Luis Fajardo

Publication Details

• Angiogenesis is impaired by hypercholesterolemia: role of asymmetric dimethylarginine.

  Jang JJ, Ho HK, Kwan HH, Fajardo LF, Cooke JP. Circulation. 2000; 102 (12): 1414-9

  Many angiogenic factors require endothelium-derived nitric oxide (NO) to exert their effects. Recently, an endogenous competitive antagonist of NO synthase has been characterized: asymmetric dimethylarginine (ADMA). Elevated plasma levels of ADMA reduce NO synthesis in hypercholesterolemia. Accordingly, we hypothesized that hypercholesterolemia impairs angiogenesis by an ADMA-dependent mechanism.

  PubMedID: 10993861