Matthew Bogyo
Publication Details
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Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes.
Chem Biol. 1998; (6): 307-20
The proteasome is a multicatalytic protease complex responsible for most cytosolic protein breakdown. The complex has several distinct proteolytic activities that are defined by the preference of each for the carboxyterminal (P1) amino acid residue. Although mutational studies in yeast have begun to define substrate specificities of individual catalytically active beta subunits, little is known about the principles that govern substrate hydrolysis by the proteasome.
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