Howard Sussman

Publication Details

• The protein kinase C inhibitor, H-7, induces acute lung injury in guinea pigs.

  Tanigaki T, Suzuki Y, Heimer D, Wang W, Sussman HH, Ross WG, Murphy GA, Ikeda H, Raffin TA. Crit Care Med. 1994; 22 (7): 1167-73

  To determine if the protein kinase C inhibitor, H-7, alone can cause acute lung injury. In cell studies, H-7 inhibited phorbol myristate acetate-induced neutrophil oxygen radical release. Additionally, one animal study demonstrated that H-7 inhibited phorbol myristate acetate-induced lung injury. There have been no studies on the effect of H-7 alone on lung function or on neutrophil release of oxygen radicals.

  PubMedID: 8026208