Scott Boyd, MD PhD

Clinical Focus

• Hematopathology

Honors and Awards

• New Scholar Award in Aging, Ellison Medical Foundation (2011)
• Walter V. and Idun Berry Fellowship, Stanford University (2008)
• Harry B. Neustein Award, Society of Pediatric Pathology (2008)
• Young Investigator Award, Society of Pediatric Pathology (2007)
• Rhodes Scholarship, University of Oxford (1992-4)

Professional Education

Postdoctoral Advisees

Ramona Hoh,  Krishna Roskin

Industry Relationships

Stanford is committed to ethical and transparent interactions with our industrial and other commercial partners. It is our policy to disclose payments (exclusive of travel support) from, and/or equity in, companies or other commercial entities to Stanford faculty of $5,000 or more in total value, as well as any equity in a privately held company, when the faculty member also has institutional responsibilities related to his or her interactions with the company. View Full Information

Current Research Interests

The lymphocytes of the human immune system share some biological properties with human cancers: in each case, there are subpopulations of cells whose genomes are rearranged and mutated compared to other cells in the body. Our goal is to understand the genotype-phenotype relationships in lymphoid cells that determine the behavior of human diseases. We apply new analytical methods, particularly high-throughput DNA sequencing, in parallel with functional assays to tackle this broad challenge. Our initial focus has been on defining B and T cell populations by deep sequencing of V(D)J rearrangements in clinical samples from healthy individuals as well as patients with immune-mediated diseases or lymphoid malignancies.

Clinical Trials

• Integrated Whole-Genome Analysis of Hematologic Disorders Recruiting
• Understanding Allergies Recruiting

Publications

• Measurement and Clinical Monitoring of Human Lymphocyte Clonality by Massively Parallel V-D-J Pyrosequencing Boyd SD, Marshall EL, Merker JD, Maniar JM, Zhang LN, Sahaf B, Jones CD, Simen BB, Hanczaruk B, Nguyen KD, Nadeau KC, Egholm M, Miklos DB, Zehnder JL, Fire AZ. Science Translational Medicine. 2009; 1 (12)
• The Inference of Phased Haplotypes for the Immunoglobulin H Chain V Region Gene Loci by Analysis of VDJ Gene Rearrangements. Kidd MJ, Chen Z, Wang Y, Jackson KJ, Zhang L, Boyd SD, Fire AZ, Tanaka MM, Gaëta BA, Collins AM. J Immunol. 2012; 188 (3): 1333-40
• Determinants of nucleosome organization in primary human cells. Valouev A, Johnson SM, Boyd SD, Smith CL, Fire AZ, Sidow A. Nature. 2011; 474 (7352): 516-20
• High-throughput VDJ sequencing for quantification of minimal residual disease in chronic lymphocytic leukemia and immune reconstitution assessment. Logan AC, Gao H, Wang C, Sahaf B, Jones CD, Marshall EL, Buño I, Armstrong R, Fire AZ, Weinberg KI, Mindrinos M, Zehnder JL, Boyd SD, Xiao W, Davis RW, Miklos DB. Proc Natl Acad Sci U S A. 2011; 108 (52): 21194-9
• Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated. Liao HX, Chen X, Munshaw S, Zhang R, Marshall DJ, Vandergrift N, Whitesides JF, Lu X, Yu JS, Hwang KK, Gao F, Markowitz M, Heath SL, Bar KJ, Goepfert PA, Montefiori DC, Shaw GC, Alam SM, Margolis DM, Denny TN, Boyd SD, Marshal E, Egholm M, Simen BB, Hanczaruk B, Fire AZ, Voss G, Kelsoe G, Tomaras GD, Moody MA, Kepler TB, Haynes BF. J Exp Med. 2011; 208 (11): 2237-49