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Mylene W. M. Yao, M.D.
Email:
Profile: http://med.stanford.edu/profiles/Mylene_Yao/
Alternate Contact: Academic Appointments
Appointment
Organization
Assistant Professor
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Curriculum Vitae Doc
Honors & Awards
Title
Organization
Date(s)
Organon Research Award
American Society for Reproductive Medicine (ASRM)
2003
Reproductive Scientist Development Program (RSDP) Research Award
American Society for Reproductive Medicine (ASRM)/NICHD
2002
Academic Training Fellowship Award in Ob/Gyn
American College of Obstetrics and Gynecology (ACOG)/Ortho-McNeil Pharmaceutical
2000
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
Fellowship
Harvard Medical School
REI
2001
Chief Resident
McGill University
OB/GYN
1998
Residency
McGill University
OB/GYN
1998
MD
University of Toronto
Medicine
1993
Research Interests
Mylene’s laboratory is interested in early mammalian embryo development. We investigate genes and mechanisms that are critical in the maternal-zygotic and the morula-blastocyst transitions using experimental systems that we have established for the mouse and human embryo. Specifically, we aim to understand how key processes such as nuclear reprogramming, establishment of developmental competence, maintenance of pluripotency, and cell cycle regulation are regulated at the earliest stages.
Our research is relevant to the fields of stem cell, cancer, and assisted reproductive technologies (ART). Errors that occur during early embryo development, can lead to a wide spectrum of clinical conditions such as pregnancy loss, obstetrical complications, congenital defects, and infertility. Further, the fields of embryonic stem cell and reproductive medicine research face similar challenges, as exemplified by the limited rates of human blastocyst development. Finally, unique mechanisms, such as those regulating cleavage divisions, transcription and apoptosis, make the preimplantation embryo a valuable experimental model for stem cell and cancer research.
Our research is relevant to the fields of stem cell, cancer, and assisted reproductive technologies (ART). Errors that occur during early embryo development, can lead to a wide spectrum of clinical conditions such as pregnancy loss, obstetrical complications, congenital defects, and infertility. Further, the fields of embryonic stem cell and reproductive medicine research face similar challenges, as exemplified by the limited rates of human blastocyst development. Finally, unique mechanisms, such as those regulating cleavage divisions, transcription and apoptosis, make the preimplantation embryo a valuable experimental model for stem cell and cancer research.
Publications
- Burney R, Schust DJ, Yao MWM. "Infertility" Berek and Novak's Gynecology 2006; 14th Ed: More »
- Yao MWM, Batchu K. "Oogenesis" Clinical Reproductive Medicine and Surgery 2006; 1st Ed: More »
- Polan ML, Yao M "Uterine stem cell transfer: the chicken teaches the egg." JAMA 2004; 292: 1: 104-5 More »
- Yao M,, Lim H, Schust DJ, Choe SE, Farago A, Ding Y, Michaud S, Church GM, Maas RL "Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the pre-implantation uterus" Molecular Endocrinology 2003; 17: 610-627 More »
- Ma L, Yao M, Maas RL "Genetic conrol of unterine receptivity during implantation" Seminars in Reproductive Endocrinology 1999; 17: 3: 205-216 More »
9 publications: view full list
