Matthew Bogyo

Honors and Awards

• Investigator in Pathogenesis of Infectious Disease, Burroughs Wellcome (May 2005)
• Terman Fellow, Stanford University (2003)
• Searle Scholar, Searle Scholars Program (2004)

Professional Education

Postdoctoral Advisees

Victoria Albrow , Paul Bowyer , Edgar Deu Sandoval , Jiyoun Lee , Montserrat Morell Fernandez , Margot Paulick , Elizabeth Ponder , Aimee Shen , Martijn Verdoes , Fangfang Yin

Graduate & Fellowship Program Affiliations

• Cancer Biology
• Microbiology and Immunology
• Chemical and Systems Biology

Web Site Links

• Bogyo Lab Main Site

Current Research Interests

Our lab uses chemical, biochemical, and cell biological methods to study protease function in human disease. Projects include:

1) Design and synthesis of novel chemical probes for each of the primary protease families.

2) Understanding the role of proteolysis in the life cycle of the human parasites, Plasmodium falciparum and Toxoplasma gondii.

3) Defining the specific functional roles of proteases during the process of tumorogenesis.

4) In vivo imaging of protease activity

Publications

• Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum. Arastu-Kapur S, Ponder EL, Fonovi? UP, Yeoh S, Yuan F, Fonovi? M, Grainger M, Phillips CI, Powers JC, Bogyo M. Nat Chem Biol. 2008; 4 (3): 203-13
• Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes. Blum G, von Degenfeld G, Merchant MJ, Blau HM, Bogyo M. Nat Chem Biol. 2007; 3 (10): 668-77
• Design, synthesis, and evaluation of in vivo potency and selectivity of epoxysuccinyl-based inhibitors of papain-family cysteine proteases. Sadaghiani AM, Verhelst SH, Gocheva V, Hill K, Majerova E, Stinson S, Joyce JA, Bogyo M. Chem Biol. 2007; 14 (5): 499-511
• A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C. Yuan F, Verhelst SH, Blum G, Coussens LM, Bogyo M. J Am Chem Soc. 2006; 128 (17): 5616-7
• Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes. Berger AB, Witte MD, Denault JB, Sadaghiani AM, Sexton KM, Salvesen GS, Bogyo M. Mol Cell. 2006; 23 (4): 509-21