Eugene Butcher
Publication Details
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A cell-surface molecule involved in organ-specific homing of lymphocytes.
Nature. 1983 Jul 7-13; (5921): 30-4
Lymphocytes migrate from the bloodstream by recognizing and binding to specialized endothelial cells lining the high endothelial venules (HEV) in lymph nodes and Peyer's patches. We describe here a monoclonal antibody, MEL-14, specific for a lymphocyte surface molecule that appears to mediate recognition of lymph node HEV, and to be required for lymphocyte homing into lymph nodes in vivo.
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