Robert W. Shafer
Publication Details
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Multiple independent origins of a protease inhibitor resistance mutation in salvage therapy patients.
Retrovirology. 2008: 7
Combination anti-viral therapies have reduced treatment failure rates by requiring multiple specific mutations to be selected on the same viral genome to impart high-level drug resistance. To determine if the common protease inhibitor resistance mutation L90M is only selected once or repeatedly on different HIV genetic backbones during the course of failed anti-viral therapies we analyzed a linked region of the viral genome during the evolution of multi-drug resistance.
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