Michael Longaker

Publication Details

• Elucidating mechanisms of osteogenesis in human adipose-derived stromal cells via microarray analysis.

  Lee J, Gupta D, Panetta NJ, Levi B, James AW, Wan D, Commons GW, Longaker MT. J Craniofac Surg. 2010; 21 (4): 1136-41

  The osteogenic potential of human adipose-derived stromal cells (hASCs), the ease of cell procurement, and the shortcomings of conventional skeletal reconstruction call for further analysis of the molecular mechanisms governing hASC osteogenic differentiation. We have examined the expression profile of the human transcriptome during osteogenic differentiation of ASCs using microarray. Subsequently, we analyzed those genes related to osteogenesis that have not been previously studied about hASCs. We have preliminarily assessed the role of IGFBP3, TGF-B3, TNC, CTGF, DKK-1, and PDGFRB in hASC osteogenic differentiation.

  PubMedID: 20613589