in human autoimmune diseases.
Steinman L,
Nat Immunol.
2010;
11
(1):
41-4
-
Modulation of postoperative cognitive decline via blockade of inflammatory cytokines outside the brain.
Steinman L,
Proc Natl Acad Sci U S A.
2010;
107
(48):
20595-6
-
Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity.
Dunn SE,
Bhat R, Straus DS, Sobel RA, Axtell R, Johnson A, Nguyen K, Mukundan L, Moshkova M, Dugas JC, Chawla A, Steinman L.
J Exp Med.
2010;
207
(8):
1599-608
-
Socioeconomic trends in hospitalization for multiple sclerosis.
Lad SP,
Chapman CH, Vaninetti M, Steinman L, Green A, Boakye M.
Neuroepidemiology.
2010;
35
(2):
93-9
-
T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis.
Axtell RC,
de Jong BA, Boniface K, van der Voort LF, Bhat R, De Sarno P, Naves R, Han M, Zhong F, Castellanos JG, Mair R, Christakos A, Kolkowitz I, Katz L, Killestein J, Polman CH, de Waal Malefyt R, Steinman L, Raman C.
Nat Med.
2010;
16
(4):
406-12
-
Treatment with a toll-like receptor inhibitory GpG oligonucleotide delays and attenuates lupus nephritis in NZB/W mice.
Graham KL,
Lee LY, Higgins JP, Steinman L, Utz PJ, Ho PP.
Autoimmunity.
2010;
43
(2):
140-55
-
A molecular trio in relapse and remission in multiple sclerosis.
Steinman L,
Nat Rev Immunol.
2009;
9
(6):
440-7
-
Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity.
Platten M,
Youssef S, Hur EM, Ho PP, Han MH, Lanz TV, Phillips LK, Goldstein MJ, Bhat R, Raine CS, Sobel RA, Steinman L.
Proc Natl Acad Sci U S A.
2009;
106
(35):
14948-53
-
Enhanced immune recognition of cryptic glycan markers in human tumors.
Newsom-Davis TE,
Wang D, Steinman L, Chen PF, Wang LX, Simon AK, Screaton GR.
Cancer Res.
2009;
69
(5):
2018-25
-
HMG-CoA reductase inhibition causes increased necrosis and apoptosis in an in vivo mouse glioblastoma multiforme model.
Bababeygy SR,
Polevaya NV, Youssef S, Sun A, Xiong A, Prugpichailers T, Veeravagu A, Hou LC, Steinman L, Tse V.
Anticancer Res.
2009;
29
(12):
4901-8
-
Innate and adaptive autoimmunity directed to the central nervous system.
Bhat R,
Steinman L.
Neuron.
2009;
64
(1):
123-32
-
PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance.
Mukundan L,
Odegaard JI, Morel CR, Heredia JE, Mwangi JW, Ricardo-Gonzalez RR, Goh YP, Eagle AR, Dunn SE, Awakuni JU, Nguyen KD, Steinman L, Michie SA, Chawla A.
Nat Med.
2009;
15
(11):
1266-72
-
Shifting therapeutic attention in MS to osteopontin, type 1 and type 2 IFN.
Steinman L,
Eur J Immunol.
2009;
39
(9):
2358-60
-
Systems biology for identification of molecular networks in multiple sclerosis.
Han MH,
Steinman L.
Mult Scler.
2009;
15
(5):
529-30
-
The gray aspects of white matter disease in multiple sclerosis.
Steinman L,
Proc Natl Acad Sci U S A.
2009;
106
(20):
8083-4
-
A rush to judgment on Th17.
Steinman L,
J Exp Med.
2008;
205
(7):
1517-22
-
Bioluminescence in vivo imaging of autoimmune encephalomyelitis predicts disease.
Luo J,
Ho P, Steinman L, Wyss-Coray T.
J Neuroinflammation.
2008:
5
6
-
CD4+CD25+ regulatory T cells specific for a thymus-expressed antigen prevent the development of anaphylaxis to self.
Scabeni S,
Lapilla M, Musio S, Gallo B, Ciusani E, Steinman L, Mantegazza R, Pedotti R.
J Immunol.
2008;
180
(7):
4433-40
-
Differential regulation of chemokines by IL-17 in colonic epithelial cells.
Lee JW,
Wang P, Kattah MG, Youssef S, Steinman L, DeFea K, Straus DS.
J Immunol.
2008;
181
(9):
6536-45
-
Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination.
Kidd BA,
Ho PP, Sharpe O, Zhao X, Tomooka BH, Kanter JL, Steinman L, Robinson WH.
Arthritis Res Ther.
2008;
10
(5):
R119
-
Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation.
Johansson CB,
Youssef S, Koleckar K, Holbrook C, Doyonnas R, Corbel SY, Steinman L, Rossi FM, Blau HM.
Nat Cell Biol.
2008;
10
(5):
575-83
-
Failure of oral atorvastatin to modulate a murine model of systemic lupus erythematosus.
Graham KL,
Lee LY, Higgins JP, Steinman L, Utz PJ, Ho PP.
Arthritis Rheum.
2008;
58
(7):
2098-104
-
Improved efficacy of a tolerizing DNA vaccine for reversal of hyperglycemia through enhancement of gene expression and localization to intracellular sites.
Solvason N,
Lou YP, Peters W, Evans E, Martinez J, Ramirez U, Ocampo A, Yun R, Ahmad S, Liu E, Yu L, Eisenbarth G, Leviten M, Steinman L, Garren H.
J Immunol.
2008;
181
(12):
8298-307
-
New targets for treatment of multiple sclerosis.
Steinman L,
J Neurol Sci.
2008;
274
(1-2):
1-4
-
Nuanced roles of cytokines in three major human brain disorders.
Steinman L,
J Clin Invest.
2008;
118
(11):
3557-63
-
Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis.
Garren H,
Robinson WH, Krasulová E, Havrdová E, Nadj C, Selmaj K, Losy J, Nadj I, Radue EW, Kidd BA, Gianettoni J, Tersini K, Utz PJ, Valone F, Steinman L.
Ann Neurol.
2008;
63
(5):
611-20
-
Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets.
Han MH,
Hwang SI, Roy DB, Lundgren DH, Price JV, Ousman SS, Fernald GH, Gerlitz B, Robinson WH, Baranzini SE, Grinnell BW, Raine CS, Sobel RA, Han DK, Steinman L.
Nature.
2008;
451
(7182):
1076-81
-
The aryl hydrocarbon receptor: a regulator of Th17 and Treg cell development in disease.
Ho PP,
Steinman L.
Cell Res.
2008;
18
(6):
605-8
-
Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma.
Jensen KD,
Su X, Shin S, Li L, Youssef S, Yamasaki S, Steinman L, Saito T, Locksley RM, Davis MM, Baumgarth N, Chien YH.
Immunity.
2008;
29
(1):
90-100
-
Type 1 interferons cool the inflamed brain.
Axtell RC,
Steinman L.
Immunity.
2008;
28
(5):
600-2
-
A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage.
Steinman L,
Nat Med.
2007;
13
(2):
139-45
-
Antigen-specific therapy of multiple sclerosis: the long-sought magic bullet.
Steinman L,
Neurotherapeutics.
2007;
4
(4):
661-5
-
Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis.
Luo J,
Ho PP, Buckwalter MS, Hsu T, Lee LY, Zhang H, Kim DK, Kim SJ, Gambhir SS, Steinman L, Wyss-Coray T.
J Clin Invest.
2007;
117
(11):
3306-15
-
Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation.
Chora AA,
Fontoura P, Cunha A, Pais TF, Cardoso S, Ho PP, Lee LY, Sobel RA, Steinman L, Soares MP.
J Clin Invest.
2007;
117
(2):
438-47
-
Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase 1/2 trial.
Bar-Or A,
Vollmer T, Antel J, Arnold DL, Bodner CA, Campagnolo D, Gianettoni J, Jalili F, Kachuck N, Lapierre Y, Niino M, Oger J, Price M, Rhodes S, Robinson WH, Shi FD, Utz PJ, Valone F, Weiner L, Steinman L, Garren H.
Arch Neurol.
2007;
64
(10):
1407-15
-
Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis.
Shachaf CM,
Perez OD, Youssef S, Fan AC, Elchuri S, Goldstein MJ, Shirer AE, Sharpe O, Chen J, Mitchell DJ, Chang M, Nolan GP, Steinman L, Felsher DW.
Blood.
2007;
110
(7):
2674-84
-
Nanosensor detection of an immunoregulatory tryptophan influx/kynurenine efflux cycle.
Kaper T,
Looger LL, Takanaga H, Platten M, Steinman L, Frommer WB.
PLoS Biol.
2007;
5
(10):
e257
-
Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells.
Hur EM,
Youssef S, Haws ME, Zhang SY, Sobel RA, Steinman L.
Nat Immunol.
2007;
8
(1):
74-83
-
Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity.
Dunn SE,
Ousman SS, Sobel RA, Zuniga L, Baranzini SE, Youssef S, Crowell A, Loh J, Oksenberg J, Steinman L.
J Exp Med.
2007;
204
(2):
321-30
-
Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity.
Zeiser R,
Youssef S, Baker J, Kambham N, Steinman L, Negrin RS.
Blood.
2007;
110
(13):
4588-98
-
Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination.
Ousman SS,
Tomooka BH, van Noort JM, Wawrousek EF, O'Connor KC, Hafler DA, Sobel RA, Robinson WH, Steinman L.
Nature.
2007;
448
(7152):
474-9
-
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein.
O'Connor KC,
McLaughlin KA, De Jager PL, Chitnis T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong SJ, Tavakoli NP, Idrissova Z, Viglietta V, Rostasy K, Pohl D, Dale RC, Freedman M, Steinman L, Buckle GJ, Kuchroo VK, Hafler DA, Wucherpfennig KW.
Nat Med.
2007;
13
(2):
211-7
-
Statins--treatment option for central nervous system autoimmune disease?
Weber MS,
Steinman L, Zamvil SS.
Neurotherapeutics.
2007;
4
(4):
693-700
-
Tryptophan degradation in autoimmune diseases.
Opitz CA,
Wick W, Steinman L, Platten M.
Cell Mol Life Sci.
2007;
64
(19-20):
2542-63
-
Type II monocytes modulate T cell-mediated central nervous system autoimmune disease.
Weber MS,
Prod'homme T, Youssef S, Dunn SE, Rundle CD, Lee L, Patarroyo JC, Stüve O, Sobel RA, Steinman L, Zamvil SS.
Nat Med.
2007;
13
(8):
935-43
-
A key regulatory role for histamine in experimental autoimmune encephalomyelitis: disease exacerbation in histidine decarboxylase-deficient mice.
Musio S,
Gallo B, Scabeni S, Lapilla M, Poliani PL, Matarese G, Ohtsu H, Galli SJ, Mantegazza R, Steinman L, Pedotti R.
J Immunol.
2006;
176
(1):
17-26
-
A neuropeptide in immune-mediated inflammation, Y?
Prod'homme T,
Weber MS, Steinman L, Zamvil SS.
Trends Immunol.
2006;
27
(4):
164-7
-
At once harmful and beneficial: the dual properties of NF-kappaB.
Youssef S,
Steinman L.
Nat Immunol.
2006;
7
(9):
901-2
-
Controlling autoimmunity in sporadic inclusion-body myositis.
Steinman L,
Neurology.
2006;
66
(2 Suppl 1):
S56-8
-
Emerging therapeutic targets in multiple sclerosis.
Fontoura P,
Steinman L, Miller A.
Curr Opin Neurol.
2006;
19
(3):
260-6
-
How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis.
Steinman L,
Zamvil SS.
Ann Neurol.
2006;
60
(1):
12-21
-
Immunomodulatory synergy by combination of atorvastatin and glatiramer acetate in treatment of CNS autoimmunity.
Stüve O,
Youssef S, Weber MS, Nessler S, von Büdingen HC, Hemmer B, Prod'homme T, Sobel RA, Steinman L, Zamvil SS.
J Clin Invest.
2006;
116
(4):
1037-44
-
Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin.
Dunn SE,
Youssef S, Goldstein MJ, Prod'homme T, Weber MS, Zamvil SS, Steinman L.
J Exp Med.
2006;
203
(2):
401-12
-
Lipid microarrays identify key mediators of autoimmune brain inflammation.
Kanter JL,
Narayana S, Ho PP, Catz I, Warren KG, Sobel RA, Steinman L, Robinson WH.
Nat Med.
2006;
12
(1):
138-43
-
Most patients with multiple sclerosis or a clinically isolated demyelinating syndrome should be treated at the time of diagnosis.
Frohman EM,
Havrdova E, Lublin F, Barkhof F, Achiron A, Sharief MK, Stuve O, Racke MK, Steinman L, Weiner H, Olek M, Zivadinov R, Corboy J, Raine C, Cutter G, Richert J, Filippi M.
Arch Neurol.
2006;
63
(4):
614-9
-
Nogo in multiple sclerosis: growing roles of a growth inhibitor.
Fontoura P,
Steinman L.
J Neurol Sci.
2006;
245
(1-2):
201-10
-
Progressive multifocal leukoencephalopathy and multiple sclerosis: lessons from natalizumab.
Langer-Gould A,
Steinman L.
Curr Neurol Neurosci Rep.
2006;
6
(3):
253-8
-
Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis.
Paniagua RT,
Sharpe O, Ho PP, Chan SM, Chang A, Higgins JP, Tomooka BH, Thomas FM, Song JJ, Goodman SB, Lee DM, Genovese MC, Utz PJ, Steinman L, Robinson WH.
J Clin Invest.
2006;
116
(10):
2633-42
-
State of the art. Four easy pieces: interconnections between tissue injury, intermediary metabolism, autoimmunity, and chronic degeneration.
Steinman L,
Proc Am Thorac Soc.
2006;
3
(6):
484-6
-
Statin therapy and autoimmune disease: from protein prenylation to immunomodulation.
Greenwood J,
Steinman L, Zamvil SS.
Nat Rev Immunol.
2006;
6
(5):
358-70
-
Statins in the treatment of central nervous system autoimmune disease.
Weber MS,
Youssef S, Dunn SE, Prod'homme T, Neuhaus O, Stuve O, Greenwood J, Steinman L, Zamvil SS.
J Neuroimmunol.
2006;
178
(1-2):
140-8
-
The coming of age for antigen-specific therapy of multiple sclerosis.
Steinman L,
Eur J Neurol.
2006;
13
(8):
793-4
-
Tolerizing DNA vaccines for autoimmune arthritis.
Ho PP,
Higgins JP, Kidd BA, Tomooka B, Digennaro C, Lee LY, de Vegvar HE, Steinman L, Robinson WH.
Autoimmunity.
2006;
39
(8):
675-82
-
What went wrong in the natalizumab trials?
Langer-Gould A,
Steinman L.
Lancet.
2006;
367
(9512):
708-10
-
Antigen-specific therapies in multiple sclerosis: going beyond proteins and peptides.
Fontoura P,
Garren H, Steinman L.
Int Rev Immunol.
2005 Sep-Dec;
24
(5-6):
415-46
-
A suppressive oligodeoxynucleotide enhances the efficacy of myelin cocktail/IL-4-tolerizing DNA vaccination and treats autoimmune disease.
Ho PP,
Fontoura P, Platten M, Sobel RA, DeVoss JJ, Lee LY, Kidd BA, Tomooka BH, Capers J, Agrawal A, Gupta R, Zernik J, Yee MK, Lee BJ, Garren H, Robinson WH, Steinman L.
J Immunol.
2005;
175
(9):
6226-34
-
Blocking adhesion molecules as therapy for multiple sclerosis: natalizumab.
Steinman L,
Nat Rev Drug Discov.
2005;
4
(6):
510-8
-
Characterizing the mechanisms of progression in multiple sclerosis: evidence and new hypotheses for future directions.
Frohman EM,
Filippi M, Stuve O, Waxman SG, Corboy J, Phillips JT, Lucchinetti C, Wilken J, Karandikar N, Hemmer B, Monson N, De Keyser J, Hartung H, Steinman L, Oksenberg JR, Cree BA, Hauser S, Racke MK.
Arch Neurol.
2005;
62
(9):
1345-56
-
Controlling autoimmunity in sporadic inclusion-body myositis.
Steinman L,
Neurology.
2005
-
Design of effective immunotherapy for human autoimmunity.
Feldmann M,
Steinman L.
Nature.
2005;
435
(7042):
612-9
-
Drug Insight: using statins to treat neuroinflammatory disease.
Weber MS,
Prod'homme T, Steinman L, Zamvil SS.
Nat Clin Pract Neurol.
2005;
1
(2):
106-12
-
Multiple sclerosis: trapped in deadly glue.
Platten M,
Steinman L.
Nat Med.
2005;
11
(3):
252-3
-
Suppression of autoimmunity via microbial mimics of altered peptide ligands.
Steinman L,
Utz PJ, Robinson WH.
Curr Top Microbiol Immunol.
2005:
296
55-63
-
Therapeutic considerations for disease progression in multiple sclerosis: evidence, experience, and future expectations.
Frohman EM,
Stüve O, Havrdova E, Corboy J, Achiron A, Zivadinov R, Sorensen PS, Phillips JT, Weinshenker B, Hawker K, Hartung HP, Steinman L, Zamvil S, Cree BA, Hauser S, Weiner H, Racke MK, Filippi M.
Arch Neurol.
2005;
62
(10):
1519-30
-
Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite.
Platten M,
Ho PP, Youssef S, Fontoura P, Garren H, Hur EM, Gupta R, Lee LY, Kidd BA, Robinson WH, Sobel RA, Selley ML, Steinman L.
Science.
2005;
310
(5749):
850-5
-
Virtues and pitfalls of EAE for the development of therapies for multiple sclerosis.
Steinman L,
Zamvil SS.
Trends Immunol.
2005;
26
(11):
565-71
-
Elaborate interactions between the immune and nervous systems.
Steinman L,
Nat Immunol.
2004;
5
(6):
575-81
-
High-throughput methods for measuring autoantibodies in systemic lupus erythematosus and other autoimmune diseases.
Graham KL,
Robinson WH, Steinman L, Utz PJ.
Autoimmunity.
2004;
37
(4):
269-72
-
Immune therapy for autoimmune diseases.
Steinman L,
Science.
2004;
305
(5681):
212-6
-
Immunity to the extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis.
Fontoura P,
Ho PP, DeVoss J, Zheng B, Lee BJ, Kidd BA, Garren H, Sobel RA, Robinson WH, Tessier-Lavigne M, Steinman L.
J Immunol.
2004;
173
(11):
6981-92
-
Statins as potential therapeutic agents in multiple sclerosis.
Stüve O,
Prod'homme T, Youssef S, Dunn S, Neuhaus O, Weber M, Hartung HP, Steinman L, Zamvil SS.
Curr Neurol Neurosci Rep.
2004;
4
(3):
237-44
-
The multifaceted role of transglutaminase in neurodegeneration: review article.
Karpuj M,
Steinman L.
Amino Acids.
2004;
26
(4):
373-9
-
An immunomodulatory GpG oligonucleotide for the treatment of autoimmunity via the innate and adaptive immune systems.
Ho PP,
Fontoura P, Ruiz PJ, Steinman L, Garren H.
J Immunol.
2003;
171
(9):
4920-6
-
Diverse targets for intervention during inflammatory and neurodegenerative phases of multiple sclerosis.
Zamvil SS,
Steinman L.
Neuron.
2003;
38
(5):
685-8
-
Engineering better cytokines.
Steinman L,
Nat Biotechnol.
2003;
21
(11):
1293-4
-
Genomic and proteomic analysis of multiple sclerosis. Opinion.
Robinson WH,
Utz PJ, Steinman L.
Curr Opin Immunol.
2003;
15
(6):
660-7
-
Involvement of both 'allergic' and 'autoimmune' mechanisms in EAE, MS and other autoimmune diseases.
Pedotti R,
De Voss JJ, Steinman L, Galli SJ.
Trends Immunol.
2003;
24
(9):
479-84
-
Medicine: Collateral damage repaired.
Steinman L,
Nature.
2003;
422
(6933):
671-2
-
Microarray profiling of antibody responses against simian-human immunodeficiency virus: postchallenge convergence of reactivities independent of host histocompatibility type and vaccine regimen.
Neuman de Vegvar HE,
Amara RR, Steinman L, Utz PJ, Robinson HL, Robinson WH.
J Virol.
2003;
77
(20):
11125-38
-
Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination.
Pedotti R,
DeVoss JJ, Youssef S, Mitchell D, Wedemeyer J, Madanat R, Garren H, Fontoura P, Tsai M, Galli SJ, Sobel RA, Steinman L.
Proc Natl Acad Sci U S A.
2003;
100
(4):
1867-72
-
Optic neuritis, a new variant of experimental encephalomyelitis, a durable model for all seasons, now in its seventieth year.
Steinman L,
J Exp Med.
2003;
197
(9):
1065-71
-
Osteopontin polymorphisms and disease course in multiple sclerosis.
Caillier S,
Barcellos LF, Baranzini SE, Swerdlin A, Lincoln RR, Steinman L, Martin E, Haines JL, Pericak-Vance M, Hauser SL, Oksenberg JR.
Genes Immun.
2003;
4
(4):
312-5
-
Protein arrays for autoantibody profiling and fine-specificity mapping.
Robinson WH,
Steinman L, Utz PJ.
Proteomics.
2003;
3
(11):
2077-84
-
Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis.
Robinson WH,
Fontoura P, Lee BJ, de Vegvar HE, Tom J, Pedotti R, DiGennaro CD, Mitchell DJ, Fong D, Ho PP, Ruiz PJ, Maverakis E, Stevens DB, Bernard CC, Martin R, Kuchroo VK, van Noort JM, Genain CP, Amor S, Olsson T, Utz PJ, Garren H, Steinman L.
Nat Biotechnol.
2003;
21
(9):
1033-9
-
Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus.
Pedotti R,
Sanna M, Tsai M, DeVoss J, Steinman L, McDevitt H, Galli SJ.
BMC Immunol.
2003:
4
2
-
Statins and their potential targets in multiple sclerosis therapy.
Stüve O,
Prod'homme T, Slavin A, Youssef S, Dunn S, Steinman L, Zamvil SS.
Expert Opin Ther Targets.
2003;
7
(5):
613-22
-
Statins as potential therapeutic agents in neuroinflammatory disorders.
Stüve O,
Youssef S, Steinman L, Zamvil SS.
Curr Opin Neurol.
2003;
16
(3):
393-401
-
The intricate interplay among body weight, stress, and the immune response to friend or foe.
Steinman L,
Conlon P, Maki R, Foster A.
J Clin Invest.
2003;
111
(2):
183-5
-
The potential therapeutic role of statins in central nervous system autoimmune disorders.
Stüve O,
Youssef S, Dunn S, Slavin AJ, Steinman L, Zamvil SS.
Cell Mol Life Sci.
2003;
60
(11):
2483-91
-
Transcriptional analysis of targets in multiple sclerosis.
Steinman L,
Zamvil S.
Nat Rev Immunol.
2003;
3
(6):
483-92
-
Altered peptide ligands and MS treatment.
Conlon P,
Steinman L.
Science.
2002;
296
(5574):
1801-2; author reply 1801-2
-
Approved and future pharmacotherapy for multiple sclerosis.
Stüve O,
Cree BC, von Büdingen HC, Yousef S, Bowen JD, Genain CP, Hauser SL, Steinman L, Zamvil SS.
Neurologist.
2002;
8
(5):
290-301
-
Autoantibody profiling for the study and treatment of autoimmune disease.
Hueber W,
Utz PJ, Steinman L, Robinson WH.
Arthritis Res.
2002;
4
(5):
290-5
-
Autoantigen microarrays for multiplex characterization of autoantibody responses.
Robinson WH,
DiGennaro C, Hueber W, Haab BB, Kamachi M, Dean EJ, Fournel S, Fong D, Genovese MC, de Vegvar HE, Skriner K, Hirschberg DL, Morris RI, Muller S, Pruijn GJ, van Venrooij WJ, Smolen JS, Brown PO, Steinman L, Utz PJ.
Nat Med.
2002;
8
(3):
295-301
-
Cholesterol-lowering statins possess anti-inflammatory activity that might be useful for treatment of MS.
Zamvil SS,
Steinman L.
Neurology.
2002;
59
(7):
970-1
-
Evidence for a role for transglutaminase in Huntington's disease and the potential therapeutic implications.
Karpuj MV,
Becher MW, Steinman L.
Neurochem Int.
2002;
40
(1):
31-6
-
Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis.
Lock C,
Hermans G, Pedotti R, Brendolan A, Schadt E, Garren H, Langer-Gould A, Strober S, Cannella B, Allard J, Klonowski P, Austin A, Lad N, Kaminski N, Galli SJ, Oksenberg JR, Raine CS, Heller R, Steinman L.
Nat Med.
2002;
8
(5):
500-8
-
Immunomodulatory vaccination in autoimmune disease.
Urbanek-Ruiz I,
Ruiz PJ, Steinman L, Fathman CG.
Endocrinol Metab Clin North Am.
2002;
31
(2):
441-56, viii-ix
-
Late pregnancy suppresses relapses in experimental autoimmune encephalomyelitis: evidence for a suppressive pregnancy-related serum factor.
Langer-Gould A,
Garren H, Slansky A, Ruiz PJ, Steinman L.
J Immunol.
2002;
169
(2):
1084-91
-
Millennium Award. Proteomics for the development of DNA tolerizing vaccines to treat autoimmune disease.
Robinson WH,
Garren H, Utz PJ, Steinman L.
Clin Immunol.
2002;
103
(1):
7-12
-
Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy.
Steinman L,
Martin R, Bernard C, Conlon P, Oksenberg JR.
Annu Rev Neurosci.
2002:
25
491-505
-
Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine.
Karpuj MV,
Becher MW, Springer JE, Chabas D, Youssef S, Pedotti R, Mitchell D, Steinman L.
Nat Med.
2002;
8
(2):
143-9
-
Protein and peptide array analysis of autoimmune disease.
Robinson WH,
Steinman L, Utz PJ.
Biotechniques.
2002:
Suppl
66-9
-
Proteomics technologies for the study of autoimmune disease.
Robinson WH,
Steinman L, Utz PJ.
Arthritis Rheum.
2002;
46
(4):
885-93
-
The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease.
Youssef S,
Stüve O, Patarroyo JC, Ruiz PJ, Radosevich JL, Hur EM, Bravo M, Mitchell DJ, Sobel RA, Steinman L, Zamvil SS.
Nature.
2002;
420
(6911):
78-84
-
An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide.
Pedotti R,
Mitchell D, Wedemeyer J, Karpuj M, Chabas D, Hattab EM, Tsai M, Galli SJ, Steinman L.
Nat Immunol.
2001;
2
(3):
216-22
-
Antigen specific immunotherapy of multiple sclerosis.
Steinman L,
Conlon P.
J Clin Immunol.
2001;
21
(2):
93-8
-
Blockade of gamma interferon might be beneficial in MS.
Steinman L,
Mult Scler.
2001;
7
(5):
275-6
-
Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway.
Garren H,
Ruiz PJ, Watkins TA, Fontoura P, Nguyen LT, Estline ER, Hirschberg DL, Steinman L.
Immunity.
2001;
15
(1):
15-22
-
Evaluating human T cell receptor gene expression by PCR.
Gussoni E,
Panzara MA, Steinman L.
Curr Protoc Immunol.
2001:
Chapter 10
Unit 10.26
-
Gene microarrays and experimental demyelinating disease: a tool to enhance serendipity.
Steinman L,
Brain.
2001;
124
(Pt 10):
1897-9
-
Immunization with DNA encoding an immunodominant peptide of insulin prevents diabetes in NOD mice.
Urbanek-Ruiz I,
Ruiz PJ, Paragas V, Garren H, Steinman L, Fathman CG.
Clin Immunol.
2001;
100
(2):
164-71
-
Immunomodulation of experimental autoimmune encephalomyelitis with ordered peptides based on MHC-TCR binding motifs.
Ruiz PJ,
DeVoss JJ, Nguyen LV, Fontoura PP, Hirschberg DL, Mitchell DJ, Garcia KC, Steinman L.
J Immunol.
2001;
167
(5):
2688-93
-
Immunotherapy of multiple sclerosis: the end of the beginning.
Steinman L,
Curr Opin Immunol.
2001;
13
(5):
597-600
-
Multiple sclerosis and gene expression profiling.
Steinman L,
Adv Exp Med Biol.
2001:
490
109-12
-
Multiple sclerosis: a two-stage disease.
Steinman L,
Nat Immunol.
2001;
2
(9):
762-4
-
Myelin-specific CD8 T cells in the pathogenesis of experimental allergic encephalitis and multiple sclerosis.
Steinman L,
J Exp Med.
2001;
194
(5):
F27-30
-
N(epsilon)-(gamma-L-glutamyl)-L-lysine (GGEL) is increased in cerebrospinal fluid of patients with Huntington's disease.
Jeitner TM,
Bogdanov MB, Matson WR, Daikhin Y, Yudkoff M, Folk JE, Steinman L, Browne SE, Beal MF, Blass JP, Cooper AJ.
J Neurochem.
2001;
79
(5):
1109-12
-
Posttraumatic therapeutic vaccination with modified myelin self-antigen prevents complete paralysis while avoiding autoimmune disease.
Hauben E,
Agranov E, Gothilf A, Nevo U, Cohen A, Smirnov I, Steinman L, Schwartz M.
J Clin Invest.
2001;
108
(4):
591-9
-
The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease.
Chabas D,
Baranzini SE, Mitchell D, Bernard CC, Rittling SR, Denhardt DT, Sobel RA, Lock C, Karpuj M, Pedotti R, Heller R, Oksenberg JR, Steinman L.
Science.
2001;
294
(5547):
1731-5
-
DNA vaccination in the treatment of autoimmune disease.
Garren H,
Steinman L.
Curr Dir Autoimmun.
2000:
2
203-16
-
Despite epitope spreading in the pathogenesis of autoimmune disease, highly restricted approaches to immune therapy may still succeed [with a hedge on this bet].
Steinman L,
J Autoimmun.
2000;
14
(4):
278-82
-
Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis.
Voehringer DW,
Hirschberg DL, Xiao J, Lu Q, Roederer M, Lock CB, Herzenberg LA, Steinman L, Herzenberg LA.
Proc Natl Acad Sci U S A.
2000;
97
(6):
2680-5
-
ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging.
Sipkins DA,
Gijbels K, Tropper FD, Bednarski M, Li KC, Steinman L.
J Neuroimmunol.
2000;
104
(1):
1-9
-
Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The Altered Peptide Ligand in Relapsing MS Study Group.
Kappos L,
Comi G, Panitch H, Oger J, Antel J, Conlon P, Steinman L.
Nat Med.
2000;
6
(10):
1176-82
-
Multiple approaches to multiple sclerosis.
Steinman L,
Nat Med.
2000;
6
(1):
15-6
-
Polyarginine enters cells more efficiently than other polycationic homopolymers.
Mitchell DJ,
Kim DT, Steinman L, Fathman CG, Rothbard JB.
J Pept Res.
2000;
56
(5):
318-25
-
The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters.
Wender PA,
Mitchell DJ, Pattabiraman K, Pelkey ET, Steinman L, Rothbard JB.
Proc Natl Acad Sci U S A.
2000;
97
(24):
13003-8
-
Absence of "original antigenic sin" in autoimmunity provides an unforeseen platform for immune therapy.
Steinman L,
J Exp Med.
1999;
189
(7):
1021-4
-
Antibodies to CD44 and integrin alpha4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment.
Brocke S,
Piercy C, Steinman L, Weissman IL, Veromaa T.
Proc Natl Acad Sci U S A.
1999;
96
(12):
6896-901
-
Assessment of animal models for MS and demyelinating disease in the design of rational therapy.
Steinman L,
Neuron.
1999;
24
(3):
511-4
-
Local delivery of TNF by retrovirus-transduced T lymphocytes exacerbates experimental autoimmune encephalomyelitis.
Dal Canto RA,
Shaw MK, Nolan GP, Steinman L, Fathman CG.
Clin Immunol.
1999;
90
(1):
10-4
-
Microbial epitopes act as altered peptide ligands to prevent experimental autoimmune encephalomyelitis.
Ruiz PJ,
Garren H, Hirschberg DL, Langer-Gould AM, Levite M, Karpuj MV, Southwood S, Sette A, Conlon P, Steinman L.
J Exp Med.
1999;
189
(8):
1275-84
-
Non-coding plasmid DNA induces IFN-gamma in vivo and suppresses autoimmune encephalomyelitis.
Boccaccio GL,
Mor F, Steinman L.
Int Immunol.
1999;
11
(2):
289-96
-
Pick your fights wisely.
Steinman L,
Curr Opin Neurol.
1999;
12
(4):
375-6
-
Selection of hprt mutant T cells as surrogates for dividing cells reveals a restricted T cell receptor BV repertoire in insulin-dependent diabetes mellitus.
Falta MT,
Magin GK, Allegretta M, Steinman L, Atkinson MA, Brostoff SW, Albertini RJ.
Clin Immunol.
1999;
90
(3):
340-51
-
Suppressive immunization with DNA encoding a self-peptide prevents autoimmune disease: modulation of T cell costimulation.
Ruiz PJ,
Garren H, Ruiz IU, Hirschberg DL, Nguyen LV, Karpuj MV, Cooper MT, Mitchell DJ, Fathman CG, Steinman L.
J Immunol.
1999;
162
(6):
3336-41
-
T cell receptor BV gene rearrangements in the spinal cords and cerebrospinal fluid of patients with amyotrophic lateral sclerosis.
Panzara MA,
Gussoni E, Begovich AB, Murray RS, Zang YQ, Appel SH, Steinman L, Zhang J.
Neurobiol Dis.
1999;
6
(5):
392-405
-
The immunobiology of multiple sclerosis: an autoimmune disease of the central nervous system.
Conlon P,
Oksenberg JR, Zhang J, Steinman L.
Neurobiol Dis.
1999;
6
(3):
149-66
-
The role of TNFalpha and lymphotoxin in demyelinating disease.
Lock C,
Oksenberg J, Steinman L.
Ann Rheum Dis.
1999:
58 Suppl 1
I121-8
-
Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nuclei.
Karpuj MV,
Garren H, Slunt H, Price DL, Gusella J, Becher MW, Steinman L.
Proc Natl Acad Sci U S A.
1999;
96
(13):
7388-93
-
A viral peptide with limited homology to a self peptide can induce clinical signs of experimental autoimmune encephalomyelitis.
Gautam AM,
Liblau R, Chelvanayagam G, Steinman L, Boston T.
J Immunol.
1998;
161
(1):
60-4
-
Idiotypic immunization induces immunity to mutated p53 and tumor rejection.
Ruiz PJ,
Wolkowicz R, Waisman A, Hirschberg DL, Carmi P, Erez N, Garren H, Herkel J, Karpuj M, Steinman L, Rotter V, Cohen IR.
Nat Med.
1998;
4
(6):
710-2
-
Microbial peptides and superantigens in the pathogenesis of autoimmune diseases of the central nervous system.
Brocke S,
Hausmann S, Steinman L, Wucherpfennig KW.
Semin Immunol.
1998;
10
(1):
57-67
-
Neuropeptides, via specific receptors, regulate T cell adhesion to fibronectin.
Levite M,
Cahalon L, Hershkoviz R, Steinman L, Lider O.
J Immunol.
1998;
160
(2):
993-1000
-
Short peptide-based tolerogens without self-antigenic or pathogenic activity reverse autoimmune disease.
Karin N,
Binah O, Grabie N, Mitchell DJ, Felzen B, Solomon MD, Conlon P, Gaur A, Ling N, Steinman L.
J Immunol.
1998;
160
(10):
5188-94
-
The specificity of the antibody response in multiple sclerosis.
Garren H,
Steinman L, Lock C.
Ann Neurol.
1998;
43
(1):
4-6
-
Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms.
Gaur A,
Boehme SA, Chalmers D, Crowe PD, Pahuja A, Ling N, Brocke S, Steinman L, Conlon PJ.
J Neuroimmunol.
1997;
74
(1-2):
149-58
-
CD4+ T-cell subsets in autoimmunity.
O'Garra A,
Steinman L, Gijbels K.
Curr Opin Immunol.
1997;
9
(6):
872-83
-
Experimental autoimmune encephalomyelitis in IL-4-deficient mice.
Liblau R,
Steinman L, Brocke S.
Int Immunol.
1997;
9
(5):
799-803
-
Exploring the potential of DNA vaccination.
Cohen IR,
Steinman L.
Hosp Pract (1995).
1997;
32
(5):
169-71, 176-8
-
Inhibition of nitric oxide synthase for treatment of experimental autoimmune encephalomyelitis.
Brenner T,
Brocke S, Szafer F, Sobel RA, Parkinson JF, Perez DH, Steinman L.
J Immunol.
1997;
158
(6):
2940-6
-
Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis.
Shaw MK,
Lorens JB, Dhawan A, DalCanto R, Tse HY, Tran AB, Bonpane C, Eswaran SL, Brocke S, Sarvetnick N, Steinman L, Nolan GP, Fathman CG.
J Exp Med.
1997;
185
(9):
1711-4
-
More mayhem from molecular mimics.
Steinman L,
Oldstone MB.
Nat Med.
1997;
3
(12):
1321-2
-
Multiple sclerosis: a polygenic disease involving epistatic interactions, germline rearrangements and environmental effects.
Karpuj MV,
Steinman L, Oksenberg JR.
Neurogenetics.
1997;
1
(1):
21-8
-
Myoblast implantation in Duchenne muscular dystrophy: the San Francisco study.
Miller RG,
Sharma KR, Pavlath GK, Gussoni E, Mynhier M, Lanctot AM, Greco CM, Steinman L, Blau HM.
Muscle Nerve.
1997;
20
(4):
469-78
-
Perivascular T cells express the pro-inflammatory chemokine RANTES mRNA in multiple sclerosis lesions.
Hvas J,
McLean C, Justesen J, Kannourakis G, Steinman L, Oksenberg JR, Bernard CC.
Scand J Immunol.
1997;
46
(2):
195-203
-
Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes.
Wucherpfennig KW,
Catz I, Hausmann S, Strominger JL, Steinman L, Warren KG.
J Clin Invest.
1997;
100
(5):
1114-22
-
Some misconceptions about understanding autoimmunity through experiments with knockouts.
Steinman L,
J Exp Med.
1997;
185
(12):
2039-41
-
Stress and autoimmunity: the neuropeptides corticotropin-releasing factor and urocortin suppress encephalomyelitis via effects on both the hypothalamic-pituitary-adrenal axis and the immune system.
Poliak S,
Mor F, Conlon P, Wong T, Ling N, Rivier J, Vale W, Steinman L.
J Immunol.
1997;
158
(12):
5751-6
-
Viral damage and the breakdown of self-tolerance.
Steinman L,
Conlon P.
Nat Med.
1997;
3
(10):
1085-7
-
A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: a tale of smart bombs and the infantry.
Steinman L,
Proc Natl Acad Sci U S A.
1996;
93
(6):
2253-6
-
CD45 isoforms on human CD4+ T-cell subsets.
Shanafelt MC,
Yssel H, Soderberg C, Steinman L, Adelman DC, Peltz G, Lahesmaa R.
J Allergy Clin Immunol.
1996;
98
(2):
433-40
-
Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87-99).
Vergelli M,
Hemmer B, Utz U, Vogt A, Kalbus M, Tranquill L, Conlon P, Ling N, Steinman L, McFarland HF, Martin R.
Eur J Immunol.
1996;
26
(11):
2624-34
-
IL-2 and TNF receptors as targets of regulatory T-T interactions: isolation and characterization of cytokine receptor-reactive T cell lines in the Lewis rat.
Mor F,
Reizis B, Cohen IR, Steinman L.
J Immunol.
1996;
157
(11):
4855-61
-
Isolation and Characterization of Autoreactive T Cells in Experimental Autoimmune Encephalomyelitis of the Mouse
Brocke S,
Quigley L, McFarland HF, Steinman L.
Methods.
1996;
9
(3):
458-62
-
Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).
Ferber IA,
Brocke S, Taylor-Edwards C, Ridgway W, Dinisco C, Steinman L, Dalton D, Fathman CG.
J Immunol.
1996;
156
(1):
5-7
-
Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system.
Steinman L,
Cell.
1996;
85
(3):
299-302
-
Multiple sclerosis: from a myelin point of view.
Boccaccio GL,
Steinman L.
J Neurosci Res.
1996;
45
(6):
647-54
-
Regulation of disease susceptibility: decreased prevalence of IgE-mediated allergic disease in patients with multiple sclerosis.
Oro AS,
Guarino TJ, Driver R, Steinman L, Umetsu DT.
J Allergy Clin Immunol.
1996;
97
(6):
1402-8
-
Superantigens in demyelinating disease.
Brocke S,
Piercy C, Steinman L.
Springer Semin Immunopathol.
1996;
18
(1):
51-6
-
Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity.
Waisman A,
Ruiz PJ, Hirschberg DL, Gelman A, Oksenberg JR, Brocke S, Mor F, Cohen IR, Steinman L.
Nat Med.
1996;
2
(8):
899-905
-
TCR usage in human and experimental demyelinating disease.
Hafler DA,
Saadeh MG, Kuchroo VK, Milford E, Steinman L.
Immunol Today.
1996;
17
(4):
152-9
-
The right stuff: breaking through the xenotransplant barrier.
Steinman L,
Nat Med.
1996;
2
(11):
1185-6
-
Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein.
Brocke S,
Gijbels K, Allegretta M, Ferber I, Piercy C, Blankenstein T, Martin R, Utz U, Karin N, Mitchell D, Veromaa T, Waisman A, Gaur A, Conlon P, Ling N, Fairchild PJ, Wraith DC, O'Garra A, Fathman CG, Steinman L.
Nature.
1996;
379
(6563):
343-6
-
Coccidioidal antigen reactive CD4+ T-lymphocytes in the cerebrospinal fluid in coccidioides immitis meningitis.
Vollmer TL,
Gaiser C, Dell'Oca RL, Porteus M, Steinman L, Stevens DA.
J Med Vet Mycol.
1995 Jan-Feb;
33
(1):
43-8
-
Administration of neutralizing antibodies to interleukin-6 (IL-6) reduces experimental autoimmune encephalomyelitis and is associated with elevated levels of IL-6 bioactivity in central nervous system and circulation.
Gijbels K,
Brocke S, Abrams JS, Steinman L.
Mol Med.
1995;
1
(7):
795-805
-
Characterization of acute bone marrow graft rejection in T cell-depleted, partially mismatched related donor bone marrow transplantation.
Lamb LS,
Szafer F, Henslee-Downey PJ, Walker M, King S, Godder K, Pati AR, Best R, Steinman L, Geier SS.
Exp Hematol.
1995;
23
(14):
1595-600
-
Designing rational therapies for multiple sclerosis.
Steinman L,
Conlon P.
Biotechnology (N Y).
1995;
13
(2):
118-20
-
Escape from "horror autotoxicus": pathogenesis and treatment of autoimmune disease.
Steinman L,
Cell.
1995;
80
(1):
7-10
-
Fine specificity of the antibody response to myelin basic protein in the central nervous system in multiple sclerosis: the minimal B-cell epitope and a model of its features.
Warren KG,
Catz I, Steinman L.
Proc Natl Acad Sci U S A.
1995;
92
(24):
11061-5
-
Major T-cell responses in multiple sclerosis.
Steinman L,
Waisman A, Altmann D.
Mol Med Today.
1995;
1
(2):
79-83
-
Multiple sclerosis. Presenting an odd autoantigen.
Steinman L,
Nature.
1995;
375
(6534):
739-40
-
Pathogen antigen- and superantigen-reactive synovial fluid T cells in reactive arthritis.
Lahesmaa R,
Soderberg C, Bliska J, Allsup A, Luukkainen R, Steinman L, Uchiyama T, Peltz G.
J Infect Dis.
1995;
172
(5):
1290-7
-
Reinduction of experimental autoimmune encephalomyelitis in mice.
Lindsey JW,
Pappolla M, Steinman L.
Cell Immunol.
1995;
162
(2):
235-40
-
T-cell receptor repertoire V beta in alopecia areata.
Szafer F,
Price VH, Oksenberg JR, Steinman L.
J Invest Dermatol.
1995;
104
(5 Suppl):
22S-24S
-
Unique T-cell receptor junctional sequences found in multiple sclerosis and T-cells mediating experimental allergic encephalomyelitis.
Allegretta M,
Steinman L.
Ann N Y Acad Sci.
1995:
756
265-82
-
A predominant role of integrin alpha 4 in the spontaneous development of autoimmune diabetes in nonobese diabetic mice.
Yang XD,
Michie SA, Tisch R, Karin N, Steinman L, McDevitt HO.
Proc Natl Acad Sci U S A.
1994;
91
(26):
12604-8
-
Cell adhesion molecules: a selective therapeutic target for alleviation of IDDM.
Yang XD,
Michie SA, Tisch R, Karin N, Steinman L, McDevitt HO.
J Autoimmun.
1994;
7
(6):
859-64
-
Homologies between T cell receptor junctional sequences unique to multiple sclerosis and T cells mediating experimental allergic encephalomyelitis.
Allegretta M,
Albertini RJ, Howell MD, Smith LR, Martin R, McFarland HF, Sriram S, Brostoff S, Steinman L.
J Clin Invest.
1994;
94
(1):
105-9
-
Immunopathogenesis of human inflammatory arthritis: lessons from Lyme and reactive arthritis.
Lahesmaa R,
Shanafelt MC, Steinman L, Peltz G.
J Infect Dis.
1994;
170
(4):
978-85
-
Infection and multiple sclerosis: a possible role for superantigens?
Brocke S,
Veromaa T, Weissman IL, Gijbels K, Steinman L.
Trends Microbiol.
1994;
2
(7):
250-4
-
Minimum structural requirements for peptide presentation by major histocompatibility complex class II molecules: implications in induction of autoimmunity.
Gautam AM,
Lock CB, Smilek DE, Pearson CI, Steinman L, McDevitt HO.
Proc Natl Acad Sci U S A.
1994;
91
(2):
767-71
-
Myelin basic protein peptide specificity and T-cell receptor gene usage of HPRT mutant T-cell clones in patients with multiple sclerosis.
Lodge PA,
Allegretta M, Steinman L, Sriram S.
Ann Neurol.
1994;
36
(5):
734-40
-
New allelic polymorphisms in TAP genes.
Szafer F,
Oksenberg JR, Steinman L.
Immunogenetics.
1994;
39
(5):
374
-
Repeated treatment with chimeric anti-CD4 antibody in multiple sclerosis.
Lindsey JW,
Hodgkinson S, Mehta R, Mitchell D, Enzmann D, Steinman L.
Ann Neurol.
1994;
36
(2):
183-9
-
Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production.
Karin N,
Mitchell DJ, Brocke S, Ling N, Steinman L.
J Exp Med.
1994;
180
(6):
2227-37
-
Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.
Gijbels K,
Galardy RE, Steinman L.
J Clin Invest.
1994;
94
(6):
2177-82
-
Specific T cell receptor gene rearrangements at the site of muscle degeneration in Duchenne muscular dystrophy.
Gussoni E,
Pavlath GK, Miller RG, Panzara MA, Powell M, Blau HM, Steinman L.
J Immunol.
1994;
153
(10):
4798-805
-
Specific motifs in T cell receptor V beta D beta J beta gene sequences in multiple sclerosis lesions in brain.
Steinman L,
Behring Inst Mitt.
1994;
(94):
148-57
-
The epigenetics of multiple sclerosis: clues to etiology and a rationale for immune therapy.
Steinman L,
Miller A, Bernard CC, Oksenberg JR.
Annu Rev Neurosci.
1994:
17
247-65
-
Competitive PCR quantification of CD4, CD8, ICAM-1, VCAM-1, and MHC class II mRNA in the central nervous system during development and resolution of experimental allergic encephalomyelitis.
Lindsey JW,
Steinman L.
J Neuroimmunol.
1993 Nov-Dec;
48
(2):
227-34
-
Autoimmune disease.
Steinman L,
Sci Am.
1993;
269
(3):
106-14
-
Connections between the immune system and the nervous system.
Steinman L,
Proc Natl Acad Sci U S A.
1993;
90
(17):
7912-4
-
Diverse T cell receptor V beta gene usage in the central nervous system in experimental allergic encephalomyelitis.
Bell RB,
Lindsey JW, Sobel RA, Hodgkinson S, Steinman L.
J Immunol.
1993;
150
(9):
4085-92
-
From treatment of experimental allergic encephalomyelitis to clinical trials in multiple sclerosis.
Steinman L,
Lindsey JW, Alters S, Hodgkinson S.
Immunol Ser.
1993:
59
253-60
-
Genetic factors in multiple sclerosis.
Oksenberg JR,
Begovich AB, Erlich HA, Steinman L.
JAMA.
1993;
270
(19):
2362-9
-
Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen.
Brocke S,
Gaur A, Piercy C, Gautam A, Gijbels K, Fathman CG, Steinman L.
Nature.
1993;
365
(6447):
642-4
-
Inhibition of insulitis and prevention of diabetes in nonobese diabetic mice by blocking L-selectin and very late antigen 4 adhesion receptors.
Yang XD,
Karin N, Tisch R, Steinman L, McDevitt HO.
Proc Natl Acad Sci U S A.
1993;
90
(22):
10494-8
-
Multiple sclerosis: from immunogenetics to immunotherapy.
Oksenberg JR,
Panzara MA, Steinman L.
J Neurol Sci.
1993:
115 Suppl
S29-37
-
Preferential usage of T cell antigen receptor V region gene segment V beta 5.1 by Borrelia burgdorferi antigen-reactive T cell clones isolated from a patient with Lyme disease.
Lahesmaa R,
Shanafelt MC, Allsup A, Soderberg C, Anzola J, Freitas V, Turck C, Steinman L, Peltz G.
J Immunol.
1993;
150
(9):
4125-35
-
SEB induced anergy: modulation of immune response to T cell determinants of myoglobin and myelin basic protein.
Gaur A,
Fathman CG, Steinman L, Brocke S.
J Immunol.
1993;
150
(7):
3062-9
-
Selection for T cell receptor Vbeta-Dbeta-Jbeta gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis
Steinman L.,
Oksenberg JR, Panzara MA, Begovich AB, Mitchell D, Erlich HA, Murray RS, Shimonkevitz R, Sherritt M, Rothbard J, Bernard CCA,.
Nature.
1993
-
Selection for T-cell receptor V beta-D beta-J beta gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis.
Oksenberg JR,
Panzara MA, Begovich AB, Mitchell D, Erlich HA, Murray RS, Shimonkevitz R, Sherritt M, Rothbard J, Bernard CC.
Nature.
1993;
362
(6415):
68-70
-
Selective and nonselective stages in homing of T lymphocytes to the central nervous system during experimental allergic encephalomyelitis.
Karin N,
Szafer F, Mitchell D, Gold DP, Steinman L.
J Immunol.
1993;
150
(9):
4116-24
-
Therapeutic peptides that block interaction of T cells with MHC in experimental allergic encephalomyelitis.
Steinman L,
Ann N Y Acad Sci.
1993:
685
521-4
-
A polyalanine peptide with only five native myelin basic protein residues induces autoimmune encephalomyelitis.
Gautam AM,
Pearson CI, Smilek DE, Steinman L, McDevitt HO.
J Exp Med.
1992;
176
(2):
605-9
-
Analysis of the T cell repertoire using the PCR and specific oligonucleotide primers.
Panzara MA,
Gussoni E, Steinman L, Oksenberg JR.
Biotechniques.
1992;
12
(5):
728-35
-
Association of susceptibility to multiple sclerosis with TCR genes.
Steinman L,
Oksenberg JR, Bernard CC.
Immunol Today.
1992;
13
(2):
49-51
-
EAE: a model for immune intervention with synthetic peptides.
Smilek DE,
Gautam AM, Pearson C, Steinman L, McDevitt HO.
Int Rev Immunol.
1992;
9
(3):
223-30
-
Expression of granulocyte colony stimulating factor and granulocyte-macrophage colony stimulating factor genes in human astrocytoma cell lines and in glioma specimens.
Nitta T,
Sato K, Allegretta M, Brocke S, Lim M, Mitchell DJ, Steinman L.
Brain Res.
1992;
571
(1):
19-25
-
Inhibition of experimental autoimmune encephalomyelitis by a nonimmunogenic non-self peptide that binds to I-Au.
Gautam AM,
Pearson CI, Sinha AA, Smilek DE, Steinman L, McDevitt HO.
J Immunol.
1992;
148
(10):
3049-54
-
Multiple sclerosis and its animal models: the role of the major histocompatibility complex and the T cell receptor repertoire.
Steinman L,
Springer Semin Immunopathol.
1992;
14
(1):
79-93
-
Neoplastic and reactive human astrocytes express interleukin-8 gene.
Nitta T,
Allegretta M, Okumura K, Sato K, Steinman L.
Neurosurg Rev.
1992;
15
(3):
203-7
-
Normal dystrophin transcripts detected in Duchenne muscular dystrophy patients after myoblast transplantation.
Gussoni E,
Pavlath GK, Lanctot AM, Sharma KR, Miller RG, Steinman L, Blau HM.
Nature.
1992;
356
(6368):
435-8
-
Prevention of experimental autoimmune encephalomyelitis by antibodies against a4b1 integrin
Steinman L,,
Yednock T, Cannon C, Fritz L, Sanchez-Madrid F, and Karin N.
Nature.
1992
-
Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.
Yednock TA,
Cannon C, Fritz LC, Sanchez-Madrid F, Steinman L, Karin N.
Nature.
1992;
356
(6364):
63-6
-
Recurrent transverse myelitis, myasthenia gravis, and autoantibodies.
Lindsey JW,
Albers GW, Steinman L.
Ann Neurol.
1992;
32
(3):
407-9
-
The polymerase chain reaction for detection of T-cell antigen receptor expression.
Panzara MA,
Oksenberg JR, Steinman L.
Curr Opin Immunol.
1992;
4
(2):
205-10
-
Yersinia enterocolitica activates a T helper type 1-like T cell subset in reactive arthritis.
Lahesmaa R,
Yssel H, Batsford S, Luukkainen R, Möttönen T, Steinman L, Peltz G.
J Immunol.
1992;
148
(10):
3079-85
-
[An analysis of lymphokine gene expression within astrocytoma].
Nitta T,
Steinman L, Sato K.
No Shinkei Geka.
1992;
20
(7):
763-8
-
[T-cell receptor repertoire in tumor infiltrating lymphocytes within malignant brain tumors].
Nitta T,
Ikeda M, Cogen P, Steinman L, Sato K.
No Shinkei Geka.
1992;
20
(5):
559-66
-
A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis.
Smilek DE,
Wraith DC, Hodgkinson S, Dwivedy S, Steinman L, McDevitt HO.
Proc Natl Acad Sci U S A.
1991;
88
(21):
9633-7
-
An analysis of T-cell-receptor variable-region genes in tumor-infiltrating lymphocytes within malignant tumors.
Nitta T,
Sato K, Okumura K, Steinman L.
Int J Cancer.
1991;
49
(4):
545-50
-
Modulation of MHC class II antigen expression in human myoblasts after treatment with IFN-gamma.
Mantegazza R,
Hughes SM, Mitchell D, Travis M, Blau HM, Steinman L.
Neurology.
1991;
41
(7):
1128-32
-
New approaches to the therapy of demyelinating disease.
Oksenberg JR,
Steinman L.
Curr Opin Neurobiol.
1991;
1
(3):
436-40
-
Observations on the effect of chimeric anti-CD4 monoclonal antibody in patients with mycosis fungoides.
Knox SJ,
Levy R, Hodgkinson S, Bell R, Brown S, Wood GS, Hoppe R, Abel EA, Steinman L, Berger RG.
Blood.
1991;
77
(1):
20-30
-
Oligonucleotide dot-blot analysis of HLA-DQ beta alleles associated with multiple sclerosis.
Sinha AA,
Bell RB, Steinman L, McDevitt HO.
J Neuroimmunol.
1991;
32
(1):
61-5
-
Prospects for immunotherapy directed to the T cell receptor in human autoimmune disease.
Steinman L,
Ann N Y Acad Sci.
1991:
636
147-53
-
T-cell receptor V beta gene expression differs in tumor-infiltrating lymphocytes within primary and metastatic melanoma.
Nitta T,
Bell R, Okumura K, Sato K, Steinman L.
Cancer Res.
1991;
51
(20):
5565-9
-
The development of rational strategies for selective immunotherapy against autoimmune demyelinating disease.
Steinman L,
Adv Immunol.
1991:
49
357-79
-
Trimolecular interactions in experimental autoimmune demyelinating disease and prospects for immunotherapy.
Bell RB,
Steinman L.
Semin Immunol.
1991;
3
(4):
237-45
-
[Expression of cytokine genes within astrocytoma cell lines and brain specimens].
Nitta T,
Steinman L, Sato K.
No To Shinkei.
1991;
43
(12):
1145-50
-
Development of antigen-specific therapies for autoimmune disease.
Steinman L,
Mol Biol Med.
1990;
7
(4):
333-9
-
Genetic influences on neuroimmunologic disease.
Steinman L,
Res Publ Assoc Res Nerv Ment Dis.
1990:
68
11-4
-
HTLV-I sequences are not detected in peripheral blood genomic DNA or in brain cDNA of multiple sclerosis patients.
Oksenberg JR,
Mantegazza R, Sakai K, Bernard CC, Steinman L.
Ann Neurol.
1990;
28
(4):
574-7
-
Immunogenetic mechanisms in myasthenia gravis.
Steinman L,
Prog Brain Res.
1990:
84
117-24
-
Increased incidence of certain TCR and HLA genes associated with myasthenia gravis in Italians.
Mantegazza R,
Oksenberg JR, Baggi F, Antozzi C, Illeni MT, Pellegris G, Cornelio F, Steinman L.
J Autoimmun.
1990;
3
(4):
431-40
-
Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration.
Sakai K,
Mitchell DJ, Tsukamoto T, Steinman L.
Ann Neurol.
1990;
28
(5):
692-8
-
Limited heterogeneity of rearranged T-cell receptor V alpha transcripts in brains of multiple sclerosis patients.
Oksenberg JR,
Stuart S, Begovich AB, Bell RB, Erlich HA, Steinman L, Bernard CC.
Nature.
1990;
345
(6273):
344-6
-
Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity.
Powell MB,
Mitchell D, Lederman J, Buckmeier J, Zamvil SS, Graham M, Ruddle NH, Steinman L.
Int Immunol.
1990;
2
(6):
539-44
-
Mechanisms of anti-CD4-mediated depletion and immunotherapy. A study using a set of chimeric anti-CD4 antibodies.
Alters SE,
Sakai K, Steinman L, Oi VT.
J Immunol.
1990;
144
(12):
4587-92
-
Predominant expression of T cell receptor V alpha 7 in tumor-infiltrating lymphocytes of uveal melanoma.
Nitta T,
Oksenberg JR, Rao NA, Steinman L.
Science.
1990;
249
(4969):
672-4
-
Prospects for specific immunotherapy in myasthenia gravis.
Steinman L,
Mantegazza R.
FASEB J.
1990;
4
(10):
2726-31
-
The T lymphocyte in experimental allergic encephalomyelitis.
Zamvil SS,
Steinman L.
Annu Rev Immunol.
1990:
8
579-621
-
The use of monoclonal antibodies for treatment of autoimmune disease.
Steinman L,
J Clin Immunol.
1990;
10
(6 Suppl):
30S-38S; discussion 38S-39S
-
The role of the MHC and T-cell receptor in susceptibility to multiple sclerosis.
Oksenberg JR,
Steinman L.
Curr Opin Immunol.
1989-1990 Apr;
2
(4):
619-21
-
Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy.
Wraith DC,
Smilek DE, Mitchell DJ, Steinman L, McDevitt HO.
Cell.
1989;
59
(2):
247-55
-
Comparison of rat and rat-mouse chimeric anti-murine CD4 antibodies in vitro. Chimeric antibodies lyse low-density CD4+ cells.
Alters SE,
Steinman L, Oi VT.
J Immunol.
1989;
142
(6):
2018-23
-
Cyclic adenosine 3',5'-monophosphate metabolism in activated T-cell clones.
Oksenberg D,
Oksenberg JR, Sakai K, Peroutka SJ, Steinman L.
Immunology.
1989;
67
(4):
484-8
-
Evolution, function, and utilization of major histocompatibility complex polymorphism in autoimmune disease.
McDevitt HO,
Wraith DC, Smilek DE, Lundberg AS, Steinman L.
Cold Spring Harb Symp Quant Biol.
1989:
54 Pt 2
853-7
-
Multiple T and B cell epitopes in the S1 subunit ("A"-monomer) of the pertussis toxin molecule.
Oksenberg JR,
Ko C, Judd AK, Lim M, Kent A, Schoolnik GK, Steinman L.
J Immunol.
1989;
143
(12):
4227-31
-
Polymorphic residues on the I-A beta chain modulate the stimulation of T cell clones specific for the N-terminal peptide of the autoantigen myelin basic protein.
Davis CB,
Mitchell DJ, Wraith DC, Todd JA, Zamvil SS, McDevitt HO, Steinman L, Jones PP.
J Immunol.
1989;
143
(7):
2083-93
-
Prevention of experimental encephalomyelitis with peptides that block interaction of T cells with major histocompatibility complex proteins.
Sakai K,
Zamvil SS, Mitchell DJ, Hodgkinson S, Rothbard JB, Steinman L.
Proc Natl Acad Sci U S A.
1989;
86
(23):
9470-4
-
T cell receptors in autoimmune disease as targets for immune intervention.
Acha-Orbea H,
Steinman L, McDevitt HO.
Genome.
1989;
31
(2):
656-61
-
T cell receptors in murine autoimmune diseases.
Acha-Orbea H,
Steinman L, McDevitt HO.
Annu Rev Immunol.
1989:
7
371-405
-
T cell recognition as the target for immune intervention in autoimmune disease.
Wraith DC,
McDevitt HO, Steinman L, Acha-Orbea H.
Cell.
1989;
57
(5):
709-15
-
T-cell receptor V alpha and C alpha alleles associated with multiple and myasthenia gravis.
Oksenberg JR,
Sherritt M, Begovich AB, Erlich HA, Bernard CC, Cavalli-Sforza LL, Steinman L.
Proc Natl Acad Sci U S A.
1989;
86
(3):
988-92
-
A molecular basis for MHC class II--associated autoimmunity.
Todd JA,
Acha-Orbea H, Bell JI, Chao N, Fronek Z, Jacob CO, McDermott M, Sinha AA, Timmerman L, Steinman L.
Science.
1988;
240
(4855):
1003-9
-
A newly characterized HLA DQ beta allele associated with pemphigus vulgaris.
Sinha AA,
Brautbar C, Szafer F, Friedmann A, Tzfoni E, Todd JA, Steinman L, McDevitt HO.
Science.
1988;
239
(4843):
1026-9
-
ADP-ribosyltransferase activity of pertussis toxin and immunomodulation by Bordetella pertussis.
Black WJ,
Munoz JJ, Peacock MG, Schad PA, Cowell JL, Burchall JJ, Lim M, Kent A, Steinman L, Falkow S.
Science.
1988;
240
(4852):
656-9
-
Characterization of a major encephalitogenic T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic protein.
Sakai K,
Zamvil SS, Mitchell DJ, Lim M, Rothbard JB, Steinman L.
J Neuroimmunol.
1988;
19
(1-2):
21-32
-
Immunologic basis for functional recovery in neurologic diseases.
Steinman L,
Adv Neurol.
1988:
47
255-64
-
Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein.
Sakai K,
Sinha AA, Mitchell DJ, Zamvil SS, Rothbard JB, McDevitt HO, Steinman L.
Proc Natl Acad Sci U S A.
1988;
85
(22):
8608-12
-
Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention.
Acha-Orbea H,
Mitchell DJ, Timmermann L, Wraith DC, Tausch GS, Waldor MK, Zamvil SS, McDevitt HO, Steinman L.
Cell.
1988;
54
(2):
263-73
-
MHC-restricted recognition of immunogenic T cell epitopes of pertussis toxin reveals determinants in man distinct from the ADP-ribosylase active site.
Oksenberg JR,
Judd AK, Ko C, Lim M, Fernandez R, Schoolnik GK, Steinman L.
J Exp Med.
1988;
168
(5):
1855-64
-
Multiple discrete encephalitogenic epitopes of the autoantigen myelin basic protein include a determinant for I-E class II-restricted T cells.
Zamvil SS,
Mitchell DJ, Powell MB, Sakai K, Rothbard JB, Steinman L.
J Exp Med.
1988;
168
(3):
1181-6
-
Polymorphic markers of human T-cell receptor alpha and beta genes. Family studies and comparison of frequencies in healthy individuals and patients with multiple sclerosis and myasthenia gravis.
Oksenberg JR,
Gaiser CN, Cavalli-Sforza LL, Steinman L.
Hum Immunol.
1988;
22
(2):
111-21
-
Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis.
Zamvil SS,
Mitchell DJ, Lee NE, Moore AC, Waldor MK, Sakai K, Rothbard JB, McDevitt HO, Steinman L, Acha-Orbea H.
J Exp Med.
1988;
167
(5):
1586-96
-
Molecular approaches toward a therapy for multiple sclerosis.
Steinman L,
Riv Neurol.
1987 May-Jun;
57
(3):
173-4
-
HLA-DQ restriction fragment length polymorphisms in myasthenia gravis.
Bell JI,
Steinman L, Toyka K, McDevitt HO.
Ann N Y Acad Sci.
1987:
505
382-7
-
Importance of immunoglobulin isotype in therapy of experimental autoimmune encephalomyelitis with monoclonal anti-CD4 antibody.
Waldor MK,
Mitchell D, Kipps TJ, Herzenberg LA, Steinman L.
J Immunol.
1987;
139
(11):
3660-4
-
Monoclonal anti-Ia antibody therapy in animal models of autoimmune disease.
McDevitt HO,
Perry R, Steinman LA.
Ciba Found Symp.
1987:
129
184-93
-
Treatment of experimental autoimmune myasthenia gravis with monoclonal antibodies to immune response gene products.
Waldor MK,
O'Hearn M, Sriram S, Steinman L.
Ann N Y Acad Sci.
1987:
505
655-68
Navigation for This Section: Pediatrics
Find a Researcher
Help