Donna M. Bouley

Publication Details

• Induction of angiogenesis by implantation of encapsulated primary myoblasts expressing vascular endothelial growth factor.

  Springer ML, Hortelano G, Bouley DM, Wong J, Kraft PE, Blau HM. J Gene Med. 2000 Jul-Aug; 2 (4): 279-88

  We previously demonstrated that intramuscular implantation of primary myoblasts engineered to express vascular endothelial growth factor (VEGF) constitutively resulted in hemangioma formation and the appearance of VEGF in the circulation. To investigate the potential for using allogeneic myoblasts and the effects of delivery of VEGF-expressing myoblasts to non-muscle sites, we have enclosed them in microcapsules that protect allogeneic cells from rejection, yet allow the secretion of proteins produced by the cells.

  PubMedID: 10953919