George Triadafilopoulos

Clinical Focus

• Gastroenterology

Honors and Awards

• Distinguished Service Award, American Society for Gastrointestinal Endoscopy (2009)

Professional Education

Graduate & Fellowship Program Affiliations

• Medicine

Industry Relationships

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Research Interests

My primary research interest concerns factors involved in the pathogenesis of gastro-esophageal reflux disease (GERD) and its complications, such as Barrett's esophagus. Over the past decade I have explored the potential role of COX-2 expression and activity, prostaglandin and leukotriene production and cell proliferation in inducing and amplifying symptoms and disease evolution. Ongoing studies in the area of Barrett's metaplasia involve characterizing unique cell surface or intracellular molecular changes that occur in the early stages of metaplastic transformation and identification of environmental factors that predispose to esophageal metaplasia. In particular, I am interested in the role of acid and bile reflux in modifying cellular alterations and contributing to dysplasia and neoplasia. Furthermore, in clinical studies, I am investigating the role of 24-hour dual pH monitoring in the management of patients with reflux-like dyspepsia, esophagitis, and Barrett’s esophagus, and particularly the role of intensive proton pump inhibitor therapy in chemoprevention against esophageal adenocarcinoma. I have a very active clinical base of patients with Barrett’s esophagus in which advanced diagnostic (narrow band imaging, in vivo confocal microscopy, chromo-endoscopy) as well as therapeutic (endoscopic mucosal resection, radiofrequency ablation) modalities are prospectively explored and validated.

Publications

• Endoscopic evaluation of esophago-gastro-jejunostomy in rat model of Barrett's esophagus. Lu S, Lowe AW, Triadafilopoulos G, Hsiung PL, Hao Y, Crawford JM, Wang TD. Dis Esophagus. 2009; 22 (4): 323-30
• Meckel's Diverticulum with Gastrointestinal Bleeding: Role of Computed Tomography in Diagnosis. Munroe CA, Copland A, Pai R, Friedland S, Triadafilopoulos G. Dig Dis Sci. 2009
• Pragmatic classification of superficial neoplastic colorectal lesions. Lambert R, Kudo SE, Vieth M, Allen JI, Fujii H, Fujii T, Kashida H, Matsuda T, Mori M, Saito H, Shimoda T, Tanaka S, Watanabe H, Sung JJ, Feld AD, Inadomi JM, O'Brien MJ, Lieberman DA, Ransohoff DF, Soetikno RM, Zauber A, Teixeira CR, Rey JF, Jaramillo E, Rubio CA, Van Gossum A, Jung M, Jass JR, Triadafilopoulos G. Gastrointest Endosc. 2009
• What is left of the endoscopic antireflux devices? Jafri SM, Arora G, Triadafilopoulos G. Curr Opin Gastroenterol. 2009; 25 (4): 352-7
• Proton pump inhibitors for gastroduodenal damage related to nonsteroidal anti-inflammatory drugs or aspirin: twelve important questions for clinical practice. Arora G, Singh G, Triadafilopoulos G. Clin Gastroenterol Hepatol. 2009; 7 (7): 725-35