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Aaron HsuehAcademic Appointments
Appointment
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Web Site Links
Research/Lab website:
Hsueh Lab Home Page
Research Interests
We have been investigating the molecular and cellular mechanisms underlying the hormonal regulation of ovarian follicle growth and differentiation. By expressing recombinant FSH, LH and hCG and producing their mutants, we have designed long-acting agonists as well as deglycosylated antagonists of gonadotropins. We have also cloned human LH and FSH receptors and the expression of these proteins allows analysis of gonadotropin bioactivity in vitro. The extracellular ligand-binding domain of these receptors have been generated and found to be functional antagonists. Clinical syndromes of gain-of-function mutations for the LH receptor have been found in patients with familial male precocious puberty whereas loss-of-function mutations have been found to be the basis of Leydig cell hypoplasia. We are using bioinformatic tools and DNA microarray to analyze polypeptide hormones andtheir receptors in terms of ligand-receptor matching and paracrine interactions.
Publications
- Ben-Shlomo I, Rauch R, Avsian-Kretchmer O, Hsueh AJ "Matching Receptome Genes with Their Ligands for Surveying Paracrine/Autocrine Signaling Systems." Mol Endocrinol 2007; More »
- Luo CW, Hsueh AJ "Genomic analyses of the evolution of LGR genes." Chang Gung Med J 2006 Jan-Feb; 29: 1: 2-8 More »
- Mazerbourg S, Hsueh AJ "Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands." Hum Reprod Update 2006; More »
- De A, Park JI, Kawamura K, Chen R, Klein C, Rauch R, Mulders SM, Sollewijn Gelpke MD, Hsueh AJ "Intraovarian TWEAK/Fn14 ligand-receptor system limits ovarian preovulatory follicles from excessive luteinization." Mol Endocrinol 2006; More »
- Sudo S, Kuwabara Y, Park JI, Hsu SY, Hsueh AJ "Heterodimeric Fly GPA2 and GPB5 Activate Fly LGR1 and Stimulation of Human TSH Receptors by Chimeric Fly GPA2 and Human GPB5." Endocrinology 2005; More »
112 publications: view full list
