Atilio Jesus Duque-Afonso

Publications

• Regulation of the adaptor molecule LAT2, an in vivo target gene of AML1/ETO (RUNX1/RUNX1T1), during myeloid differentiation. Duque-Afonso J, Solari L, Essig A, Berg T, Pahl HL, Lübbert M. Br J Haematol. 2011; 153 (5): 612-22
• The HDAC class I-specific inhibitor entinostat (MS-275) effectively relieves epigenetic silencing of the LAT2 gene mediated by AML1/ETO. Duque-Afonso J, Yalcin A, Berg T, Abdelkarim M, Heidenreich O, Lübbert M. Oncogene. 2011; 30 (27): 3062-72
• The DNA demethylating agent 5-aza-2'-deoxycytidine induces expression of NY-ESO-1 and other cancer/testis antigens in myeloid leukemia cells. Almstedt M, Blagitko-Dorfs N, Duque-Afonso J, Karbach J, Pfeifer D, Jäger E, Lübbert M. Leuk Res. 2010; 34 (7): 899-905
• Histone deacetylase inhibitors induce a very broad, pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter genes. Hauswald S, Duque-Afonso J, Wagner MM, Schertl FM, Lübbert M, Peschel C, Keller U, Licht T. Clin Cancer Res. 2009; 15 (11): 3705-15
• Complementing mutations in core binding factor leukemias: from mouse models to clinical applications. Müller AM, Duque J, Shizuru JA, Lübbert M. Oncogene. 2008; 27 (44): 5759-73
• Two cell lines of t(8;21) acute myeloid leukemia with activating KIT exon 17 mutation: models for the 'second hit' hypothesis. Becker H, Pfeifer D, Afonso JD, Nimer SD, Veelken H, Schwabe M, Lübbert M. Leukemia. 2008; 22 (9): 1792-4
• XXIII International Association for Comparative Research on Leukemia and Related Diseases Symposium: from molecular pathogenesis to targeted therapy in leukemia and solid tumors. Hackanson B, Becker H, Berg T, Binder M, Dierks C, Duque-Afonso J, Lairmore MD, Schäfer HS, Schnitzler M, Zeiser R, Martens U, Mertelsmann R, Lübbert M. Cancer Res. 2008; 68 (14): 5512-8
• Inhibitors of DNA methylation and histone deacetylation independently relieve AML1/ETO-mediated lysozyme repression. Claus R, Fliegauf M, Stock M, Duque JA, Kolanczyk M, Lübbert M. J Leukoc Biol. 2006; 80 (6): 1462-72