Richard Sibley

Publication Details

• Expression of insulin-like growth factor-I and transforming growth factor-beta in hypokalemic nephropathy in the rat.

  Tsao T, Fawcett J, Fervenza FC, Hsu FW, Huie P, Sibley RK, Rabkin R. Kidney Int. 2001; 59 (1): 96-105

  Potassium deficiency (KD) in the rat retards body growth but stimulates renal enlargement caused by cellular hypertrophy and hyperplasia, which is most marked in the outer medulla. If hypokalemia persists, interstitial infiltrates appear and eventually fibrosis. Since early in KD insulin-like growth factor-I (IGF-I) levels in the kidney are elevated, suggesting that it may be an early mediator of the exaggerated renal growth, and as transforming growth factor-beta (TGF-beta) promotes cellular hypertrophy and fibrosis, we examined the renal expression of these growth factors in prolonged KD.

  PubMedID: 11135062