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Eric ChiaoAcademic Appointments
Appointment
Organization
Instructor
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Research Interests
In a broad sense, my research has two goals:
1. Utilize hESCs as a model system to study early human developmental biology; and
2. Develop tools needed to advance the field of regenerative medicine.
First, I am currently working on understanding the molecular mechanisms underlying hESC pluripotency and differentiation towards the endoderm lineage. I have developed a system to direct the differentiation of human ES cells into hepatic cells and am examining the genetic programs of the purified hepatic cell types.
Second, I am deriving new human embryonic stem cell lines using novel culture conditions and lines with inherited genetic diseases. I have derived four new lines, two in standard media and two using novel xeno-free, chemically defined conditions. Additionally, I am deriving new disease specific lines using blastocysts that would otherwise be discarded because they had been identified by pre-implantation genetic diagnosis to harbor specific genetic lesions.
1. Utilize hESCs as a model system to study early human developmental biology; and
2. Develop tools needed to advance the field of regenerative medicine.
First, I am currently working on understanding the molecular mechanisms underlying hESC pluripotency and differentiation towards the endoderm lineage. I have developed a system to direct the differentiation of human ES cells into hepatic cells and am examining the genetic programs of the purified hepatic cell types.
Second, I am deriving new human embryonic stem cell lines using novel culture conditions and lines with inherited genetic diseases. I have derived four new lines, two in standard media and two using novel xeno-free, chemically defined conditions. Additionally, I am deriving new disease specific lines using blastocysts that would otherwise be discarded because they had been identified by pre-implantation genetic diagnosis to harbor specific genetic lesions.
Publications
No information available
