Gerald Crabtree

Publication Details

• Monitoring the duration of antigen-receptor occupancy by calcineurin/glycogen-synthase-kinase-3 control of NF-AT nuclear shuttling.

  Neilson J, Stankunas K, Crabtree GR. Curr Opin Immunol. 2001; 13 (3): 346-50

  Recent structural studies have supported a kinetic model of TCR activation, raising the question of how the duration of receptor occupancy is translated into activation of immune response genes. We summarize evidence that the cytoplasmic-to-nuclear shuttling of NF-ATc family members monitors the duration of receptor occupancy.

  PubMedID: 11406367