Robert W. Shafer

Publication Details

• Evolution of resistance to drugs in HIV-1-infected patients failing antiretroviral therapy.

  Kantor R, Shafer RW, Follansbee S, Taylor J, Shilane D, Hurley L, Nguyen DP, Katzenstein D, Fessel WJ. AIDS. 2004; 18 (11): 1503-11

  The optimal time for changing failing antiretroviral therapy (ART) is not known. It involves balancing the risk of exhausting future treatment options against the risk of developing increased drug resistance. The frequency with which new drug-resistance mutations (DRM) developed and their potential consequences in patients continuing unchanged treatment despite persistent viremia were assessed.

  PubMedID: 15238768