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Nihar Nayak, Ph.D., D.V.M.
Email:
Profile: http://med.stanford.edu/profiles/Nihar_Nayak/
Alternate Contact: Academic Appointments
Appointment
Organization
Assistant Professor
Member
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Honors & Awards
Title
Organization
Date(s)
Building Interdisciplinary Research Careers in Women's Health (BIRCWH) Award
NIH
2004-2008
Junior Investigator Award
Andrew W. Mellon Foundation
2000-2004
Burroughs Wellcome Fund Travel Fellow
Society for the Study of Reproduction
1999
Travel Grant Award
Endocrine Society
1999
Postdoctoral Fellowship Award
Lalor Foundation
1998-2000
9 honors and awards: view full list
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
Postdoctoral Fellowship
ONPRC, Oregon, USA
Reproductive Sciences
2000
PhD
AIIMS, New Delhi
Reproductive Physiology
1998
MVSc
Orissa Univ of Agril and Tech
Veterinary Physiology
1989
BVSc & AH
Orissa Univ of Agril and Tech
Veterinary Medicine
1986
Research Interests
Research in my laboratory is focused on understanding the mechanisms of endometrial angiogenesis and vascular remodeling during the menstrual cycle and pregnancy. We are particularly interested in understanding the mechanisms of spiral artery growth and remodeling in the primate uterus. These arteries are unique to the primate endometrium. They develop from the radial arteries of the myometrium and course through the endometrium, where they develop their coiled structure and vascularize primarily the upper endometrial zones. Their growth is primarily driven by progesterone in the luteal phase of the menstrual cycle and pregnancy. At the end of a nonfertile cycle, when progesterone levels fall, the spiral arteries severely constrict, leading to ischemia of the upper endometrial zones and menstrual breakdown of endometrium. During pregnancy, the trophoblasts invade the spiral arteries and replace the internal lining of these arteries, thereby regulate the vascular resistance and blood flow to the placenta and fetus. The degree of trophoblast invasion into these arteries appears to be a major determinant of pregnancy outcome. Inadequate invasion, particularly restricted endovascular invasion of spiral arteries, has been implicated in the pathophysiology of preeclampsia, preterm labor, and intrauterine growth restriction (lUGR). We believe that most of the pregnancy-related vascular complications manifested late in gestation, including preeclampsia, have their origins early in pregnancy. Our main goal is to identify the abnormalities in implantation that may lead to various pregnancy-related vascular complications.
Publications
- Fan X, Krieg S, Kuo CJ, Wiegand SJ, Rabinovitch M, Druzin ML, Brenner RM, Giudice LC, Nayak NR "VEGF blockade inhibits angiogenesis and reepithelialization of endometrium." FASEB J 2008; More »
- Kuhnert F, Tam BY, Sennino B, Gray JT, Yuan J, Jocson A, Nayak NR, Mulligan RC, McDonald DM, Kuo CJ "Soluble receptor-mediated selective inhibition of VEGFR and PDGFR{beta} signaling during physiologic and tumor angiogenesis." Proc Natl Acad Sci U S A 2008; More »
- Nayak NR, Slayden OD, Mah K, Chwalisz K, Brenner RM "Antiprogestin-releasing intrauterine devices: a novel approach to endometrial contraception." Contraception 2007; 75: 6 Suppl: S104-11 More »
- Hess AP, Hamilton AE, Talbi S, Dosiou C, Nyegaard M, Nayak N, Genbecev-Krtolica O, Mavrogianis P, Ferrer K, Kruessel J, Fazleabas AT, Fisher SJ, Giudice LC "Decidual stromal cell response to paracrine signals from the trophoblast: amplification of immune and angiogenic modulators." Biol Reprod 2007; 76: 1: 102-17 More »
- Nayak NR, Kuo CJ, Desai TA, Wiegand SJ, Lasley BL, Giudice LC, Brenner RM "Expression, localization and hormonal control of angiopoietin-1 in the rhesus macaque endometrium: potential role in spiral artery growth." Mol Hum Reprod 2006; More »
26 publications: view full list
