Michael Longaker

Publication Details

• Calcium-based nanoparticles accelerate skin wound healing.

  Kawai K, Larson BJ, Ishise H, Carre AL, Nishimoto S, Longaker M, Lorenz HP. PLoS One. 2011; 6 (11): e27106

  Nanoparticles (NPs) are small entities that consist of a hydroxyapatite core, which can bind ions, proteins, and other organic molecules from the surrounding environment. These small conglomerations can influence environmental calcium levels and have the potential to modulate calcium homeostasis in vivo. Nanoparticles have been associated with various calcium-mediated disease processes, such as atherosclerosis and kidney stone formation. We hypothesized that nanoparticles could have an effect on other calcium-regulated processes, such as wound healing. In the present study, we synthesized pH-sensitive calcium-based nanoparticles and investigated their ability to enhance cutaneous wound repair.

  PubMedID: 22073267