Atul Butte

Publication Details

• Systematic survey reveals general applicability of "guilt-by-association" within gene coexpression networks.

  Wolfe CJ, Kohane IS, Butte AJ. BMC Bioinformatics. 2005: 6 227

  Biological processes are carried out by coordinated modules of interacting molecules. As clustering methods demonstrate that genes with similar expression display increased likelihood of being associated with a common functional module, networks of coexpressed genes provide one framework for assigning gene function. This has informed the guilt-by-association (GBA) heuristic, widely invoked in functional genomics. Yet although the idea of GBA is accepted, the breadth of GBA applicability is uncertain.

  PubMedID: 16162296