Gary K. Steinberg, MD, PhD

Publication Details

• Mild postischemic hypothermia prolongs the time window for gene therapy by inhibiting cytochrome C release.

  Zhao H, Yenari MA, Sapolsky RM, Steinberg GK. Stroke. 2004; 35 (2): 572-7

  We showed previously that Bcl-2 overexpression with the use of herpes simplex viral (HSV) vectors improved striatal neuron survival when delivered 1.5 hours after stroke but not when delivered 5 hours after stroke onset. Here we determine whether hypothermia prolongs the therapeutic window for gene therapy.

  PubMedID: 14726551