Campus Image
Orthopaedic Surgery
Christopher Jacobs Info

Christopher Jacobs

Profile: http://med.stanford.edu/profiles/Christopher_Jacobs/
Academic Appointments
Appointment
Organization
Associate Professor (Research)
Mechanical Engineering
Associate Professor (Research) (By courtesy)
Bioengineering
Associate Professor (Research)
Orthopaedic Surgery
Member
Bio-X
Graduate & Fellowship Program Affiliations
Orthopedic Surgery ; Bioengineering ;
 
Honors & Awards
Title
Organization
Date(s)
Young Investigator Award
American Society of Biomechanics
1998
Research Award
European Society of Biomechanics
1998
Administrative Appointments
Title
Organization
Start Year
End Year
President
Society for Physical Regulation in Biology and Medicine
2006
-
Co-Editor
Computer Methods in Biomechanics and Biomedical Engineering
2007
-
Skeletal Biology Structure and Regeneration Study Section Member
NIH
2003
-
Web Site Links
Research/Lab website:   Cell and Molecular Biomechanics Lab
Research Interests

Dr. Jacobs is primarily interested in cellular mechanics and molecular mechanisms of cellular mechanotransduction particularly in bone. His recent work is focused on how fluid flow due to mechanical loading is transduced by bone cells. He also investigates the mechanical influence on and regulation of stress-adaptive orthopaedic structures, tissues, and cells. He is also the director of the Palo Alto DVA Center for Bone and Joint Rehabilitation Research and Development.

Publications
  • Malone A, Batra NN, Shivaram G, Kwon R, You L, Kim CH, Rodriguez J, Jair K, Jacobs CR "The Role of the Actin Cytoskeleton in Oscillatory Fluid Flow Induced Signaling in MC3T3-E1 Osteoblasts." Am J Physiol Cell Physiol 2007; More »
  • Kwon RY, Jacobs CR "Time-dependent deformations in bone cells exposed to fluid flow in vitro: investigating the role of cellular deformation in fluid flow-induced signaling." J Biomech 2007; More »
  • Kim CH, You L, Yellowley CE, Jacobs CR "Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling." Bone 2006; More »
  • Batra NN, Li YJ, Yellowley CE, You L, Malone AM, Kim CH, Jacobs CR "Effects of short-term recovery periods on fluid-induced signaling in osteoblastic cells." J Biomech 2005; 38: 9: 1909-17 More »
  • Li YJ, Batra NN, You L, Meier SC, Coe IA, Yellowley CE, Jacobs CR "Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation." J Orthop Res 2004; 22: 6: 1283-9 More »
61 publications:   view full list