Matt Van de Rijn

Clinical Focus

• Pathology and Laboratory Medicine
• Anatomic/Clinical Pathology

Professional Education

Web Site Links

• van de Rijn Lab

Research Interests

Our research focuses on gene microarray analysis of human soft tissue tumors (sarcomas). In addition we work with tissue microarrays to characterize large numbers of novel antisera raised against peptides derived from genes found to be of interest during gene array analysis. These genes are not only identified in sarcomas but, through collaborations with other laboratories, also in a large number of other human neoplasms, including breast, kidney, prostate, lung, and liver tumors.

Clinical Trials

• Identification and Characterization of Novel Proteins in Head and Neck Cancer Recruiting

Publications

• Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Chan KS, Espinosa I, Chao M, Wong D, Ailles L, Diehn M, Gill H, Presti J, Chang HY, van de Rijn M, Shortliffe L, Weissman IL. Proc Natl Acad Sci U S A. 2009; 106 (33): 14016-21
• Gene expression profiling for the investigation of soft tissue sarcoma pathogenesis and the identification of diagnostic, prognostic, and predictive biomarkers. Beck AH, West RB, van de Rijn M. Virchows Arch. 2009
• The macrophage colony-stimulating factor 1 response signature in breast carcinoma. Beck AH, Espinosa I, Edris B, Li R, Montgomery K, Zhu S, Varma S, Marinelli RJ, van de Rijn M, West RB. Clin Cancer Res. 2009; 15 (3): 778-87
• Coordinate expression of colony-stimulating factor-1 and colony-stimulating factor-1-related proteins is associated with poor prognosis in gynecological and nongynecological leiomyosarcoma. Espinosa I, Beck AH, Lee CH, Zhu S, Montgomery KD, Marinelli RJ, Ganjoo KN, Nielsen TO, Gilks CB, West RB, van de Rijn M. Am J Pathol. 2009; 174 (6): 2347-56
• Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling. Beck AH, Lee CH, Witten DM, Gleason BC, Edris B, Espinosa I, Zhu S, Li R, Montgomery KD, Marinelli RJ, Tibshirani R, Hastie T, Jablons DM, Rubin BP, Fletcher CD, West RB, van de Rijn M. Oncogene. 2009